DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HDAC4 and hda17

DIOPT Version :9

Sequence 1:	NP_001259507.1	Gene:	HDAC4 / 32278	FlyBaseID:	FBgn0041210	Length:	1269	Species:	Drosophila melanogaster
Sequence 2:	NP_190035.1	Gene:	hda17 / 823574	AraportID:	AT3G44490	Length:	158	Species:	Arabidopsis thaliana

Alignment Length:	175	Identity:	43/175 - (24%)
Similarity:	67/175 - (38%)	Gaps:	46/175 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   903 AHAMLF-GSNQCQLSRPKLENTLSASFVR------LSCGGLGVDLDTTWNEHHTATAARMAAGCV 960
            |.:||| |..:|            ..||:      |..||.|      :.:.:.|....:..|.:
plant     2 AFSMLFTGHAEC------------VKFVKKFNLPLLVTGGGG------YTKENVARCWTVETGIL 48

  Fly   961 IDLAL--KTAKGDLRNGFA---VVRPPGHHAEANLAMGFCFFNSIAI-AAKLLR--QRMPEVRR- 1016
            :|..|  :.::.|....||   .::.||.|.| ||... .:.:||.: ..:.||  |..|.|:.
plant    49 LDTELPNEISENDYIKYFAPDFSLKIPGGHIE-NLNTK-SYISSIKVQILENLRYIQHAPSVQMQ 111

  Fly  1017 -----ILIVDWDVHHGNGTQQAFYQSPDILYLSIHRHDDGNFFPG 1056
                 ..|.|:|....|...:...:|.|   ..|.|.|:  :|.|
plant   112 EVPPDFYIPDFDEDEQNPDVRVDQRSRD---KQIQRDDE--YFDG 151

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HDAC4	NP_001259507.1	iSH2_PI3K_IA_R	43..>87	CDD:304922
HDAC4	NP_001259507.1	HDAC_classIIa	837..1211	CDD:212544	43/175 (25%)
hda17	NP_190035.1	Arginase_HDAC	<3..116	CDD:302587	31/132 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0123
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810