DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HDAC4 and HDA15

DIOPT Version :9

Sequence 1:	NP_001259507.1	Gene:	HDAC4 / 32278	FlyBaseID:	FBgn0041210	Length:	1269	Species:	Drosophila melanogaster
Sequence 2:	NP_850609.2	Gene:	HDA15 / 821382	AraportID:	AT3G18520	Length:	564	Species:	Arabidopsis thaliana

Alignment Length:	424	Identity:	169/424 - (39%)
Similarity:	238/424 - (56%)	Gaps:	35/424 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   831 GSPPHKVTTGLAYDPLMLKHSCICGDNAQHPEHSGRLQSVWARLNETDLVK-RCDRLRARKATQE 894
            ||.....:|.:.:|..||.||........|||...||:::.|.|....:.. ||..:.||:.|::
plant   142 GSSSATSSTAVGFDERMLLHSEFEVKAQPHPERPDRLRAIAASLATAGVFPGRCLPINAREITKQ 206

  Fly   895 ELQTVHTEAHAMLFGSNQCQLSRPKLENTLSASFVRLSCGGLGVDLDTTWNEHHTATAARMAAGC 959
            |||.|||..|.....:.. ||        |.:.|..          ||..|| ::|.|||:|||.
plant   207 ELQMVHTSEHVDAVDTTS-QL--------LYSYFTS----------DTYANE-YSARAARLAAGL 251

  Fly   960 VIDLALKTAKGDLRNGFAVVRPPGHHAEANLAMGFCFFNSIAIAAKLLRQRMPEVRRILIVDWDV 1024
            ..|||.....|.::||||:||||||||....|||||..|:.|:||  |..:....:::|||||||
plant   252 CADLATDIFTGRVKNGFALVRPPGHHAGVRHAMGFCLHNNAAVAA--LVAQAAGAKKVLIVDWDV 314

  Fly  1025 HHGNGTQQAFYQSPDILYLSIHRHDDGNFFPGTGGPTECGSGAGLGFNVNISWS-GALNPPLGDA 1088
            |||||||:.|.|:..:||:|:|||:.|||:||||...|.||..|.|:.||:.|| |.    :||.
plant   315 HHGNGTQEIFEQNKSVLYISLHRHEGGNFYPGTGAADEVGSNGGEGYCVNVPWSCGG----VGDK 375

  Fly  1089 EYIAAFRTVVMPIARSFNPDIVLVSSGFDAATGHPAPLGGYHVSPACFGFMTRELLQLANGKVVL 1153
            :||.||:.||:|||.:|:||.|::|:|||||.|.  |||...|:||.:..||:.|..|..||:::
plant   376 DYIFAFQHVVLPIASAFSPDFVIISAGFDAARGD--PLGCCDVTPAGYSRMTQMLGDLCGGKMLV 438

  Fly  1154 ALEGGYDLAAICDSAQECVRALLGDPAAPIAKAELERPPCQNAINTLQKTIAIQQTHWPCVRMLE 1218
            .|||||:|.:|..||...::.|||:  .|..:..:...|....:.|:...:.||...||.: .:.
plant   439 ILEGGYNLRSISASATAVIKVLLGE--NPENELPIATTPSVAGLQTVLDVLNIQLEFWPSL-AIS 500

  Fly  1219 HTVGLSALETLKVEH--DESETINAMAGLSMQSM 1250
            ::..||.||...:|:  ::|:.....:|..|..|
plant   501 YSKLLSELEARLIENKSEKSDEKEGCSGSDMVEM 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HDAC4	NP_001259507.1	iSH2_PI3K_IA_R	43..>87	CDD:304922
HDAC4	NP_001259507.1	HDAC_classIIa	837..1211	CDD:212544	156/375 (42%)
HDA15	NP_850609.2	HDAC_classII	171..461	CDD:212518	142/317 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0123
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1484694at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100220
Panther	1	1.100	-	-	O	PTHR48252
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.820