DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HDAC4 and HDAC11

DIOPT Version :9

Sequence 1:	NP_001259507.1	Gene:	HDAC4 / 32278	FlyBaseID:	FBgn0041210	Length:	1269	Species:	Drosophila melanogaster
Sequence 2:	NP_079103.2	Gene:	HDAC11 / 79885	HGNCID:	19086	Length:	347	Species:	Homo sapiens

Alignment Length:	411	Identity:	94/411 - (22%)
Similarity:	153/411 - (37%)	Gaps:	107/411 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   817 LYASQLRNHQPSASG----SPPHKVTTGLAYDPLMLKHSCICGDNAQHPEHSGRLQSVWARLNET 877
            |:.:||..|.|....    ||.:.:|              ..|....||..:|:...|...|.|.
Human     2 LHTTQLYQHVPETRWPIVYSPRYNIT--------------FMGLEKLHPFDAGKWGKVINFLKEE 52

  Fly   878 DLVKRCDRLRARKATQEELQTVH-----------------TEAHAMLFGSN---QCQLSRPKLEN 922
            .|:.....:.||:|::|:|..||                 ||...::|..|   |.::.||
Human    53 KLLSDSMLVEAREASEEDLLVVHTRRYLNELKWSFAVATITEIPPVIFLPNFLVQRKVLRP---- 113

  Fly   923 TLSASFVRLSCGGLGVDLDTTWNEHHTATAARMAA--GCVIDLALKTAKGDLRNGFAVVRPPGHH 985
                  :|...||             |..|.::|.  |..|::.         .||       ||
Human   114 ------LRTQTGG-------------TIMAGKLAVERGWAINVG---------GGF-------HH 143

  Fly   986 AEANLAMGFCFFNSIAIAAKLLRQRMPEVRRILIVDWDVHHGNGTQQAFYQSPDILYLSIH-RHD 1049
            ..::...|||.:..|.:|.|.|.:|:..:.|..|:|.|.|.|||.::.|.....:..:.:: ||
Human   144 CSSDRGGGFCAYADITLAIKFLFERVEGISRATIIDLDAHQGNGHERDFMDDKRVYIMDVYNRH- 207

  Fly  1050 DGNFFPGTGGPTECGSGAGLGFNVNISWSGALNPPLGDAEYIAAFRTVVMPIARSFNPDIVLVSS 1114
               .:||     :..:...:...|.:.|.      ..|.||:......:....:...||:|:.::
Human   208 ---IYPG-----DRFAKQAIRRKVELEWG------TEDDEYLDKVERNIKKSLQEHLPDVVVYNA 258

  Fly  1115 GFDAATGHPAPLGGYHVSPACFGFMTRE--LLQLANGK---VVLALEGGYD---LAAICDSAQEC 1171
            |.|...|.  .|||..:|||  |.:.|:  :.::..|:   :::...|||.   ...|.||....
Human   259 GTDILEGD--RLGGLSISPA--GIVKRDELVFRMVRGRRVPILMVTSGGYQKRTARIIADSILNL 319

  Fly  1172 VRALLGDPAAPIAKAELERPP 1192
            ....|..|.:|...|:....|
Human   320 FGLGLIGPESPSVSAQNSDTP 340

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HDAC4	NP_001259507.1	iSH2_PI3K_IA_R	43..>87	CDD:304922
HDAC4	NP_001259507.1	HDAC_classIIa	837..1211	CDD:212544	87/387 (22%)
HDAC11	NP_079103.2	Histone deacetylase	14..326		85/383 (22%)
HDAC11	NP_079103.2	HDAC_classIV	35..319	CDD:212519	80/341 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0123
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810