DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HDAC4 and hdac7a

DIOPT Version :9

Sequence 1:	NP_001259507.1	Gene:	HDAC4 / 32278	FlyBaseID:	FBgn0041210	Length:	1269	Species:	Drosophila melanogaster
Sequence 2:	XP_021325750.1	Gene:	hdac7a / 798603	ZFINID:	ZDB-GENE-150129-1	Length:	960	Species:	Danio rerio

Alignment Length:	1150	Identity:	404/1150 - (35%)
Similarity:	556/1150 - (48%)	Gaps:	302/1150 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   131 QHRQQLHQQQQQHQQQQQQQQHQQQQQQ-----QQARGRDGMKLKQNCSANASPEVKQILNCFIL 190
            ||..|..|||.|..||...:||.|.|:|     ||.:.:|    |...||.||..|||.|...||
Zfish    77 QHCSQYSQQQLQRIQQYNMEQHLQDQEQAKQQLQQLKHKD----KSQQSAVASALVKQKLAQVIL 137

  Fly   191 SRKSQAAA---SNGTTTTSP---YRNRGVVKSSSGESLPAGTVTSAHPYKIPQPPPSLLKYESDF 249
            .::.|.|.   :|....:||   ||:...:|.:...|:..                |:|.:.|.|
Zfish   138 KKQKQQAVLERTNSNPLSSPSVAYRSENTLKHTGLWSVLL----------------SMLAFCSCF 186

  Fly   250 PLRKTASEPNL-LKIRLKQSVIERKARI-----GGPAGARRHERLLQAAQRRQQKNSVLTNCNST 308
                :|||||| :|.:||:.:..||:.:     ..||...|....|.::          .:.:||
Zfish   187 ----SASEPNLKVKHKLKKHLNTRKSPLTRKESAPPAVKHRTPDALDSS----------PSSSST 237

  Fly   309 PDSGPNSPPSAAALAVGVVGSRGSPTSAPIQEENEEGSQYQPGQRSSINDLPLFSSPSLPNISLG 373
            |.||.:||..:.....|     .|.:|:.:..|    :|....|..|::...:.:|.|||.|:||
Zfish   238 PVSGCSSPNDSLPTENG-----ASSSSSSLSHE----AQRLLLQDGSLSHFTIQNSSSLPTITLG 293

  Fly   374 RPHLPNSAQAHAQVNAQVAAQAQAQAQAQAQAHAMFAALAAAQGGCGQPGYYNPLGMAFVGRQPA 438
            .|       |:::|...:::....:....:.:..:...|          |...||....:..:|:
Zfish   294 LP-------ANSKVEGDLSSLKLGRVPLVSGSSPLLLPL----------GVEEPLMQPVLILEPS 341

  Fly   439 PLAMIPATGIAPQQPSPVVRSASATSTSSSQASLVGDVAPPQAHAASTILPSSSSYMQQLGSVAG 503
            .|...|...:....|.|:..|||...             .|.:...|..||.|...:|
Zfish   342 GLVHTPLLAVPGLGPVPLQFSASGPH-------------KPLSRTRSEPLPQSPGRLQ------- 386

  Fly   504 SGVNLHAAAVAAAAAAAAAAGSLPPTNSHGHGHGSHAHPHPHAHGHGHGHGHGIYAGHQHNVPIT 568
                                                  ||||           :....||:..:
Zfish   387 --------------------------------------PHPH-----------LLQQQQHSTHL- 401

  Fly   569 DAQVAQVHLHKQGHRPLGRTQSAPLPLGHPMLTGAVQLNVVQTHYENSEAERQAYEHQVVNQKVR 633
                  :|..||...           ||..|...:.:..:.|...|:.::|.
Zfish   402 ------LHRLKQNTH-----------LGKLMQKSSEKPRLRQIPSEDMDSEE------------- 436

  Fly   634 QTVLTRSGAAAAAAAAAGVSVVREAQLKEEDDDSAAEVMDLTDKKKPPKTVLTSTIATSTSQNLP 698
                    |..||..|.......|:|.:.|:.:   |.|:|
Zfish   437 --------AGPAAGDAHQGRGRAESQREMENQE---EQMNL------------------------ 466

  Fly   699 EALAAAAAAAAYRAPHNASSNSASATKSGIKLRDQEYLQQQREQLLLLQQEEELAKSLM------ 757
                          .|....|.:...::      |::|||.|.|   ..|.|.||..:|
Zfish   467 --------------QHTLILNQSRLWET------QKHLQQLRRQ---TAQMETLAVPMMLGGGQH 508

  Fly   758 RPLSRTLSSPLVPLGPHGLSQIPDTGQQPAPIATSSSADHIPPVNLSLPHRQHRQLMSTLYASQL 822
            ||||||.|||                      |::|         |:||.:       ||
Zfish   509 RPLSRTQSSP----------------------ASTS---------LTLPEK-------TL----- 530

  Fly   823 RNHQPSAS-GSPPH---KVTTGLAYDPLMLKHSCICGDNAQHPEHSGRLQSVWARLNETDLVKRC 883
                |.|: ..||.   :.||||.||..||||.|.||||:.||||:||:||:|:||.|..|..:|
Zfish   531 ----PLATPAEPPQSQPRFTTGLVYDSQMLKHQCTCGDNSSHPEHAGRIQSIWSRLQERGLRGQC 591

  Fly   884 DRLRARKATQEELQTVHTEAHAMLFGSNQCQLSRPKLENTLSAS------FVRLSCGGLGVDLDT 942
            :.:|.||||.||||:||||.|.:|:|:|  .|:|.||:|...|.      ||.|.|||:|||.||
Zfish   592 ESIRGRKATLEELQSVHTERHVLLYGTN--PLNRLKLDNRKLAGILSQRMFVMLPCGGVGVDNDT 654

  Fly   943 TWNEHHTATAARMAAGCVIDLALKTAKGDLRNGFAVVRPPGHHAEANLAMGFCFFNSIAIAAKLL 1007
            .|||.||:||:|||||.|.:||.:.|||:|:|||||||||||||:.:..||||||||:|||||.|
Zfish   655 IWNEMHTSTASRMAAGSVTELAFRVAKGELKNGFAVVRPPGHHADPSNPMGFCFFNSVAIAAKQL 719

  Fly  1008 RQRMPEVRRILIVDWDVHHGNGTQQAFYQSPDILYLSIHRHDDGNFFPGTGGPTECGSGAGLGFN 1072
            :|:: ...:|||||||||||||||:.||..|.:||:|:||:|:||||||:|||.|.|||||.|||
Zfish   720 QQKL-SASKILIVDWDVHHGNGTQEIFYNDPSVLYISLHRYDNGNFFPGSGGPAEVGSGAGEGFN 783

  Fly  1073 VNISWSGALNPPLGDAEYIAAFRTVVMPIARSFNPDIVLVSSGFDAATGHPAPLGGYHVSPACFG 1137
            ||::|:|.|.||:.||||:|||||||||||:.|:||:||||||||||.|||:|||||.|:..|||
Zfish   784 VNVAWTGGLEPPMADAEYLAAFRTVVMPIAQEFSPDVVLVSSGFDAAEGHPSPLGGYKVTAKCFG 848

  Fly  1138 FMTRELLQLANGKVVLALEGGYDLAAICDSAQECVRALLGDPAAPIAKAELERPPCQNAINTLQK 1202
            ||||:|:.||.|:||||||||:||.||||:::.||.|||| ...|:.::.|.:.|..:.:.:||:
Zfish   849 FMTRQLMTLAGGRVVLALEGGHDLTAICDASEACVSALLG-LEEPLPESTLLQTPSASGVLSLQR 912

  Fly  1203 TIAIQQTHWPCVRMLEHTVGLSALETLKVEHDESETINAMAGLSM 1247
            .:.|...:|..::.|..|||:|.|...:.:.:|::|:||||.||:
Zfish   913 VLQIHSQYWSSLKPLMGTVGMSFLGAQRKDCEETDTVNAMASLSV 957

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HDAC4	NP_001259507.1	iSH2_PI3K_IA_R	43..>87	CDD:304922
HDAC4	NP_001259507.1	HDAC_classIIa	837..1211	CDD:212544	233/379 (61%)
hdac7a	XP_021325750.1	HDAC_classIIa	545..921	CDD:212544	233/379 (61%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	444	1.000	Domainoid score	I508
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D119187at33208
OrthoFinder	1	1.000	-	-		FOG0001001
OrthoInspector	1	1.000	-	-		otm25625
orthoMCL	1	0.900	-	-		OOG6_100220
Panther	1	1.100	-	-	O	PTHR48252
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.920