DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment HDAC4 and hdac7b

DIOPT Version :9

Sequence 1:NP_001259507.1 Gene:HDAC4 / 32278 FlyBaseID:FBgn0041210 Length:1269 Species:Drosophila melanogaster
Sequence 2:XP_017212138.1 Gene:hdac7b / 792596 ZFINID:ZDB-GENE-131127-113 Length:751 Species:Danio rerio


Alignment Length:799 Identity:281/799 - (35%)
Similarity:398/799 - (49%) Gaps:175/799 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly   578 HKQGHRPLGR----TQSAPLPL-GHPMLTGA-VQLNVVQTHYENSEAERQAYEHQVVNQKVRQTV 636
            |.|.||.|.|    ||...|.| .....||| ..|:|          .|:.||: :.|::.|   
Zfish     3 HHQQHRTLERGRRSTQEDKLSLRKESEQTGAGCSLSV----------RRKLYEY-ICNKQHR--- 53

  Fly   637 LTRSGAAAAAAAAAGVSV-VREAQLKEEDDD---SAAE-VMDLTDKKKPPKTVLTSTIATSTSQN 696
                       .:||..: .||...:|||:.   :|:| ::.|..|:.  .|...:.:...||  
Zfish    54 -----------TSAGQDIQQRELDRQEEDNPLRRTASEPILKLRSKRS--MTGRQNPLQRKTS-- 103

  Fly   697 LPEALAAAAAAAAYRAPHNASSNSASATKSGI--KLRDQEYLQQQREQLLLLQQEEELAKSLMRP 759
                     |..|...|.:.:.:::|||.|.:  ::..||.:|.........:::..|..|:..|
Zfish   104 ---------APPAVGDPDSMAVSASSATVSSLDNQMNRQELIQTTTYSASSGKEDSPLQISIQHP 159

  Fly   760 L-----SRTLSSPLV-PLGPHGLSQIPDTGQQ-----PAPIATSSSAD---------HIPPVNLS 804
            :     :.|..:|.| .|.||..:.   ||||     ..|:..|.||.         |.|...|.
Zfish   160 VLWPAYAATAYNPQVFTLYPHIFTV---TGQQWPPMPHRPLIKSQSAPSYIQQYTHIHTPAYTLV 221

  Fly   805 LP-------------------------------------------------------HRQHRQLM 814
            .|                                                       :||..||.
Zfish   222 QPMYQQQWPQETFQQHTLPEKVSVGPAWPESPGDLGRFRKRTSEEVRISSQSPLESCNRQGVQLK 286

  Fly   815 STL--------------------YASQLRNHQPSASGSPPHKVTTGLAYDPLMLKHSCICGDNAQ 859
            ..|                    :.::|.:|..||........||||.|:  |:||.|.|.|::.
Zfish   287 ENLEWRHKIFHQQVSRVHSFPDTFDTRLSSHSASALDMRKPNFTTGLVYE--MMKHRCDCRDSSC 349

  Fly   860 HPEHSGRLQSVWARLNETDLVKRCDRLRARKATQEELQTVHTEAHAMLFGSNQCQLSRPKLENTL 924
            ....:.|:.|:|:||.|..|..:|..|:.|.||.|||.:||:|.....|...:...|:       
Zfish   350 GLHEADRVTSIWSRLQECGLRSQCKLLKGRSATVEELLSVHSEELVCFFTGPEPYRSQ------- 407

  Fly   925 SASFVRLSCGGLGVDLDTTWNEHHTATAARMAAGCVIDLALKTAKGDLRNGFAVVRPPGHHAEAN 989
                         :|:.|.|.....:.|.:||.|.|.:|||..|:||||||||||.||||||..:
Zfish   408 -------------MDIGTMWKNPRNSEALKMAVGSVTELALCVARGDLRNGFAVVTPPGHHASRS 459

  Fly   990 LAMGFCFFNSIAIAAKLLRQRMPEVRRILIVDWDVHHGNGTQQAFYQSPDILYLSIHRHDDGNFF 1054
            ..:....|||:|||||.|:::: :|::|||||||||||:||:..||..|.:||:|:||:|||.||
Zfish   460 QTLDSIVFNSVAIAAKQLQEQL-KVKKILIVDWDVHHGSGTESIFYTDPSVLYISLHRYDDGAFF 523

  Fly  1055 PGTGGPTECGSGAGLGFNVNISWSGALNPPLGDAEYIAAFRTVVMPIARSFNPDIVLVSSGFDAA 1119
            .|||.|:..|...|.|:|||::|||.|.||:|||||:|||||||||||..|:|::||||:|||||
Zfish   524 NGTGDPSRVGCDVGRGYNVNVAWSGGLRPPMGDAEYLAAFRTVVMPIAHEFSPNVVLVSAGFDAA 588

  Fly  1120 TGHPAPLGGYHVSPACFGFMTRELLQLANGKVVLALEGGYDLAAICDSAQECVRALLGDPAAPIA 1184
            .||||.||||.|||.|||::|::|::||.|:|||.|||||:|.::||::|.||.||||:...|::
Zfish   589 EGHPAALGGYRVSPKCFGWLTQKLMELAEGRVVLVLEGGYELVSLCDASQACVSALLGNEPEPLS 653

  Fly  1185 KAELERPPCQNAINTLQKTIAIQQTHWPCVRMLEHTVGLSALETLKVEHDESETINAMAGLSMQS 1249
            :.||.|.||.||:.:|:|.:.:|..||..||.:.:||.||.::..:.....||....::||:|..
Zfish   654 EVELLRSPCANAVCSLEKVLHVQSLHWRSVRSMLNTVSLSYVKAERRVSAGSEAALVLSGLNMTV 718

  Fly  1250 MHRTLSRDDSEEPMDQDET 1268
            .||   |....||::.|||
Zfish   719 PHR---RQLPNEPVEDDET 734

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HDAC4NP_001259507.1 iSH2_PI3K_IA_R 43..>87 CDD:304922
HDAC_classIIa 837..1211 CDD:212544 186/373 (50%)
hdac7bXP_017212138.1 Arginase_HDAC 329..680 CDD:327367 186/373 (50%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0123
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D119187at33208
OrthoFinder 1 1.000 - - FOG0001001
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR48252
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
54.920

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