Protein Alignment HDAC4 and hdac7b

DIOPT Version :10

• Sequence 1: NP_001259507.1
• Gene: HDAC4 / 32278
• FlyBaseID: FBgn0041210
• Length: 1269
• Species: Drosophila melanogaster
• Sequence 2: XP_017212138.1
• Gene: hdac7b / 792596
• ZFINID: ZDB-GENE-131127-113
• Length: 751
• Species: Danio rerio
• Alignment Length: 799
• Identity: 281/799 - (35%)
• Similarity: 398/799 - (49%)
• Gaps: 175/799 - (21%)

  Fly   578 HKQGHRPLGR----TQSAPLPL-GHPMLTGA-VQLNVVQTHYENSEAERQAYEHQVVNQKVRQTV 636
            |.|.||.|.|    ||...|.| .....||| ..|:|          .|:.||: :.|::.|
Zfish     3 HHQQHRTLERGRRSTQEDKLSLRKESEQTGAGCSLSV----------RRKLYEY-ICNKQHR--- 53

  Fly   637 LTRSGAAAAAAAAAGVSV-VREAQLKEEDDD---SAAE-VMDLTDKKKPPKTVLTSTIATSTSQN 696
                       .:||..: .||...:|||:.   :|:| ::.|..|:.  .|...:.:...||
Zfish    54 -----------TSAGQDIQQRELDRQEEDNPLRRTASEPILKLRSKRS--MTGRQNPLQRKTS-- 103

  Fly   697 LPEALAAAAAAAAYRAPHNASSNSASATKSGI--KLRDQEYLQQQREQLLLLQQEEELAKSLMRP 759
                     |..|...|.:.:.:::|||.|.:  ::..||.:|.........:::..|..|:..|
Zfish   104 ---------APPAVGDPDSMAVSASSATVSSLDNQMNRQELIQTTTYSASSGKEDSPLQISIQHP 159

  Fly   760 L-----SRTLSSPLV-PLGPHGLSQIPDTGQQ-----PAPIATSSSAD---------HIPPVNLS 804
            :     :.|..:|.| .|.||..:.   ||||     ..|:..|.||.         |.|...|.
Zfish   160 VLWPAYAATAYNPQVFTLYPHIFTV---TGQQWPPMPHRPLIKSQSAPSYIQQYTHIHTPAYTLV 221

  Fly   805 LP-------------------------------------------------------HRQHRQLM 814
            .|                                                       :||..||.
Zfish   222 QPMYQQQWPQETFQQHTLPEKVSVGPAWPESPGDLGRFRKRTSEEVRISSQSPLESCNRQGVQLK 286

  Fly   815 STL--------------------YASQLRNHQPSASGSPPHKVTTGLAYDPLMLKHSCICGDNAQ 859
            ..|                    :.::|.:|..||........||||.|:  |:||.|.|.|::.
Zfish   287 ENLEWRHKIFHQQVSRVHSFPDTFDTRLSSHSASALDMRKPNFTTGLVYE--MMKHRCDCRDSSC 349

  Fly   860 HPEHSGRLQSVWARLNETDLVKRCDRLRARKATQEELQTVHTEAHAMLFGSNQCQLSRPKLENTL 924
            ....:.|:.|:|:||.|..|..:|..|:.|.||.|||.:||:|.....|...:...|:
Zfish   350 GLHEADRVTSIWSRLQECGLRSQCKLLKGRSATVEELLSVHSEELVCFFTGPEPYRSQ------- 407

  Fly   925 SASFVRLSCGGLGVDLDTTWNEHHTATAARMAAGCVIDLALKTAKGDLRNGFAVVRPPGHHAEAN 989
                         :|:.|.|.....:.|.:||.|.|.:|||..|:||||||||||.||||||..:
Zfish   408 -------------MDIGTMWKNPRNSEALKMAVGSVTELALCVARGDLRNGFAVVTPPGHHASRS 459

  Fly   990 LAMGFCFFNSIAIAAKLLRQRMPEVRRILIVDWDVHHGNGTQQAFYQSPDILYLSIHRHDDGNFF 1054
            ..:....|||:|||||.|:::: :|::|||||||||||:||:..||..|.:||:|:||:|||.||
Zfish   460 QTLDSIVFNSVAIAAKQLQEQL-KVKKILIVDWDVHHGSGTESIFYTDPSVLYISLHRYDDGAFF 523

  Fly  1055 PGTGGPTECGSGAGLGFNVNISWSGALNPPLGDAEYIAAFRTVVMPIARSFNPDIVLVSSGFDAA 1119
            .|||.|:..|...|.|:|||::|||.|.||:|||||:|||||||||||..|:|::||||:|||||
Zfish   524 NGTGDPSRVGCDVGRGYNVNVAWSGGLRPPMGDAEYLAAFRTVVMPIAHEFSPNVVLVSAGFDAA 588

  Fly  1120 TGHPAPLGGYHVSPACFGFMTRELLQLANGKVVLALEGGYDLAAICDSAQECVRALLGDPAAPIA 1184
            .||||.||||.|||.|||::|::|::||.|:|||.|||||:|.::||::|.||.||||:...|::
Zfish   589 EGHPAALGGYRVSPKCFGWLTQKLMELAEGRVVLVLEGGYELVSLCDASQACVSALLGNEPEPLS 653

  Fly  1185 KAELERPPCQNAINTLQKTIAIQQTHWPCVRMLEHTVGLSALETLKVEHDESETINAMAGLSMQS 1249
            :.||.|.||.||:.:|:|.:.:|..||..||.:.:||.||.::..:.....||....::||:|..
Zfish   654 EVELLRSPCANAVCSLEKVLHVQSLHWRSVRSMLNTVSLSYVKAERRVSAGSEAALVLSGLNMTV 718

  Fly  1250 MHRTLSRDDSEEPMDQDET 1268
            .||   |....||::.|||
Zfish   719 PHR---RQLPNEPVEDDET 734

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HDAC4	NP_001259507.1	ClassIIa_HDAC_Gln-rich-N	43..>87	CDD:421006
		HDAC_classIIa	837..1211	CDD:212544	186/373 (50%)
hdac7b	XP_017212138.1	Arginase_HDAC	329..680	CDD:450134	186/373 (50%)