DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HDAC4 and Hdac9

DIOPT Version :9

Sequence 1:	NP_001259507.1	Gene:	HDAC4 / 32278	FlyBaseID:	FBgn0041210	Length:	1269	Species:	Drosophila melanogaster
Sequence 2:	XP_006515324.1	Gene:	Hdac9 / 79221	MGIID:	1931221	Length:	1100	Species:	Mus musculus

Alignment Length:	1311	Identity:	444/1311 - (33%)
Similarity:	651/1311 - (49%)	Gaps:	337/1311 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 ITPATLTLDFK-PHPAVD-------IDQQIMELKKSQELQKQRLINSFQEQSKQMELEHKLQLEH 82
            |:|..|..|.: ..|.||       :.|:::.:::.|::|||.||..||:|.:.:..:|:.||:.
Mouse    54 ISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQE 118

  Fly    83 KYQKQPTNKRFSLELIVIIQFAVNSHGAFQELRNESMVTAAAAAVAQEQHRQQLHQQQQQHQQQQ 147
            ..:.|                        |||          .|:.|:|...:..|:.:|.:|:|
Mouse   119 HIKLQ------------------------QEL----------LAIKQQQELLEKEQKLEQQRQEQ 149

  Fly   148 QQQQHQQQQQQQQARGRDGMKLKQNCSANASPEVKQILNCFILSRKSQAAASNGTTTTSPYRNRG 212
            :.::|:::||....||:|..:.:    |.||.||||.|..|:||:    :|:..|.|..  :|..
Mouse   150 EVERHRREQQLPPLRGKDRGRER----AVASTEVKQKLQEFLLSK----SATKDTPTNG--KNHS 204

  Fly   213 VVKSSSGESLPAGTVTSAHPYKIPQPPPSL------LKY--------ESDFPLRKTASEPNL-LK 262
            |.:.      |....|:||...:.|..|.|      .||        :.||||||||||||| ::
Mouse   205 VGRH------PKLWYTAAHHTSLDQSSPPLSGTSPSYKYTLPGAQDSKDDFPLRKTASEPNLKVR 263

  Fly   263 IRLKQSVIERKARIGGPAGARRHERLLQAAQRRQQKNSVLTNCNSTPDSGPNSPPSAAALAVGVV 327
            .||||.|.||::   .|...|:...|:.:.::|..:.:..:..:|:|.|||:||.:
Mouse   264 SRLKQKVAERRS---SPLLRRKDGNLVTSFKKRVFEVAESSVSSSSPGSGPSSPNN--------- 316

  Fly   328 GSRGSPTSAPIQEENEEGS--------QYQPGQR-----SSINDLPLFSSPSLPNISLGRPHLPN 379
            |..|:.|      |||..:        |..|.||     .|:|.|.|::|||||||:||.|.:|
Mouse   317 GPAGNVT------ENEASALPPTPHPEQLVPQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVP- 374

  Fly   380 SAQAHAQVNAQVAAQAQAQAQAQAQAHAMFAALAAAQGGCGQPGYYNPLGMAFVGRQPAPLAMIP 444
                 :.:||..:.:.:.:.:.|                              :.||..||
Mouse   375 -----SPLNASNSLKDKQKCETQ------------------------------MLRQGVPL---- 400

  Fly   445 ATGIAPQQPSPVVRSASATSTSSSQASLVGDVAPPQAHAA--STILPSSSSYMQQLGSVAGSGVN 507
                    ||   :..|:.:.|||...:..:..|..:|.|  ..:|.......|:| .||| ||.
Mouse   401 --------PS---QYGSSIAASSSHVHVAMEGKPTSSHQALLQHLLLKEQMRQQKL-LVAG-GVP 452

  Fly   508 LHAAAVAAAAAAAAAAGSLPPTNSHGHGHGSHAHPHPHAHGHGHGHGHGIYAGHQHNVPITDAQV 572
            ||..:..|.....:                      |...|             .|.:|
Mouse   453 LHPQSPLATKERIS----------------------PGIRG-------------THKLP------ 476

  Fly   573 AQVHLHKQGHRPLGRTQSAPLPLGHPMLTGAVQLNVVQTHYENSEAERQAYEHQV-VNQKVRQTV 636
                    .||||.||||||||     .:...||.:.|.|.:..|.::| |:.|: :|:.:.:::
Mouse   477 --------RHRPLNRTQSAPLP-----QSTLAQLVIQQQHQQFLEKQKQ-YQQQIHMNKLLSKSI 527

  Fly   637 --LTRSGAAAAAAAAAGVSVVREAQLKEEDDDSAAEVMDLTDKKKPPKTVLTSTIATSTSQNLPE 699
              |.:.|           |.:.||:.:.:.|.|..:.....|          ::..:.:|..:.:
Mouse   528 EQLKQPG-----------SHLEEAEEELQGDQSMEDRAASKD----------NSARSDSSACVED 571

  Fly   700 ALAAAAAAAAYRAPHNASSNSASATKSGIKLRDQEYLQQQREQLLLLQQEEELAKSLMRP----- 759
            .|....|......|.::..::        ::::.|.    .||...:||...|..|..|.
Mouse   572 TLGQVGAVKVKEEPVDSDEDA--------QIQEMEC----GEQAAFMQQPPLLESSRARSLSVHQ 624

  Fly   760 ---------------LSRTLSSPLVPLGPHGLSQIPDTGQQPAPIATSSSADHIPPVNLSLPHRQ 809
                           ||||.|||...:.||..:..|
Mouse   625 TLAAVGTDGLEKHGLLSRTHSSPAASMSPHPAADCP----------------------------- 660

  Fly   810 HRQLMSTLYASQLRNHQPSASGSPPHKVTTGLAYDPLMLKHSCICGDNAQHPEHSGRLQSVWARL 874
                           .|||::        ||:|||||||||.||||.:..||||:||:||:|:||
Mouse   661 ---------------RQPSSA--------TGIAYDPLMLKHQCICGSSTTHPEHAGRIQSIWSRL 702

  Fly   875 NETDLVKRCDRLRARKATQEELQTVHTEAHAMLFGSNQCQLSRPKLE-NTLSAS-----FVRLSC 933
            .||.|:.:|:|::.|||:.||:|.||:|.|::|:|::  .|...||: .||...     |..|.|
Mouse   703 QETGLLSKCERIQGRKASLEEIQLVHSEHHSLLYGTS--PLDGQKLDPRTLLGDDSRKFFSSLPC 765

  Fly   934 GGLGVDLDTTWNEHHTATAARMAAGCVIDLALKTAKGDLRNGFAVVRPPGHHAEANLAMGFCFFN 998
            ||||||.||.|||.|::.|||||.||||:||.|.|.|:|:||||||||||||||.:.||||||||
Mouse   766 GGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVVRPPGHHAEESAAMGFCFFN 830

  Fly   999 SIAIAAKLLRQRMPEVRRILIVDWDVHHGNGTQQAFYQSPDILYLSIHRHDDGNFFPGTGGPTEC 1063
            |:||.||.||.:: .:.:|||||.|||||||||||||..|.|||:|:||:|:||||||:|.|.|.
Mouse   831 SVAITAKYLRDQL-NISKILIVDLDVHHGNGTQQAFYADPSILYISLHRYDEGNFFPGSGAPNEV 894

  Fly  1064 GSGAGLGFNVNISWSGALNPPLGDAEYIAAFRTVVMPIARSFNPDIVLVSSGFDAATGHPAPLGG 1128
            |.|.|.|:||||:|:|.|:||:||.||:.||||||||:||.|:||:||||:||||..||..||||
Mouse   895 GVGLGEGYNVNIAWTGGLDPPMGDVEYLEAFRTVVMPVAREFDPDMVLVSAGFDALEGHTPPLGG 959

  Fly  1129 YHVSPACFGFMTRELLQLANGKVVLALEGGYDLAAICDSAQECVRALLGDPAAPIAKAELERPPC 1193
            |.|:..|||.:|::|:.||||:|.||||||:||.||||:::.|:.||||:...|:.:..|.:...
Mouse   960 YKVTAKCFGHLTKQLMTLANGRVALALEGGHDLTAICDASEACINALLGNEPGPLEEDALHQSVN 1024

  Fly  1194 QNAINTLQKTIAIQQTHWPCVRMLEHTVGLSALETLKVEHDESETINAMAGLSMQSMHRTLSRDD 1258
            .||..:|||||.||..:|..::|:....| .||...::: :|:||::|:|.|:: .:.:..:::|
Mouse  1025 TNAAASLQKTIDIQSKYWKSIKMVAAARG-GALPASQLQ-EETETVSALASLTV-DVEQPFAQED 1086

  Fly  1259 SE---EPMDQD 1266
            ..   |||:::
Mouse  1087 GRTAGEPMEEE 1097

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HDAC4	NP_001259507.1	iSH2_PI3K_IA_R	43..>87	CDD:304922	13/43 (30%)
HDAC4	NP_001259507.1	HDAC_classIIa	837..1211	CDD:212544	226/379 (60%)
Hdac9	XP_006515324.1	ClassIIa_HDAC9_Gln-rich-N	71..160	CDD:197399	27/122 (22%)
Hdac9	XP_006515324.1	HDAC_classIIa	665..1042	CDD:212544	226/387 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843206
Domainoid	1	1.000	119	1.000	Domainoid score	I5776
eggNOG	1	0.900	-	-		E1_COG0123
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46994
OrthoDB	1	1.010	-	-		D119187at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100220
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	8	7.620