DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HDAC4 and Hdac8

DIOPT Version :9

Sequence 1:	NP_001259507.1	Gene:	HDAC4 / 32278	FlyBaseID:	FBgn0041210	Length:	1269	Species:	Drosophila melanogaster
Sequence 2:	XP_006528338.1	Gene:	Hdac8 / 70315	MGIID:	1917565	Length:	386	Species:	Mus musculus

Alignment Length:	360	Identity:	97/360 - (26%)
Similarity:	163/360 - (45%)	Gaps:	53/360 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   826 QPSASGSPPHKVTTGLAYDPLMLKHSCICGDNAQHPEHSGRLQSVWARLNETDLVKRCDRLRARK 890
            :|:.||   |.:.....|.|   ::..||....:.|:.:..:.|:   :....|.|:...::.:.
Mouse     6 EPANSG---HSLPPVYIYSP---EYVSICDSLVKVPKRASMVHSL---IEAYALHKQMRIVKPKV 61

  Fly   891 ATQEELQTVHTEAHAMLFGSNQCQLSRPKLE----NTLSASFVRLSCGGLGVDLDTTWNEHHTAT 951
            |:.||:.|.||:|:..       .|.:...|    :..|..:      |||.|...|......|.
Mouse    62 ASMEEMATFHTDAYLQ-------HLQKVSQEGDEDHPDSIEY------GLGYDCPATEGIFDYAA 113

  Fly   952 A----ARMAAGCVIDLALKTAKGDLRNGFAVVRPPGHHAEANLAMGFCFFNSIAIAAKLLRQRMP 1012
            |    ...||.|:||...|.|. :...|:       |||:.:.|.|||:.|...:....||::..
Mouse   114 AIGGGTITAAQCLIDGKCKVAI-NWSGGW-------HHAKKDEASGFCYLNDAVLGILRLRRKFD 170

  Fly  1013 EVRRILIVDWDVHHGNGTQQAFYQSPDILYLSIHRHDDGNFFPGTGGPTECGSGAGLGFNVNISW 1077
               |||.||.|:|||:|.:.||..:..::.:|:|:...| ||||||..::.|.|.|..::||:
Mouse   171 ---RILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPG-FFPGTGDMSDVGLGKGRYYSVNV-- 229

  Fly  1078 SGALNPPLGDAEYIAAFRTVVMPIARSFNPDIVLVSSGFDAATGHPAPLGGYHVSPACFGFMTRE 1142
              .:...:.|.:|.....:|:..:.::|||..|::..|.|...|.  |:..::::|...|...:.
Mouse   230 --PIQDGIQDEKYYHICESVLKEVYQAFNPKAVVLQLGADTIAGD--PMCSFNMTPVGIGKCLKY 290

  Fly  1143 LLQLANGKVVLALEGGYDLAAICDSAQECVRALLG 1177
            :||.....::|. .|||:||    :...|...|.|
Mouse   291 VLQWQLATLILG-GGGYNLA----NTARCWTYLTG 320

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HDAC4	NP_001259507.1	iSH2_PI3K_IA_R	43..>87	CDD:304922
HDAC4	NP_001259507.1	HDAC_classIIa	837..1211	CDD:212544	93/349 (27%)
Hdac8	XP_006528338.1	HDAC8	16..370	CDD:212524	93/347 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0123
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810