Protein Alignment HDAC4 and Hdac9

DIOPT Version :9

• Sequence 1: NP_001259507.1
• Gene: HDAC4 / 32278
• FlyBaseID: FBgn0041210
• Length: 1269
• Species: Drosophila melanogaster
• Sequence 2: XP_017449847.1
• Gene: Hdac9 / 687001
• RGDID: 1310748
• Length: 1094
• Species: Rattus norvegicus
• Alignment Length: 1296
• Identity: 448/1296 - (34%)
• Similarity: 651/1296 - (50%)
• Gaps: 301/1296 - (23%)

  Fly    26 ITPATLTLDFK-PHPAVD-------IDQQIMELKKSQELQKQRLINSFQEQSKQMELEHKLQLEH 82
            |:|..|..|.: ..|.||       :.|:::.:::.|::|||.||..||:|.:.:..:|:.||:.
  Rat    42 ISPLDLRTDLRMMMPVVDPVVREKQLQQELLLIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQE 106

  Fly    83 KYQKQPTNKRFSLELIVIIQFAVNSHGAFQELRNESMVTAAAAAVAQEQHRQQLHQQQQQHQQQQ 147
            ..:.|                        |||          .|:.|:|...:..|:.:|.:|:|
  Rat   107 HIKLQ------------------------QEL----------LAIKQQQELLEKEQKLEQQRQEQ 137

  Fly   148 QQQQHQQQQQQQQARGRD-GMKLKQNCSANASPEVKQILNCFILSRKSQAAASNGTTTTSPYRNR 211
            :.::|:::||....||:| |.:.|::..|.||.||||.|..|:||:    :|:..|.|..  :|.
  Rat   138 EVERHRREQQLPPLRGKDRGRESKRHQGAVASTEVKQKLQEFLLSK----SATKDTPTNG--KNH 196

  Fly   212 GVVKSSSGESLPAGTVTSAHPYKIPQPPPSL------LKY--------ESDFPLRKTASEPNL-L 261
            .|.:.      |....|:||...:.|..|.|      .||        :.||||||||||||| :
  Rat   197 SVGRH------PKLWYTAAHHTSLDQSSPPLSGTSPSYKYTLPGAQDTKDDFPLRKTASEPNLKV 255

  Fly   262 KIRLKQSVIERKARIGGPAGARRHERLLQAAQRRQQKNSVLTNCNSTPDSGPNSPPSAAALAVGV 326
            :.||||.|.||::   .|...|:...|:.:.::|..:.:..:..:|:|.|||:||.:
  Rat   256 RSRLKQKVAERRS---SPLLRRKDGNLVTSFKKRVFEVAESSVSSSSPGSGPSSPNN-------- 309

  Fly   327 VGSRGSPTSAPIQEENEEG--------SQYQPGQR-----SSINDLPLFSSPSLPNISLGRPHLP 378
             |..|:.|      |||..        .|..|.||     .|:|.|.|::|||||||:||.|.:|
  Rat   310 -GPAGNVT------ENEASVLPPTPHPEQLVPQQRILIHEDSMNLLSLYTSPSLPNITLGLPAVP 367

  Fly   379 NSAQAHAQVNAQVAAQAQAQAQAQAQAHAMFAALAAAQGGCGQPGYYNPLGMAFVGRQPAPLAMI 443
            :...|...:..:...:.|...|                 |...||.|
  Rat   368 SPLSASNSLKDKQKCETQMLRQ-----------------GVPLPGQY------------------ 397

  Fly   444 PATGIAPQQPSPVVRSASATSTSSSQASLVGDVAPPQAHAA--STILPSSSSYMQQLGSVAGSGV 506
             .:|||               .|||.|.:..:..|..:|.|  ..:|.......|:| .||| ||
  Rat   398 -GSGIA---------------ASSSHAHVAMEGKPNSSHQALLQHLLLKEQMRQQKL-LVAG-GV 444

  Fly   507 NLHAAAVAAAAAAAAAAGSLPPTNSHGHGHGSHAHPHPHAHGHGHGHGHGIYAGHQHNVPITDAQ 571
            .||..:..|.....:                      |...|             .|.:|
  Rat   445 PLHPQSPLATKERIS----------------------PGIRG-------------THKLP----- 469

  Fly   572 VAQVHLHKQGHRPLGRTQSAPLPLGHPMLTGAVQLNVVQTHYENSEAERQAYEHQV-VNQKVRQT 635
                     .||||.||||||||     .:...||.:.|.|.:..|.::| |:.|: :|:.:.::
  Rat   470 ---------RHRPLNRTQSAPLP-----QSTLAQLVIQQQHQQFLEKQKQ-YQQQIHMNKLLSKS 519

  Fly   636 V--LTRSGAAAAAAAAAGVSVVREAQLKEEDDDSAAEVMDLTDKKKPPKTVLTSTIATSTSQNLP 698
            :  |.:.|           |.:.||:.:.:.|.:..|.....|          |.....:|..:.
  Rat   520 IEQLKQPG-----------SHLEEAEEELQGDQAMEERATSKD----------SGTGKDSSACVE 563

  Fly   699 EALAAAAAAAAYRAPHNASSNSASATKSGIKLRDQEYLQQQREQLLLLQQEEELAKSLMRPLS-- 761
            :.|....|......|.::..::        ::::.|.    .||...:||...|..|..|.||
  Rat   564 DTLGQVGAVKVKEEPVDSDEDA--------QMQEMEC----GEQAAFMQQTPLLESSHTRALSVH 616

  Fly   762 --RTLSSPLVPLGPHGLSQIPDTGQQPAPIATSSSADHIPPVNLSLPHRQHRQLMSTLYASQLRN 824
              |..::.:..|..|||  :..|...|||..:...|...|
  Rat   617 QARLAAAGIDGLEKHGL--LSRTHSSPAPSMSPHPAADCP------------------------- 654

  Fly   825 HQPSASGSPPHKVTTGLAYDPLMLKHSCICGDNAQHPEHSGRLQSVWARLNETDLVKRCDRLRAR 889
            .||:::        ||:|||.|||||.||||::..||||:||:||:|:||.||.|:.:|:|::.|
  Rat   655 RQPASA--------TGIAYDCLMLKHQCICGNSTTHPEHAGRIQSIWSRLQETGLLNKCERIQGR 711

  Fly   890 KATQEELQTVHTEAHAMLFGSNQCQLSRPKLE-NTLSAS-----FVRLSCGGLGVDLDTTWNEHH 948
            ||:.||:|.||:|.|::|:|::  .|...||: .||...     |..|.|||||||.||.|||.|
  Rat   712 KASLEEIQLVHSEHHSLLYGTS--PLDGQKLDPRTLLGDDSRKFFSSLPCGGLGVDSDTIWNELH 774

  Fly   949 TATAARMAAGCVIDLALKTAKGDLRNGFAVVRPPGHHAEANLAMGFCFFNSIAIAAKLLRQRMPE 1013
            ::.|||||.||||:||.|.|.|:|:||||||||||||||.:.|||||||||:||.||.||.:: .
  Rat   775 SSGAARMAVGCVIELASKVASGELKNGFAVVRPPGHHAEESAAMGFCFFNSVAITAKYLRDQL-N 838

  Fly  1014 VRRILIVDWDVHHGNGTQQAFYQSPDILYLSIHRHDDGNFFPGTGGPTECGSGAGLGFNVNISWS 1078
            :.:|||||.|||||||||||||..|.|||:|:||:|:||||||:|.|.|.|.|.|.|:||||:|:
  Rat   839 ISKILIVDLDVHHGNGTQQAFYADPSILYISLHRYDEGNFFPGSGAPNEVGVGLGEGYNVNIAWT 903

  Fly  1079 GALNPPLGDAEYIAAFRTVVMPIARSFNPDIVLVSSGFDAATGHPAPLGGYHVSPACFGFMTREL 1143
            |.|:||:||.||:.||||||||:||.|:||:||||:||||..||..|||||.|:..|||.:|::|
  Rat   904 GGLDPPMGDVEYLEAFRTVVMPVAREFDPDMVLVSAGFDALEGHTPPLGGYKVTAKCFGHLTKQL 968

  Fly  1144 LQLANGKVVLALEGGYDLAAICDSAQECVRALLGDPAAPIAKAELERPPCQNAINTLQKTIAIQQ 1208
            :.||||:|.||||||:||.||||:::.|:.||||:....:.:..|.:....||..:|||||.||.
  Rat   969 MTLANGRVALALEGGHDLTAICDASEACINALLGNEPGSLEEDVLHQSVNTNAAASLQKTIEIQS 1033

  Fly  1209 THWPCVRMLEHTVGLSALETLKVEHDESETINAMAGLSMQSMHRTLSRDDSE---EPMDQD 1266
            .:|..::|:....| .||...::: :|:||::|:|.|:: .:.:..:::|..   |||:::
  Rat  1034 KYWKSIKMVAVARG-CALPASQLQ-EETETVSALASLTV-DVEQPFAQEDGRTAGEPMEEE 1091

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HDAC4	NP_001259507.1	iSH2_PI3K_IA_R	43..>87	CDD:304922	13/43 (30%)
		HDAC_classIIa	837..1211	CDD:212544	224/379 (59%)
Hdac9	XP_017449847.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166346711
Domainoid	1	1.000	454	1.000	Domainoid score	I480
eggNOG	1	0.900	-	-		E1_COG0123
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	576	1.000	Inparanoid score	I1005
OMA	1	1.010	-	-		QHG46994
OrthoDB	1	1.010	-	-		D119187at33208
OrthoFinder	1	1.000	-	-		FOG0001001
OrthoInspector	1	1.000	-	-		otm46126
orthoMCL	1	0.900	-	-		OOG6_100220
Panther	1	1.100	-	-	O	PTHR48252
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X933
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.770