DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HDAC4 and hdac1

DIOPT Version :9

Sequence 1:	NP_001259507.1	Gene:	HDAC4 / 32278	FlyBaseID:	FBgn0041210	Length:	1269	Species:	Drosophila melanogaster
Sequence 2:	NP_001025564.1	Gene:	hdac1 / 594953	XenbaseID:	XB-GENE-479583	Length:	480	Species:	Xenopus tropicalis

Alignment Length:	446	Identity:	105/446 - (23%)
Similarity:	175/446 - (39%)	Gaps:	115/446 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   860 HPEHSGRLQSVWARLNETDLVKRCDRLRARKATQEELQTVHTEAHAMLFGS----NQCQLSR--- 917
            ||....|::.....|....|.::.:..|..||:.||:...|::.:.....|    |..:.|:
Frog    28 HPIKPHRIRMTHNLLLNYGLYRKMEIYRPHKASAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQ 92

  Fly   918 --------PKLENTLSASFVRLSCGGLGVDLDTTWNEHHTATAARMAAGCVIDLALKTAKGDLRN 974
                    |..:...  .|.:||.|| .|......|:..|..:...:.|.
Frog    93 RFNVGEDCPVFDGLF--EFCQLSTGG-SVASSVKLNKQQTDISVNWSGGL--------------- 139

  Fly   975 GFAVVRPPGHHAEANLAMGFCFFNSIAIA-AKLLRQRMPEVRRILIVDWDVHHGNGTQQAFYQSP 1038
                     |||:.:.|.|||:.|.|.:| .:||:..    :|:|.:|.|:|||:|.::|||.:.
Frog   140 ---------HHAKKSEASGFCYVNDIVLAILELLKYH----QRVLYIDIDIHHGDGVEEAFYTTD 191

  Fly  1039 DILYLSIHRHDDGNFFPGTGGPTECGSGAGLGFNVNISWSGALNPPLGDAEYIAAFRTVVMPIAR 1103
            .::.:|.|::  |.:|||||...:.|:|.|..:.||.    .|...:.|..|.|.|:.|:..:..
Frog   192 RVMTVSFHKY--GEYFPGTGDLRDIGAGKGKYYAVNY----PLRDGIDDESYEAIFKPVMSKVME 250

  Fly  1104 SFNPDIVLVSSGFDAATGHPAPLGGYHVSPACFGFMTR------ELLQLANGKVVLALEGGYDL- 1161
            .:.|..|::..|.|:.:|.  .||       ||....:      |.::..|..:::...|||.:
Frog   251 MYQPSAVVLQCGADSLSGD--RLG-------CFNLTIKGHAKCVEFIKTFNLPLLMLGGGGYTIR 306

  Fly  1162 -AAICDSAQECVRALLGDPAAP-------------------IAKAELERPPCQNAINTLQKTIAI 1206
             .|.|.:.:..| ||  |...|                   |:.:.:..   ||....|:|   |
Frog   307 NVARCWTYETAV-AL--DSEIPNELPYNDYFEYFGPDFKLHISPSNMTN---QNTNEYLEK---I 362

  Fly  1207 QQTHWPCVRMLEHTVGLSALETLKVEHDESETINAMAGLSMQSMHRTLSRDDSEEP 1262
            :|..:..:|||.|..|:.                 |..:...|:|.....:|.|:|
Frog   363 KQRLFENLRMLPHAPGVQ-----------------MQAIPEDSVHDDSGEEDEEDP 401

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HDAC4	NP_001259507.1	iSH2_PI3K_IA_R	43..>87	CDD:304922
HDAC4	NP_001259507.1	HDAC_classIIa	837..1211	CDD:212544	94/393 (24%)
hdac1	NP_001025564.1	HDAC1	4..374	CDD:212534	96/400 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000