Protein Alignment HDAC4 and hdac4

DIOPT Version :9

• Sequence 1: NP_001259507.1
• Gene: HDAC4 / 32278
• FlyBaseID: FBgn0041210
• Length: 1269
• Species: Drosophila melanogaster
• Sequence 2: XP_005172586.1
• Gene: hdac4 / 568877
• ZFINID: ZDB-GENE-061013-95
• Length: 1052
• Species: Danio rerio
• Alignment Length: 1317
• Identity: 454/1317 - (34%)
• Similarity: 653/1317 - (49%)
• Gaps: 325/1317 - (24%)

  Fly     3 SPDDRIPIHDLPSEAGSDERLLHITPATLTLDFK---PHPAVDID-------------------- 44
            |..|.:|..:.|.|......:.||.|..:::...   |..|:.:|
Zfish     5 SRPDGLPSKEQPLELLKPSGVNHIPPVDVSVALPLQVPPSAIPMDLRVDHQFALAPTDPAQREHQ 69

  Fly    45 --QQIMELKKSQELQKQRLINSFQEQSKQMELEHKLQL-EH-KYQKQPTNKRFSLELIVIIQFAV 105
              |:::.||:.|::|:|.||..||.|.:|:..:|:.|| || |:|:         :|:.:
Zfish    70 LQQELLALKQKQQIQRQLLIEEFQRQHEQLSRQHEAQLQEHVKHQQ---------DLLAL----- 120

  Fly   106 NSHGAFQELRNESMVTAAAAAVAQEQHRQQL--HQQQQQHQQQQQQQQHQQQQQQQQ-----ARG 163
                                     :|:|:|  ||::.:..:|:|:.:.||::|:.|     .||
Zfish   121 -------------------------KHQQELLEHQRKLERHRQEQEMEKQQREQKLQLLKNKERG 160

  Fly   164 RDGMKLKQNCSANASPEVKQILNCFILSRKSQAA--ASNGTTTTSPYRNRGVVKSSS-GESLPAG 225
            ::        ||.||.|||..|..|:|::|...|  :.|....:.|....|..:.|| .:|.|..
Zfish   161 QE--------SAVASTEVKMRLQEFVLNKKKALAQRSLNHCLPSDPRYWYGKTQHSSLDQSSPPQ 217

  Fly   226 TVTSAHPYKIPQPPPSLLKYE--SDFPLRKTASEPNL-LKIRLKQSVIERKA-----RIGGPAGA 282
            |..|.:.:      |.|..|:  .||||||||||||| |:.||||.|.||::     |..||...
Zfish   218 TGISTYNH------PVLGMYDPKDDFPLRKTASEPNLKLRSRLKQKVSERRSSPLLRRKDGPITT 276

  Fly   283 RRHERLLQAAQRRQQKNSVLTNCNSTPDSGPNSPPSAAALAVGVVGSRGSPTSAPIQEENEEGSQ 347
            .: :|.|..|:         :.|:|.|.|||:||.:::.......|..||.:::.::...   :.
Zfish   277 AK-KRSLDMAE---------SACSSAPGSGPSSPNNSSNNITNENGIAGSISNSAVEPSL---AH 328

  Fly   348 YQPGQRSSINDLPLFSSPSLPNISLGRPHLPNSAQAHAQVNAQVAAQAQAQAQAQAQAHAMFAAL 412
            ...|:...::.|.|::|||||||:||.|....|:.|..|.:..
Zfish   329 RLTGREGPVSQLSLYTSPSLPNITLGLPATGPSSVASGQQDGD---------------------- 371

  Fly   413 AAAQGGCGQPGYYNPLGMAFVGRQPAPLAMIPATGIAPQQPSPVVRSASATSTSSSQASLVGDVA 477
                            .||..|.||.    ||.|       :|.:
Zfish   372 ----------------RMAVPGLQPG----IPIT-------TPFM-------------------- 389

  Fly   478 PPQAHAASTILPSSSSYMQQLGSVAGSGVNLHAAAVAAAAAAAAAAGSLP--PTNSHGHGHGSHA 540
             |.||..|.:  ::||..::.|| |.:.:..|...:..:||..:....|.  |..||.
Zfish   390 -PGAHLPSYL--AASSLERESGS-AHNTLLQHMVLLEQSAAQNSLVAGLSGVPLQSHS------- 443

  Fly   541 HPHPHAHGHGHGHGHGIYAGHQHNVPITDAQVAQVHLHK-QGHRPLGRTQSAPLPLGHPMLTGAV 604
                                                :|| :.|||||||||||||.....|.
Zfish   444 ------------------------------------IHKLRQHRPLGRTQSAPLPQNSQALQ--- 469

  Fly   605 QLNVVQTHYENSEAERQAYEHQ---VVNQKVRQTVLTRSGAAAAAAAAAGVSVVREAQLKEEDDD 666
            ||.|.|.|.:..|..:|.::.|   :....|:.:...|                :.....||.::
Zfish   470 QLVVQQQHQQFLEKHKQQFQQQQLHISKMMVKPSEPNR----------------QHESHPEETEE 518

  Fly   667 SAAEVMDLTDKKKPPKTVLTSTIATSTSQNLPEALAAAAAAAAYRAPHNASSNSASATKSGIKLR 731
            ...|...|.|...|                               .||..:.......:     :
Zfish   519 ELREHQGLGDPADP-------------------------------LPHGVTIKQEPPDE-----Q 547

  Fly   732 DQEYLQQQREQLLLLQQEEELAKSLMRPLSRTLSSPLVPLGPHGLSQIPDTGQQPAPIATSSSAD 796
            |:::  ||||:    |.||||   |.|..:..|....:    |.|... ....:.|.::.|.
Zfish   548 DEDF--QQRER----QAEEEL---LFRQQALLLEQQRI----HQLRNY-QASMEAAGLSVSF--- 595

  Fly   797 HIPPVNLSLPHRQHRQLMSTLYASQLRNHQPSASGSPPHK--VTTGLAYDPLMLKHSCICGDNAQ 859
               ||:..|...|.....:|.         |.....||.|  .||||.||.||.||.|:||::..
Zfish   596 ---PVHRPLSRAQSSPASATF---------PIVVQEPPAKPRFTTGLVYDTLMQKHQCMCGNSNI 648

  Fly   860 HPEHSGRLQSVWARLNETDLVKRCDRLRARKATQEELQTVHTEAHAMLFGSNQCQLSRPKLENTL 924
            ||||:||:||:|:||.||.|..:|:.:|.||||.|||||||:|||.:|:|:|..   |.||::::
Zfish   649 HPEHAGRIQSIWSRLQETGLRGQCECIRGRKATLEELQTVHSEAHVLLYGTNPL---RQKLDSSV 710

  Fly   925 SASFVRLSCGGLGVDLDTTWNEHHTATAARMAAGCVIDLALKTAKGDLRNGFAVVRPPGHHAEAN 989
            :..||||.|||:|||.||.|||.|:::|||:|.|.|:||..|.|.|:||||||||||||||||.:
Zfish   711 TPMFVRLPCGGIGVDSDTIWNEVHSSSAARLAVGSVVDLVFKVASGELRNGFAVVRPPGHHAEES 775

  Fly   990 LAMGFCFFNSIAIAAKLLRQRMPEVRRILIVDWDVHHGNGTQQAFYQSPDILYLSIHRHDDGNFF 1054
            ..||||:|||:|||||||:||: .|.:|||||||||||||||||||..|::||||:||:||||||
Zfish   776 TPMGFCYFNSVAIAAKLLQQRL-NVSKILIVDWDVHHGNGTQQAFYSDPNVLYLSLHRYDDGNFF 839

  Fly  1055 PGTGGPTECGSGAGLGFNVNISWSGALNPPLGDAEYIAAFRTVVMPIARSFNPDIVLVSSGFDAA 1119
            ||:|.|.|.|.|.|:|||||::::|.|.||:|||:|:||||:||||||..|:||:|||||||||.
Zfish   840 PGSGAPDEVGIGPGVGFNVNMAFTGGLEPPMGDADYLAAFRSVVMPIANEFSPDVVLVSSGFDAV 904

  Fly  1120 TGHPAPLGGYHVSPACFGFMTRELLQLANGKVVLALEGGYDLAAICDSAQECVRALLGDPAAPIA 1184
            .|||.|||||.::..|||::|::|:.||.|::|||||||:||.||||:::.||.||||:...||.
Zfish   905 EGHPPPLGGYKLTAKCFGYLTKQLMGLAGGRLVLALEGGHDLTAICDASEACVSALLGNELDPIP 969

  Fly  1185 KAELERPPCQNAINTLQKTIAIQQTHWPCVRMLEHTVGLSALETLKVEHDESETINAMAGLSMQS 1249
            :..|::.|..|||.:::|.:.:|..:|..::....|:|.|..|..:.|::|:||:.|||.||:.:
Zfish   970 EDILQQRPNANAIQSMEKVLEVQSKYWRSLQRSVSTLGYSLREAQRCENEEAETVTAMASLSVAN 1034

  Fly  1250 MHRTLSRDDSEEPMDQD 1266
            .|  :.:...||||:::
Zfish  1035 KH--MGKRPEEEPMEEE 1049

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HDAC4	NP_001259507.1	iSH2_PI3K_IA_R	43..>87	CDD:304922	20/67 (30%)
		HDAC_classIIa	837..1211	CDD:212544	228/373 (61%)
hdac4	XP_005172586.1	ClassIIa_HDAC4_Gln-rich-N	62..151	CDD:197398	30/127 (24%)
		PKK	68..187	CDD:289257	44/165 (27%)
		Arginase_HDAC	623..1025	CDD:302587	238/405 (59%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	444	1.000	Domainoid score	I508
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	659	1.000	Inparanoid score	I747
OMA	1	1.010	-	-		QHG46994
OrthoDB	1	1.010	-	-		D119187at33208
OrthoFinder	1	1.000	-	-		FOG0001001
OrthoInspector	1	1.000	-	-		otm25625
orthoMCL	1	0.900	-	-		OOG6_100220
Panther	1	1.100	-	-	LDO	PTHR48252
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X933
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.980