DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HDAC4 and hdac6

DIOPT Version :9

Sequence 1:	NP_001259507.1	Gene:	HDAC4 / 32278	FlyBaseID:	FBgn0041210	Length:	1269	Species:	Drosophila melanogaster
Sequence 2:	XP_009302026.1	Gene:	hdac6 / 565482	ZFINID:	ZDB-GENE-030131-3232	Length:	1081	Species:	Danio rerio

Alignment Length:	681	Identity:	208/681 - (30%)
Similarity:	297/681 - (43%)	Gaps:	176/681 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   667 SAAEVMDLTDKKKPPKTVLTSTIATSTSQNLPE------------------ALAAAAAAAAYRA- 712
            |...|:.|.||      |:||.:....|.|.|.                  |:||..|...:|.
Zfish   164 SVGSVLQLVDK------VMTSQLRNGFSINRPPGHHAQADKMNGFCMFNNLAIAARYAQKRHRVQ 222

  Fly   713 ---------------------------------------PHNASSNSASA--------------T 724
                                                   ||...|:|:|.              .
Zfish   223 RVLIVDWDVHHGQGIQYIFEEDPSVLYFSVHRYEDGSFWPHLKESDSSSVGSGAGQGYNINLPWN 287

  Fly   725 KSGIKLRDQEYLQQQ---------REQLLL---------------LQQEEELAKSLMRPLSRTLS 765
            |.|::..|.....||         :.||:|               :|...|....|...|.....
Zfish   288 KVGMESGDYITAFQQLLLPVAYEFQPQLVLVAAGFDAVIGDPKGGMQVSPECFSILTHMLKGVAQ 352

  Fly   766 SPLVPLGPHGLSQIPDTGQ-----------QPAPIATSSSADHIPPVNLSLPHRQHRQLMSTLY- 818
            ..|| |...|...:..|.:           .|.|...||.|    |...:|  :...:.:|.||
Zfish   353 GRLV-LALEGGYNLQSTAEGVCASMRSLLGDPCPHLPSSGA----PCESAL--KSISKTISDLYP 410

  Fly   819 ---ASQLRNHQPSASGSP-PHKV---------TTGLAYDPLMLKHSCICGDNAQHPEHSGRLQSV 870
               :.|.....|.:..|| |..|         .|||.||..|:.|..:.  ::.|||...|:..:
Zfish   411 FWKSLQTFEGGPLSEVSPLPAPVCAEVKVSSPITGLVYDQRMMLHHNMW--DSHHPELPQRISRI 473

  Fly   871 WARLNETDLVKRCDRLRARKATQEELQTVHTEAHAMLFGSNQCQLSRPKLENTLSASFVRLSCGG 935
            ::|..|..|:.||.|:.||.||:|||...|:..|..:..|::..  :|:..|.
Zfish   474 FSRHEELRLLSRCHRIPARLATEEELALCHSSKHISIIKSSEHM--KPRDLNR------------ 524

  Fly   936 LGVDLDTTWNEHHTATAARMAAGCVIDLALKTAKGDLRNGFAVVRPPGHHAEANLAMGFCFFNSI 1000
            ||.:.::.:..:.:.|.|.:|||...:.|.....|.:||..|:|||||||||.:.|.||||||:.
Zfish   525 LGDEYNSIFISNESYTCALLAAGSCFNSAQAILTGQVRNAVAIVRPPGHHAEKDTACGFCFFNTA 589

  Fly  1001 AIAAKLLRQRMPEVRRILIVDWDVHHGNGTQQAFYQSPDILYLSIHRHDDGNFFPGT--GGPTEC 1063
            |:.|:..:....|..|:||||||||||||||..|.:...:||:|:||::||.|||.:  ....:.
Zfish   590 ALTARYAQSITRESLRVLIVDWDVHHGNGTQHIFEEDDSVLYISLHRYEDGAFFPNSEDANYDKV 654

  Fly  1064 GSGAGLGFNVNISWSGALNPPLGDAEYIAAFRTVVMPIARSFNPDIVLVSSGFDAATGHPAPLGG 1128
            |.|.|.|:||||.|:|.   .:||.||:|||..:||||||.|.|::||||:|||||.|.  ||||
Zfish   655 GLGKGRGYNVNIPWNGG---KMGDPEYMAAFHHLVMPIAREFAPELVLVSAGFDAARGD--PLGG 714

  Fly  1129 YHVSPACFGFMTRELLQLANGKVVLALEGGYDLAAICDSAQECVRALLGDPAAPIAKAELERPPC 1193
            :.|:|..:..:|.:|:.||.|:|::.|||||:|.:|.:|...|...||||           .||.
Zfish   715 FQVTPEGYAHLTHQLMSLAAGRVLIILEGGYNLTSISESMSMCTSMLLGD-----------SPPS 768

  Fly  1194 QNAINTLQ--KTIAIQ---QTH---WPCVRM 1216
            .:.:..|:  .|::|.   :.|   |..:|:
Zfish   769 LDHLTPLKTSATVSINNVLRAHAPFWSSLRV 799

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HDAC4	NP_001259507.1	iSH2_PI3K_IA_R	43..>87	CDD:304922
HDAC4	NP_001259507.1	HDAC_classIIa	837..1211	CDD:212544	153/392 (39%)
hdac6	XP_009302026.1	HDAC6-dom1	76..412	CDD:212545	48/260 (18%)
		HDAC6-dom2	448..798	CDD:212527	150/381 (39%)
		zf-UBP	999..1061	CDD:280334
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0123
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1484694at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100220
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2991
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.750