Protein Alignment HDAC4 and HDAC8

DIOPT Version :9

• Sequence 1: NP_001259507.1
• Gene: HDAC4 / 32278
• FlyBaseID: FBgn0041210
• Length: 1269
• Species: Drosophila melanogaster
• Sequence 2: XP_011529288.3
• Gene: HDAC8 / 55869
• HGNCID: 13315
• Length: 403
• Species: Homo sapiens
• Alignment Length: 429
• Identity: 106/429 - (24%)
• Similarity: 180/429 - (41%)
• Gaps: 84/429 - (19%)

  Fly   826 QPSASGSPPHKVTTGLAYDPLMLKHSCICGDNAQHPEHSGRLQSVWARLNETDLVKRCDRLRARK 890
            :|:.||   ..:.....|.|   ::..:|...|:.|:.:..:.|:   :....|.|:...::.:.
Human     6 EPADSG---QSLVPVYIYSP---EYVSMCDSLAKIPKRASMVHSL---IEAYALHKQMRIVKPKV 61

  Fly   891 ATQEELQTVHTEAHAMLFGSNQCQLSRPKLE----NTLSASFVRLSCGGLGVDLDTTWNEHHTAT 951
            |:.||:.|.||:|:..       .|.:...|    :..|..:      |||.|...|......|.
Human    62 ASMEEMATFHTDAYLQ-------HLQKVSQEGDDDHPDSIEY------GLGYDCPATEGIFDYAA 113

  Fly   952 ----AARMAAGCVIDLALKTAKGDLRNGFAVVRPPG--HHAEANLAMGFCFFNSIAIAAKLLRQR 1010
                |...||.|:||...|.|          :...|  |||:.:.|.|||:.|...:....||::
Human   114 AIGGATITAAQCLIDGMCKVA----------INWSGGWHHAKKDEASGFCYLNDAVLGILRLRRK 168

  Fly  1011 MPEVRRILIVDWDVHHGNGTQQAFYQSPDILYLSIHRHDDGNFFPGTGGPTECGSGAGLGFNVNI 1075
            .   .|||.||.|:|||:|.:.||..:..::.:|:|:...| ||||||..::.|.|.|..::||:
Human   169 F---ERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPG-FFPGTGDVSDVGLGKGRYYSVNV 229

  Fly  1076 SWSGALNPPLGDAEYIAAFRTVVMPIARSFNPDIVLVSSGFDAATGHPAPLGGYHVSPACFGFMT 1140
                .:...:.|.:|.....:|:..:.::|||..|::..|.|...|.  |:..::::|...|...
Human   230 ----PIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGD--PMCSFNMTPVGIGKCL 288

  Fly  1141 RELLQLANGKVVLALEGGYDLAAICDSAQECVRALLGDPAAPIAKAELE---------------- 1189
            :.:||.....::|. .|||:||    :...|...|.|........:|:.
Human   289 KYILQWQLATLILG-GGGYNLA----NTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEI 348

  Fly  1190 RPPC---QNAINTLQKTIAIQQTHWPCVRMLEHTVGLSA 1225
            .|.|   :|..:.:|:.:...:..||        ||..|
Human   349 TPSCRPDRNEPHRIQQILNYIKEKWP--------VGFGA 379

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HDAC4	NP_001259507.1	iSH2_PI3K_IA_R	43..>87	CDD:304922
		HDAC_classIIa	837..1211	CDD:212544	98/402 (24%)
HDAC8	XP_011529288.3	HDAC8	16..371	CDD:212524	98/398 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0123
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810