DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HDAC4 and hdac5

DIOPT Version :9

Sequence 1:	NP_001259507.1	Gene:	HDAC4 / 32278	FlyBaseID:	FBgn0041210	Length:	1269	Species:	Drosophila melanogaster
Sequence 2:	XP_685659.5	Gene:	hdac5 / 557486	ZFINID:	ZDB-GENE-121219-3	Length:	1128	Species:	Danio rerio

Alignment Length:	1301	Identity:	458/1301 - (35%)
Similarity:	645/1301 - (49%)	Gaps:	301/1301 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 PSEAGSDERLLHITPATLTLDFKPHPAVDIDQQIMELKKSQELQKQRLINSFQEQSKQMELEHKL 78
            |.:..:|.||..::....:|..|     .:..:::.||:.||||||.|...||:|.:.:..:|::
Zfish    78 PVDLRTDPRLSALSAVDPSLREK-----QLQHELLLLKQQQELQKQLLFAEFQKQHEVLTRQHEV 137

  Fly    79 QLEHKYQKQPTNKRFSLELIVIIQFAVNSHGAFQELRNESMVTAAAAAVAQEQHRQQLHQQQQQH 143
            ||:                              :.|:.:..:.||        .|||..:|:::.
Zfish   138 QLQ------------------------------EHLKQQQEILAA--------KRQQELEQKRKL 164

  Fly   144 QQQQQQQQHQQQQQQQQARGRDGMKLKQNCSANASPEVKQILNCFILSRKSQAAASNGTTTTSPY 208
            :||:.::..:|:.:||....|:..|.|:  ||.||.|||..|..|:||:|.  ....|...:.|.
Zfish   165 EQQRHEEMEKQRLEQQLIMLRNKEKGKE--SAIASTEVKLKLQEFLLSKKE--PGPGGLNHSFPQ 225

  Fly   209 RNRGVVKSSSGESLPAGTVTSAHP--YKIPQPPPSLLKYE--SDFPLRKTASEPNL-LKIRLKQS 268
            :..|...:|..:|.|..:.|...|  ||:   ||.|..||  .||||||||||||| ::.||||.
Zfish   226 KCWGAHHTSLEQSSPPQSNTPGTPPSYKL---PPLLGSYEGKDDFPLRKTASEPNLKVRSRLKQK 287

  Fly   269 VIERKARIGGPAGARRHERLLQAAQRRQQKNSVLTNCNSTPDSGPNSPPSAAALAVGVVGSRGSP 333
            |.||::   .|...|:...::...::|..:.||.:.|:|.|.|||:||.|:..    .:...||.
Zfish   288 VAERRS---SPLLRRKDGTVISTFKKRAIEISVSSMCSSAPGSGPSSPNSSNC----AIAENGSS 345

  Fly   334 TSAPIQEENEEGSQYQPGQRSSIND-----LPLFSSPSLPNISLGRPHLPNSAQAHAQVNAQVAA 393
            .|.|    |....|.:...:|...|     |.|::||||||||||.|     |.||.....:::|
Zfish   346 GSVP----NIHAEQLRSLHQSLTGDGAPSPLSLYTSPSLPNISLGLP-----ANAHITAPQKLSA 401

  Fly   394 QAQAQAQAQAQAHAMFAALAAAQGGCGQPGYYNPLGMAFVGRQPAPLAMIPATGIAPQQPSPVVR 458
            |.:|:.|         ...:..|||.        |...|:.....|..:  :|| ||..|.|
Zfish   402 QQEAERQ---------TIQSLRQGGA--------LTGKFISTSSLPTCL--STG-APHDPEP--- 443

  Fly   459 SASATSTSSSQASLVGDV-APPQAHAASTILPSSSSYMQQLGSVAGSGVNLHAAAVAAAAAAAAA 522
             .:|:::.||.:||:..| ...||...|.:|  :.....|...|.|..|:.:...|
Zfish   444 -PAASNSHSSHSSLLQHVLLLEQARQQSALL--AVPMYGQSPLVTGERVSNNMRTV--------- 496

  Fly   523 AGSLPPTNSHGHGHGSHAHPHPHAHGHGHGHGHGIYAGHQHNVPITDAQVAQVHLHKQGHRPLGR 587
             ..||                                                     .||||.|
Zfish   497 -NKLP-----------------------------------------------------RHRPLSR 507

  Fly   588 TQSAPLPLGHPMLTGAVQLNVVQTHYENSEAERQAYEHQVVNQKVRQ--TVLTRSGAAAAAAAAA 650
            ||||||    |....|:|..|:|          |.::|.:..||..|  .:|::
Zfish   508 TQSAPL----PQTPQALQHLVMQ----------QQHQHFLEKQKHYQLNKILSK----------- 547

  Fly   651 GVSVVREAQL-KEEDDDSAAEVMDLTDKK-------------------KPPKTVLTSTIATSTSQ 695
            |..:.|:... .||.::...|..::.|::                   .||...:......||..
Zfish   548 GTDLPRQPPTHPEETEEELTETAEMQDERGEGPDHVREGLQKDSSGETTPPSERIVPLKGESTES 612

  Fly   696 NLPEALAAAAAAAAYRAPHNASSNSASATKSGIKLRD-------QEYLQQQR-EQLLLLQQEEEL 752
            :|.|                     .......::||:       .:||.||. :||.:.|....:
Zfish   613 DLEE---------------------EDDEDEAVELRECDEDAPYGQYLDQQHVQQLNVFQASLSI 656

  Fly   753 AKSLMRPLSRTLSSPLVPLGPHGLSQIPDTGQQPAPIATSSSADHIPPVNLSLPHRQHRQLMSTL 817
            .....|||.|..|||:.       |.:..|.....||
Zfish   657 TGMPHRPLGRAQSSPVT-------SSLKGTTLNEVPI---------------------------- 686

  Fly   818 YASQLRNHQPSASGSPPHKVTTGLAYDPLMLKHSCICGDNAQHPEHSGRLQSVWARLNETDLVKR 882
                            .|..||||.||..||||.|:||:...||||:||:||||:||.||.|:.|
Zfish   687 ----------------KHLFTTGLVYDTFMLKHQCMCGNTNIHPEHAGRIQSVWSRLQETGLLGR 735

  Fly   883 CDRLRARKATQEELQTVHTEAHAMLFGS---NQCQLSRPKLENTLSAS-FVRLSCGGLGVDLDTT 943
            |:|:|.||||.:|:||||:|.|.:|:|:   |:.:|...||...:|.. :..|.|||:|||.||.
Zfish   736 CERIRGRKATLDEIQTVHSEYHTLLYGTSPLNRQKLDSKKLLGPISQKMYAVLPCGGIGVDSDTV 800

  Fly   944 WNEHHTATAARMAAGCVIDLALKTAKGDLRNGFAVVRPPGHHAEANLAMGFCFFNSIAIAAKLLR 1008
            |||.|::.|.|||.||||:||.|.|.|:|:||||||||||||||.:.|||||||||:||.||||:
Zfish   801 WNEMHSSGAVRMAVGCVIELAFKVAAGELKNGFAVVRPPGHHAEESTAMGFCFFNSVAITAKLLQ 865

  Fly  1009 QRMPEVRRILIVDWDVHHGNGTQQAFYQSPDILYLSIHRHDDGNFFPGTGGPTECGSGAGLGFNV 1073
            |:: .|.:|||:|||:|||||||||||..|::||:|:||:||||||||:|.|.|.|.|.|.||||
Zfish   866 QKL-GVGKILIIDWDIHHGNGTQQAFYNDPNVLYISLHRYDDGNFFPGSGAPEEVGVGPGEGFNV 929

  Fly  1074 NISWSGALNPPLGDAEYIAAFRTVVMPIARSFNPDIVLVSSGFDAATGHPAPLGGYHVSPACFGF 1138
            ||:|:|.:.||:||.||:.||||||||||..|:||:||||:||||..||.:|||||:|:..|||.
Zfish   930 NIAWTGGVEPPMGDVEYLTAFRTVVMPIANEFSPDVVLVSAGFDAVEGHQSPLGGYNVTAKCFGH 994

  Fly  1139 MTRELLQLANGKVVLALEGGYDLAAICDSAQECVRALLGDPAAPIAKAELERPPCQNAINTLQKT 1203
            :|::|::||.|:||||||||:||.||||:::.||.|||||...|:....|::.||..|..:|::.
Zfish   995 LTKQLMKLAGGRVVLALEGGHDLTAICDASESCVEALLGDELNPLPLTVLQQKPCPKATASLERV 1059

  Fly  1204 IAIQQTHWPCVRMLEHTVGLSALETLKVEHDESETINAMAGLSMQSMHRTLSRDDS---EEPMDQ 1265
            |.||..||..::.|..|||.|.|:..:.|.||::|:.|||.|::.:..:|.|.:.|   ||||::
Zfish  1060 IEIQSKHWTSLQRLAPTVGQSLLDAQRREKDEADTLTAMASLTVDNEQQTTSTETSRSAEEPMEE 1124

  Fly  1266 D 1266
            :
Zfish  1125 E 1125

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HDAC4	NP_001259507.1	iSH2_PI3K_IA_R	43..>87	CDD:304922	15/43 (35%)
HDAC4	NP_001259507.1	HDAC_classIIa	837..1211	CDD:212544	226/377 (60%)
hdac5	XP_685659.5	ClassIIa_HDAC5_Gln-rich-N	94..181	CDD:197400	28/129 (22%)
hdac5	XP_685659.5	HDAC5	688..1107	CDD:212531	243/419 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	444	1.000	Domainoid score	I508
eggNOG	1	0.900	-	-		E1_COG0123
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	659	1.000	Inparanoid score	I747
OMA	1	1.010	-	-		QHG46994
OrthoDB	1	1.010	-	-		D119187at33208
OrthoFinder	1	1.000	-	-		FOG0001001
OrthoInspector	1	1.000	-	-		otm25625
orthoMCL	1	0.900	-	-		OOG6_100220
Panther	1	1.100	-	-	O	PTHR48252
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2991
SonicParanoid	1	1.000	-	-		X933
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.870