DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HDAC4 and hdac3

DIOPT Version :9

Sequence 1:	NP_001259507.1	Gene:	HDAC4 / 32278	FlyBaseID:	FBgn0041210	Length:	1269	Species:	Drosophila melanogaster
Sequence 2:	NP_001016883.1	Gene:	hdac3 / 549637	XenbaseID:	XB-GENE-481106	Length:	428	Species:	Xenopus tropicalis

Alignment Length:	464	Identity:	109/464 - (23%)
Similarity:	176/464 - (37%)	Gaps:	104/464 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   838 TTGLAYDPLMLKHSCICGDNAQHPEHSGRLQSVWARLNETDLVKRCDRLRARKATQEELQTVHTE 902
            |....|||.:.......|    ||....||....:.:....|.|:....:..:|:|.::...|:|
Frog     4 TVAYFYDPDVGNFHYGTG----HPMKPHRLSLTHSLVLHYGLYKKMIVFKPYQASQHDMCRFHSE 64

  Fly   903 AHAMLFGSNQCQLSRPKLENTLSASFVRLSCGGLGVDLDT-----TWNEHHTATAARMAA---GC 959
            .:.     :..|...|   |.:......|:...:|.|...     .:...:|..:.:.|.   ..
Frog    65 DYI-----DFLQRVSP---NNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQGATQLNNK 121

  Fly   960 VIDLALKTAKGDLRNGFAVVRPPGHHAEANLAMGFCFFNSIAIAAKLLRQRMPEVRRILIVDWDV 1024
            :.|:|:..|.|            .|||:...|.|||:.|.|.|....|.:..|   |:|.||.|:
Frog   122 ICDIAINWAGG------------LHHAKKFEASGFCYVNDIVIGILELLKYHP---RVLYVDIDI 171

  Fly  1025 HHGNGTQQAFYQSPDILYLSIHRHDDGN-FFPGTGGPTECGSGAGLGFNVNISWSGALNPPLGDA 1088
            |||:|.|:|||.:..::.:|.|::  || ||||||...|.|:.:|..:.:|:    .|...:.|.
Frog   172 HHGDGVQEAFYLTDRVMTVSFHKY--GNYFFPGTGDMYEVGAESGRYYCLNV----PLRDGIDDQ 230

  Fly  1089 EYIAAFRTVVMPIARSFNPDIVLVSSGFDAATGHPAPLGGYHVSPACFGFMTR---ELLQLANGK 1150
            .|...|:.|:..:...:.|..:::..|.|:       ||...:  .||....|   |.:|.....
Frog   231 SYRHLFQPVIKQVIDFYQPTCIVLQCGADS-------LGCDRL--GCFNLSIRGHGECVQYVKSF 286

  Fly  1151 VV--LALEGG------------YDLAAICDSA-------QECVRALLGD-PAAPIAKAELERPPC 1193
            .:  |.|.||            |:.:.:.|..       .|.......| ...|.....:|.
Frog   287 NIPLLVLGGGGYTVRNVARCWTYETSLLVDETISEELPYSEYFEYFAPDFTLHPDVSTRIEN--- 348

  Fly  1194 QNAINTLQKTIAIQQTHWPCVRMLEHTVGLSALETLKVEHDESETINAMAGLSMQSMHRTLSRDD 1258
            ||:...|.:   |:||.:..::||.|...:..       ||....|              ||.:.
Frog   349 QNSRQYLDQ---IRQTIFENLKMLNHAPSVQI-------HDVPSDI--------------LSYER 389

  Fly  1259 SEEPMDQDE 1267
            ::|| |.:|
Frog   390 TDEP-DPEE 397

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HDAC4	NP_001259507.1	iSH2_PI3K_IA_R	43..>87	CDD:304922
HDAC4	NP_001259507.1	HDAC_classIIa	837..1211	CDD:212544	97/406 (24%)
hdac3	NP_001016883.1	HDAC3	3..383	CDD:212529	102/433 (24%)
		Histone deacetylase	3..316		86/353 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	386..428		5/13 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910