DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment HDAC4 and HDAC7

DIOPT Version :9

Sequence 1:NP_001259507.1 Gene:HDAC4 / 32278 FlyBaseID:FBgn0041210 Length:1269 Species:Drosophila melanogaster
Sequence 2:XP_011536780.1 Gene:HDAC7 / 51564 HGNCID:14067 Length:1035 Species:Homo sapiens


Alignment Length:1195 Identity:415/1195 - (34%)
Similarity:557/1195 - (46%) Gaps:327/1195 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   131 QHRQQLH--------QQQQQHQQQQ--------QQQQHQQQQQQQQARGRDGMKLKQNCSANASP 179
            |..|:||        |||:..:..:        :.|...|:|:.:|...:|    |...||.||.
Human   106 QRPQRLHHHLFLAGLQQQRSVEPMRLSMDTPMPELQVGPQEQELRQLLHKD----KSKRSAVASS 166

  Fly   180 EVKQILNCFILSRKSQAAASNGTTTTS---PYR------NRGVVKSSSGESLPAGTVTSAHPYKI 235
            .|||.|...|| :|.|||........|   |||      ..|..:|.....||  .|.|     :
Human   167 VVKQKLAEVIL-KKQQAALERTVHPNSPGIPYRTLEPLETEGATRSMLSSFLP--PVPS-----L 223

  Fly   236 PQPPPSLLKYESDFPLRKTASEPNL-LKIRLKQSVIERK----ARIGGPAGARRH--ERLLQAAQ 293
            |..||      ..||||||.||||| |:.:.|:|:..||    .:...|...||.  |.|..:: 
Human   224 PSDPP------EHFPLRKTVSEPNLKLRYKPKKSLERRKNPLLRKESAPPSLRRRPAETLGDSS- 281

  Fly   294 RRQQKNSVLTNCNSTPDSGPNSPPSAAALAVGVVGSRGSPTSAPIQEENEEGSQYQPGQRSSIND 358
                     .:.:|||.||.:||..          |...|.  ||.     ||:...|||..:.:
Human   282 ---------PSSSSTPASGCSSPND----------SEHGPN--PIL-----GSEALLGQRLRLQE 320

  Fly   359 LPL--FSSPS---LPNISLGRPHLPNSAQAHAQVNAQVAAQAQAQAQAQAQAHAMFAALAAAQGG 418
            ..:  |:.|:   ||.|:||.|                   |.|:|.:..:.|   ..|......
Human   321 TSVAPFALPTVSLLPAITLGLP-------------------APARADSDRRTH---PTLGPRGPI 363

  Fly   419 CGQPGYYNPLGMAFVGRQPAPLAMIPATGIAPQQPSPVVRSASATSTSSSQASL--VGDVAPPQA 481
            .|.|  :.||.:.. |.:|      .|.|..|.:..|::    ....|.|.|.|  |..:.|...
Human   364 LGSP--HTPLFLPH-GLEP------EAGGTLPSRLQPIL----LLDPSGSHAPLLTVPGLGPLPF 415

  Fly   482 HAASTILPSSSSYMQQLGSVAGSGVNLHAAAVAAAAAAAAAAGSLPPTNSHGHGHGSHAHPHPHA 546
            |.|.:::.:.        .::|||:                                        
Human   416 HFAQSLMTTE--------RLSGSGL---------------------------------------- 432

  Fly   547 HGHGHGHGHGIYAGHQHNVPITDAQVAQVHLHKQGHRPLGRTQSAPLPLGHPMLT-----GAVQ- 605
                                               |.||.||:|.|||   |..|     |.:| 
Human   433 -----------------------------------HWPLSRTRSEPLP---PSATAPPPPGPMQP 459

  Fly   606 -LNVVQTHYENSEAERQAYEHQVVNQKVRQTVLTRSGAAAAAAAAAGVSVVREAQLKEEDDDSAA 669
             |..::||.            ||:.:..:.:...|            :..:..|:..|.|.....
Human   460 RLEQLKTHV------------QVIKRSAKPSEKPR------------LRQIPSAEDLETDGGGPG 500

  Fly   670 EVMD--LTDKKKPPKTVLTSTIATSTSQNLPEALAAAAAAAAYRAPHNASSNSASATKSGIKLRD 732
            :|:|  |..::              .....|||...|..                          
Human   501 QVVDDGLEHRE--------------LGHGQPEARGPAPL-------------------------- 525

  Fly   733 QEYLQQQREQLLLLQQEEELAKSLMRPLSRTLSSPLVPLGPHGLSQIPDTGQQPAPIATSSSADH 797
                 ||..|:||.:| :.||..|  |...|..:.|:||.        ..|.:|...|.||.|  
Human   526 -----QQHPQVLLWEQ-QRLAGRL--PRGSTGDTVLLPLA--------QGGHRPLSRAQSSPA-- 572

  Fly   798 IPPVNLSLPHRQHRQLMSTLYASQLRNHQPSASGSPPHKVTTGLAYDPLMLKHSCICGDNAQHPE 862
             .|.:||.|..          |||.|....|.:.:.....||||.||.:||||.|.||||::|||
Human   573 -APASLSAPEP----------ASQARVLSSSETPARTLPFTTGLIYDSVMLKHQCSCGDNSRHPE 626

  Fly   863 HSGRLQSVWARLNETDLVKRCDRLRARKATQEELQTVHTEAHAMLFGSNQCQLSRPKLENTLSAS 927
            |:||:||:|:||.|..|..:|:.||.|||:.||||:||:|.|.:|:|:|  .|||.||:|...|.
Human   627 HAGRIQSIWSRLQERGLRSQCECLRGRKASLEELQSVHSERHVLLYGTN--PLSRLKLDNGKLAG 689

  Fly   928 ------FVRLSCGGLGVDLDTTWNEHHTATAARMAAGCVIDLALKTAKGDLRNGFAVVRPPGHHA 986
                  ||.|.|||:|||.||.|||.|::.|||.|||.|.|||.|.|..:|:|||||||||||||
Human   690 LLAQRMFVMLPCGGVGVDTDTIWNELHSSNAARWAAGSVTDLAFKVASRELKNGFAVVRPPGHHA 754

  Fly   987 EANLAMGFCFFNSIAIAAKLLRQRMPEVRRILIVDWDVHHGNGTQQAFYQSPDILYLSIHRHDDG 1051
            :.:.|||||||||:|||.:.|:|: .:..:||||||||||||||||.|||.|.:||:|:||||||
Human   755 DHSTAMGFCFFNSVAIACRQLQQQ-SKASKILIVDWDVHHGNGTQQTFYQDPSVLYISLHRHDDG 818

  Fly  1052 NFFPGTGGPTECGSGAGLGFNVNISWSGALNPPLGDAEYIAAFRTVVMPIARSFNPDIVLVSSGF 1116
            |||||:|...|.|:|:|.|||||::|:|.|:||:||.||:||||.|||||||.|:||:||||:||
Human   819 NFFPGSGAVDEVGAGSGEGFNVNVAWAGGLDPPMGDPEYLAAFRIVVMPIAREFSPDLVLVSAGF 883

  Fly  1117 DAATGHPAPLGGYHVSPACFGFMTRELLQLANGKVVLALEGGYDLAAICDSAQECVRALLGDPAA 1181
            |||.||||||||||||..|||:||::|:.||.|.||||||||:||.||||:::.||.||||:...
Human   884 DAAEGHPAPLGGYHVSAKCFGYMTQQLMNLAGGAVVLALEGGHDLTAICDASEACVAALLGNRVD 948

  Fly  1182 PIAKAELERPPCQNAINTLQKTIAIQQTHWPCVRMLEHTVGLSALETLKVEHDESETINAMAGLS 1246
            |:::...::.|..|||.:|:..|.:...:|.|::.|..............:.:|.|.:.|:|.||
Human   949 PLSEEGWKQKPNLNAIRSLEAVIRVHSKYWGCMQRLASCPDSWVPRVPGADKEEVEAVTALASLS 1013

  Fly  1247 MQSMHRTLSRD-------DSEEPMD 1264
            :    ..|:.|       :.||||:
Human  1014 V----GILAEDRPSEQLVEEEEPMN 1034

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HDAC4NP_001259507.1 iSH2_PI3K_IA_R 43..>87 CDD:304922
HDAC_classIIa 837..1211 CDD:212544 231/379 (61%)
HDAC7XP_011536780.1 HDAC7 601..978 CDD:212532 231/379 (61%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 448 1.000 Domainoid score I516
eggNOG 1 0.900 - - E1_COG0123
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D119187at33208
OrthoFinder 1 1.000 - - FOG0001001
OrthoInspector 1 1.000 - - otm41987
orthoMCL 1 0.900 - - OOG6_100220
Panther 1 1.100 - - O PTHR48252
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X933
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1110.780

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