Protein Alignment HDAC4 and HDAC3

DIOPT Version :10

• Sequence 1: NP_001259507.1
• Gene: HDAC4 / 32278
• FlyBaseID: FBgn0041210
• Length: 1269
• Species: Drosophila melanogaster
• Sequence 2: NP_651978.2
• Gene: HDAC3 / 44446
• FlyBaseID: FBgn0025825
• Length: 438
• Species: Drosophila melanogaster
• Alignment Length: 457
• Identity: 105/457 - (22%)
• Similarity: 177/457 - (38%)
• Gaps: 90/457 - (19%)

  Fly   858 AQHPEHSGRLQSVWARLNETDLVKRCDRLRARKATQEELQTVHTE---AHAMLFGSNQCQLSRPK 919
            |.||....||....:.:....|.|:....|..||:.:::...|::   |:.........|.:...
  Fly    21 AGHPMKPQRLAVTHSLVMNYGLHKKMKIYRPYKASAQDMLRFHSDEYIAYLQQVTPQNIQCNSVA 85

  Fly   920 LENTLSASFVRLSC---GGL--------GVDLD--TTWNEHHTATAARMAAGCVIDLALKTAKGD 971
            ....|:...|...|   .||        |..|:  ...|.:|:......:.|.
  Fly    86 YTKYLAHFSVGEDCPVFDGLFDFCAMYTGASLEGAQKLNHNHSDICINWSGGL------------ 138

  Fly   972 LRNGFAVVRPPGHHAEANLAMGFCFFNSIAIAAKLLRQRMPEVRRILIVDWDVHHGNGTQQAFYQ 1036
                        |||:...|.|||:.|.|.|....|.:..|   |:|.:|.|||||:|.|:|||.
  Fly   139 ------------HHAKKFEASGFCYVNDIVIGILELLKYHP---RVLYIDIDVHHGDGVQEAFYL 188

  Fly  1037 SPDILYLSIHRHDDGN-FFPGTGGPTECGSGAGLGFNVNISWSGALNPPLGDAEYIAAFRTVVMP 1100
            :..::..|.|::  || ||||||...|.|:.:|..::||:    .|...:.|..|...|:.::..
  Fly   189 TDRVMTASFHKY--GNYFFPGTGDMYEIGAESGRYYSVNV----PLKEGIDDQSYFQVFKPIISA 247

  Fly  1101 IARSFNPDIVLVSSGFDAATGHPAPLGGYHVSPACFGFMTR------ELLQLANGKVVLALEGGY 1159
            |...:.|..:::..|.|:..|.  .||       ||...|:      :.::..|...::...|||
  Fly   248 IMDFYRPTAIVLQCGADSLAGD--RLG-------CFSLSTKGHGECVKFVKELNVPTLVVGGGGY 303

  Fly  1160 DL--AAICDSAQECVRALLGD-------PA-------APIAKAELERPPCQNAINTLQKTIAIQQ 1208
            .|  .|.|.:.:   .:||.|       ||       ||......|....|:..|:.|....|.:
  Fly   304 TLRNVARCWTHE---TSLLVDQDIENDLPATEYYDFFAPDFTLHPEINSRQDNANSKQYLELIVK 365

  Fly  1209 THWPCVRMLEHTVGLSALET------LKVEHDESETINAMAGLSMQSMHRTLSRDDSEEPMDQDE 1267
            ..:..::|.:|:..:..::|      .::..:..|..:....:|:....:.:...:.....|||:
  Fly   366 HVYENLKMCQHSPSVQMVQTPPDVDLEELRSNREEASDPDVRISVADEDKLVDAKNEFYDGDQDQ 430

  Fly  1268 TK 1269
            .|
  Fly   431 DK 432

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HDAC4	NP_001259507.1	ClassIIa_HDAC_Gln-rich-N	43..>87	CDD:421006
		HDAC_classIIa	837..1211	CDD:212544	96/391 (25%)
HDAC3	NP_651978.2	HDAC3	4..388	CDD:212529	99/411 (24%)