DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HDAC4 and HDAC3

DIOPT Version :9

Sequence 1:	NP_001259507.1	Gene:	HDAC4 / 32278	FlyBaseID:	FBgn0041210	Length:	1269	Species:	Drosophila melanogaster
Sequence 2:	NP_651978.2	Gene:	HDAC3 / 44446	FlyBaseID:	FBgn0025825	Length:	438	Species:	Drosophila melanogaster

Alignment Length:	457	Identity:	105/457 - (22%)
Similarity:	177/457 - (38%)	Gaps:	90/457 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   858 AQHPEHSGRLQSVWARLNETDLVKRCDRLRARKATQEELQTVHTE---AHAMLFGSNQCQLSRPK 919
            |.||....||....:.:....|.|:....|..||:.:::...|::   |:.........|.:...
  Fly    21 AGHPMKPQRLAVTHSLVMNYGLHKKMKIYRPYKASAQDMLRFHSDEYIAYLQQVTPQNIQCNSVA 85

  Fly   920 LENTLSASFVRLSC---GGL--------GVDLD--TTWNEHHTATAARMAAGCVIDLALKTAKGD 971
            ....|:...|...|   .||        |..|:  ...|.:|:......:.|.
  Fly    86 YTKYLAHFSVGEDCPVFDGLFDFCAMYTGASLEGAQKLNHNHSDICINWSGGL------------ 138

  Fly   972 LRNGFAVVRPPGHHAEANLAMGFCFFNSIAIAAKLLRQRMPEVRRILIVDWDVHHGNGTQQAFYQ 1036
                        |||:...|.|||:.|.|.|....|.:..|   |:|.:|.|||||:|.|:|||.
  Fly   139 ------------HHAKKFEASGFCYVNDIVIGILELLKYHP---RVLYIDIDVHHGDGVQEAFYL 188

  Fly  1037 SPDILYLSIHRHDDGN-FFPGTGGPTECGSGAGLGFNVNISWSGALNPPLGDAEYIAAFRTVVMP 1100
            :..::..|.|::  || ||||||...|.|:.:|..::||:    .|...:.|..|...|:.::..
  Fly   189 TDRVMTASFHKY--GNYFFPGTGDMYEIGAESGRYYSVNV----PLKEGIDDQSYFQVFKPIISA 247

  Fly  1101 IARSFNPDIVLVSSGFDAATGHPAPLGGYHVSPACFGFMTR------ELLQLANGKVVLALEGGY 1159
            |...:.|..:::..|.|:..|.  .||       ||...|:      :.::..|...::...|||
  Fly   248 IMDFYRPTAIVLQCGADSLAGD--RLG-------CFSLSTKGHGECVKFVKELNVPTLVVGGGGY 303

  Fly  1160 DL--AAICDSAQECVRALLGD-------PA-------APIAKAELERPPCQNAINTLQKTIAIQQ 1208
            .|  .|.|.:.:   .:||.|       ||       ||......|....|:..|:.|....|.:
  Fly   304 TLRNVARCWTHE---TSLLVDQDIENDLPATEYYDFFAPDFTLHPEINSRQDNANSKQYLELIVK 365

  Fly  1209 THWPCVRMLEHTVGLSALET------LKVEHDESETINAMAGLSMQSMHRTLSRDDSEEPMDQDE 1267
            ..:..::|.:|:..:..::|      .::..:..|..:....:|:....:.:...:.....|||:
  Fly   366 HVYENLKMCQHSPSVQMVQTPPDVDLEELRSNREEASDPDVRISVADEDKLVDAKNEFYDGDQDQ 430

  Fly  1268 TK 1269
            .|
  Fly   431 DK 432

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HDAC4	NP_001259507.1	iSH2_PI3K_IA_R	43..>87	CDD:304922
HDAC4	NP_001259507.1	HDAC_classIIa	837..1211	CDD:212544	96/391 (25%)
HDAC3	NP_651978.2	HDAC3	4..388	CDD:212529	99/411 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45458015
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0123
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48252
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840