DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HDAC4 and Sirt6

DIOPT Version :9

Sequence 1:	NP_001259507.1	Gene:	HDAC4 / 32278	FlyBaseID:	FBgn0041210	Length:	1269	Species:	Drosophila melanogaster
Sequence 2:	NP_649990.2	Gene:	Sirt6 / 41254	FlyBaseID:	FBgn0037802	Length:	325	Species:	Drosophila melanogaster

Alignment Length:	371	Identity:	66/371 - (17%)
Similarity:	119/371 - (32%)	Gaps:	110/371 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   694 SQNLPEALAAAAAAAAYRAPHNASSNSASATKSGIKLRDQEYLQQQREQLLLLQQEEELAKSLMR 758
            |.|..:.|:|........||.:..|:...|.|                    .|:..||.|....
  Fly     2 SCNYADGLSAYDNKGILGAPESFDSDEVVAEK--------------------CQELAELIKKSGH 46

  Fly   759 PLSRT----LSSPLVP--LGPHGLSQIPDTGQQPAPIATSSSADHIPPVNLSL----PHRQHRQL 813
            .:..|    .:|..:|  .||.|:..:.:.|::             |..|:|.    |.:.|..:
  Fly    47 VVLHTGAGISTSAGIPDFRGPKGVWTLEEKGEK-------------PDFNVSFDEARPTKTHMAI 98

  Fly   814 MSTLYASQLRNHQPSASGSPPHKVTTGLAYDPLMLKHSCICGDNAQHPEHSGRLQSVWARLNETD 878
            ::.:           .||...:.::..:  |.|.||              ||..:...:.|:...
  Fly    99 IALI-----------ESGYVQYVISQNI--DGLHLK--------------SGLDRKYLSELHGNI 136

  Fly   879 LVKRCDRLRARKATQEELQTVHTEAHAMLFGSNQCQLSRPKLENTLSASFVRLSC-GGLGVDLDT 942
            .:::|.:.|.:..:...::||..::......|:.....|              || .|:..|...
  Fly   137 YIEQCKKCRRQFVSPSAVETVGQKSLQRACKSSMDSKGR--------------SCRSGILYDNVL 187

  Fly   943 TWNE------------HHTATAARMAAGCVI------DLALKTAKGDLRNGFAVVRPPGHHAEAN 989
            .|..            |.|.....:|.|..:      ||.||..|...:.....::|..|..:||
  Fly   188 DWEHDLPENDLEMGVMHSTVADLNIALGTTLQIVPSGDLPLKNLKCGGKFVICNLQPTKHDKKAN 252

  Fly   990 LAMGFCFFNSIAIAAKLLRQRMPE-------VRRILIVDWDVHHGN 1028
            |.:.......::...|||...:||       .::...::|.:...|
  Fly   253 LIISSYVDVVLSKVCKLLGVEIPEYSEASDPTKQSKPMEWTIPTSN 298

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HDAC4	NP_001259507.1	iSH2_PI3K_IA_R	43..>87	CDD:304922
HDAC4	NP_001259507.1	HDAC_classIIa	837..1211	CDD:212544	39/218 (18%)
Sirt6	NP_649990.2	SIRT7	45..258	CDD:238701	46/266 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48252
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100