DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HDAC4 and hdac3

DIOPT Version :9

Sequence 1:	NP_001259507.1	Gene:	HDAC4 / 32278	FlyBaseID:	FBgn0041210	Length:	1269	Species:	Drosophila melanogaster
Sequence 2:	NP_957284.1	Gene:	hdac3 / 393965	ZFINID:	ZDB-GENE-040426-847	Length:	428	Species:	Danio rerio

Alignment Length:	425	Identity:	102/425 - (24%)
Similarity:	166/425 - (39%)	Gaps:	102/425 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   839 TGLAYDPLMLKHSCICGD---NAQHPEHSGRLQSVWARLNETDLVKRCDRLRARKATQEELQTVH 900
            |...|||.:       |:   .|.||....||....:.:....|.|:....:..||:|.::...|
Zfish     5 TAYFYDPDV-------GNFHYGAGHPMKPHRLSLTHSLVLHYGLYKKMMVFKPYKASQHDMCRFH 62

  Fly   901 TEAHAMLFGSNQCQLSRPKLENTLSASFVRLSCGG---------------LGVDLDTTWNEHHTA 950
            :|.:.     :..|...|......:.|....:.||               .|..|......:|.
Zfish    63 SEDYI-----DFLQKVSPNNMQGFTKSLNTFNVGGDCPVFPGLFEFCSRYTGASLQGATQLNHK- 121

  Fly   951 TAARMAAGCVIDLALKTAKGDLRNGFAVVRPPGHHAEANLAMGFCFFNSIAIAAKLLRQRMPEVR 1015
                     :.|:|:..|.|            .|||:...|.|||:.|.|.|:...|.:..|
Zfish   122 ---------ICDIAINWAGG------------LHHAKKFEASGFCYVNDIVISILELLKYHP--- 162

  Fly  1016 RILIVDWDVHHGNGTQQAFYQSPDILYLSIHRHDDGN-FFPGTGGPTECGSGAGLGFNVNISWSG 1079
            |:|.:|.|:|||:|.|:|||.:..::.:|.|::  || ||||||...|.|:.:|..:.:|:
Zfish   163 RVLYIDIDIHHGDGVQEAFYLTDRVMTVSFHKY--GNYFFPGTGDMYEVGAESGRYYCLNV---- 221

  Fly  1080 ALNPPLGDAEYIAAFRTVVMPIARSFNPDIVLVSSGFDAATGHPAPLGGYHVSPACFGFMTR--- 1141
            .|...:.|..|...|:.|:..:...:.|..:::..|.|:       ||...:  .||....|
Zfish   222 PLRDGIDDQSYRQLFQPVIKQVVDFYQPTCIVLQCGADS-------LGCDRL--GCFNLSIRGHG 277

  Fly  1142 ELLQLANG-KVVLAL--EGGYDL--AAICDSAQE--CVRALLGDPAA---------------PIA 1184
            |.::...| |:.|.:  .|||.:  .|.|.:.:.  .|...:.|...               |..
Zfish   278 ECVEFVKGFKIPLLVLGGGGYTVRNVARCWTFETSLLVEESISDELPYSEYFEYFAPDFTLHPDV 342

  Fly  1185 KAELERPPCQNAINTLQKTIAIQQTHWPCVRMLEH 1219
            ...:|.   ||:...|::   |:||.:..::||.|
Zfish   343 STRIEN---QNSRQYLEQ---IRQTVFENLKMLNH 371

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HDAC4	NP_001259507.1	iSH2_PI3K_IA_R	43..>87	CDD:304922
HDAC4	NP_001259507.1	HDAC_classIIa	837..1211	CDD:212544	99/415 (24%)
hdac3	NP_957284.1	PTZ00063	1..394	CDD:240251	102/425 (24%)
		HDAC3	3..383	CDD:212529	102/425 (24%)
		Histone deacetylase	3..316		89/362 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	381..428
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0123
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810