DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HDAC4 and hdac9b

DIOPT Version :9

Sequence 1:	NP_001259507.1	Gene:	HDAC4 / 32278	FlyBaseID:	FBgn0041210	Length:	1269	Species:	Drosophila melanogaster
Sequence 2:	XP_005158021.1	Gene:	hdac9b / 393789	ZFINID:	ZDB-GENE-040109-7	Length:	609	Species:	Danio rerio

Alignment Length:	718	Identity:	165/718 - (22%)
Similarity:	279/718 - (38%)	Gaps:	203/718 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 IDQQIMELKKSQELQKQRLINSFQEQSKQMELEHKLQLEHKYQKQPTNKRFSLELIVIIQFAVNS 107
            :.|:::.::|.|::|||.||..||:|.:.:..:|:.|::...:.|
Zfish    76 LQQELLLIQKQQQIQKQLLITEFQKQHENLVRQHQAQIQEHLKLQ-------------------- 120

  Fly   108 HGAFQELRNESMVTAAAAAVAQEQHRQQLHQQQQQHQQQQQQ--QQHQQQQQQQQARGRDGMKLK 170
                |||.            ..:|.::||.::::...|.|::  ::|:::||....|.|:    :
Zfish   121 ----QELH------------VMKQQQEQLEKERKLELQSQERELERHRREQQVLVLRNRE----R 165

  Fly   171 QNCSANASPEVKQILNCFILSRKSQAAASNG-----TTTTSPYRNRGVVKSSSGESLPAGTVTSA 230
            ...||.||.||||.|..|:||:.::....||     |.::..:.......|....|.|.|..:|:
Zfish   166 TRESAVASNEVKQKLQEFLLSKSTKDITLNGIPQKITQSSKLWYTASHHTSLEQSSPPLGGASSS 230

  Fly   231 HPYKIPQPPPSLLKYESDFPLRKTASEPNL-LKIRLKQSVIERKARIGGPAGARRHERLLQAAQR 294
            ....:|.|.    .|..|||||||.||||| ::.||||.|.||::   .|...|:...::...::
Zfish   231 CKISLPSPQ----DYRDDFPLRKTVSEPNLKVRSRLKQKVAERRS---SPLLRRKEGNIMTPFKK 288

  Fly   295 RQQKNSVLTNCNSTPDSGPNSPPSAAALAVGVVGSRGSPTSAPIQEENEEGSQYQP--GQRSSIN 357
            |..:....|..:|.|.|||:||..|.:    .:|:...|:|.|:....|.......  |..||::
Zfish   289 RALELLESTASSSAPGSGPSSPNGACS----ALGAENGPSSLPVTTRTERWPSQSRLLGPESSVS 349

  Fly   358 DLPLFSSPSLPNISLGRPHLPNSAQAHAQVNAQVAAQAQAQAQAQAQAHAMFAALAAAQGGCGQP 422
            .|.|::||||||||||      .:.|.:.::|.:..|         :.|....|::|.
Zfish   350 MLNLYTSPSLPNISLG------FSAASSPISAALGLQ---------EKHVDNGAVSAV------- 392

  Fly   423 GYYNPLGMAFVGRQPAPLAMIPATGIAPQQPSPVVRSASATSTSSSQASLVGDVAPPQAHAASTI 487
                                  ..|:..|...||..|...|..|||..:|:..:...:......|
Zfish   393 ----------------------IQGLPTQLLGPVPLSVMETKVSSSHQALLQHLLQKEQLRHQKI 435

  Fly   488 LPSSSSYMQQLGSVAGSGVNLHAAAVAAAAAAAAAAGSLPPTNSHGHGHGSHAHPHPHAHGHGHG 552
            |.|..|                                  |.:.          |.|.|
Zfish   436 LSSGQS----------------------------------PVHP----------PSPLA------ 450

  Fly   553 HGHGIYAGHQHNVPITDAQVAQVHLHKQGHRPLGRTQSAPLPLGHPMLTGAVQLNVVQTHYENSE 617
                    ...|.|      :........||||.||||||||     .:...||.:.|.|....|
Zfish   451 --------MMENSP------SSTRPKLPRHRPLNRTQSAPLP-----QSTLAQLVIQQQHQSFLE 496

  Fly   618 AERQAYEHQV-VNQKVRQTVLTRSGAAAAAAAAAGVSVVRE--AQLKEEDDDSAAEVMD--LTDK 677
            .::| |:.|| :|:     :|::|           :..:|:  ..|:|.:::...:..:  :.::
Zfish   497 KQKQ-YQQQVHINK-----MLSKS-----------IEQLRQPNVHLQESEEEEGEDCQEHAMQEE 544

  Fly   678 KKPPKTVLTSTIATSTSQNLPEALAAAAAAAAYRAPHNASSNSASATKSGIKLRDQEYLQQQREQ 742
            ..|...|:......:||::....|.:.......:....||.:...|.:|       .|:.|.:.:
Zfish   545 SSPSGGVIRKHSPQNTSRSPTIPLDSHPGVIRVKEEPGASDDETMANQS-------SYIHQVKGR 602

  Fly   743 LLL 745
            :::
Zfish   603 MVI 605

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HDAC4	NP_001259507.1	iSH2_PI3K_IA_R	43..>87	CDD:304922	13/43 (30%)
HDAC4	NP_001259507.1	HDAC_classIIa	837..1211	CDD:212544
hdac9b	XP_005158021.1	ClassIIa_HDAC9_Gln-rich-N	68..157	CDD:197399	24/116 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	133	1.000	Domainoid score	I5010
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100220
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810