DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HDAC4 and HDAC1

DIOPT Version :9

Sequence 1:	NP_001259507.1	Gene:	HDAC4 / 32278	FlyBaseID:	FBgn0041210	Length:	1269	Species:	Drosophila melanogaster
Sequence 2:	NP_647918.2	Gene:	HDAC1 / 38565	FlyBaseID:	FBgn0015805	Length:	521	Species:	Drosophila melanogaster

Alignment Length:	445	Identity:	106/445 - (23%)
Similarity:	179/445 - (40%)	Gaps:	106/445 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   860 HPEHSGRLQSVWARLNETDLVKRCDRLRARKATQEELQTVHTEAHAMLFGSNQCQLSRPKLENTL 924
            ||....|::.....|....|.::.:..|..|||.:|:...|::.:.....|     .||...:..
  Fly    26 HPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATADEMTKFHSDEYVRFLRS-----IRPDNMSEY 85

  Fly   925 SASFVRLSCGGLGVDLDTTWNEHHTATAARMAAGCVIDLALKTAK----------GDLRNGFAVV 979
            :....|.:.|......|..:.      ..:::||..:..|:|..|          |.|
  Fly    86 NKQMQRFNVGEDCPVFDGLYE------FCQLSAGGSVAAAVKLNKQASEICINWGGGL------- 137

  Fly   980 RPPGHHAEANLAMGFCFFNSIAIA-AKLLRQRMPEVRRILIVDWDVHHGNGTQQAFYQSPDILYL 1043
                |||:.:.|.|||:.|.|.:. .:||:..    :|:|.:|.|||||:|.::|||.:..::.:
  Fly   138 ----HHAKKSEASGFCYVNDIVLGILELLKYH----QRVLYIDIDVHHGDGVEEAFYTTDRVMTV 194

  Fly  1044 SIHRHDDGNFFPGTGGPTECGSGAGLGFNVNISWSGALNPPLGDAEYIAAFRTVVMPIARSFNPD 1108
            |.|::  |.:|||||...:.|:|.|..:.|||    .|...:.|..|.:.|..::..:..:|.|.
  Fly   195 SFHKY--GEYFPGTGDLRDIGAGKGKYYAVNI----PLRDGMDDDAYESIFVPIISKVMETFQPA 253

  Fly  1109 IVLVSSGFDAATGHPAPLGGYHVSPACFGFMTR------ELLQLANGKVVLALEGGYDLAAI--C 1165
            .|::..|.|:.||.  .||       ||....:      |.::..|...::...|||.:..:  |
  Fly   254 AVVLQCGADSLTGD--RLG-------CFNLTVKGHGKCVEFVKKYNLPFLMVGGGGYTIRNVSRC 309

  Fly  1166 DSAQECVRALLGDPAAPIAKA--------------ELERPPC----QNAINTLQKTIAIQQTHWP 1212
            .:.:..| ||    |..||..              :|...|.    ||....|:|   |:...:.
  Fly   310 WTYETSV-AL----AVEIANELPYNDYFEYFGPDFKLHISPSNMTNQNTSEYLEK---IKNRLFE 366

  Fly  1213 CVRMLEHTVGLSALETLKVEHDESETINAMAGLSMQSMHRTLSRDDSEEPMDQDE 1267
            .:|||.|..|      ::::....:.||              ...|.|:.:|:|:
  Fly   367 NLRMLPHAPG------VQIQAIPEDAIN--------------DESDDEDKVDKDD 401

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HDAC4	NP_001259507.1	iSH2_PI3K_IA_R	43..>87	CDD:304922
HDAC4	NP_001259507.1	HDAC_classIIa	837..1211	CDD:212544	95/387 (25%)
HDAC1	NP_647918.2	Arginase_HDAC	5..372	CDD:388375	97/394 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45458014
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0123
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48252
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840