Protein Alignment HDAC4 and Hdac8

DIOPT Version :10

• Sequence 1: NP_001259507.1
• Gene: HDAC4 / 32278
• FlyBaseID: FBgn0041210
• Length: 1269
• Species: Drosophila melanogaster
• Sequence 2: XP_017457598.1
• Gene: Hdac8 / 363481
• RGDID: 1562895
• Length: 393
• Species: Rattus norvegicus
• Alignment Length: 360
• Identity: 97/360 - (26%)
• Similarity: 163/360 - (45%)
• Gaps: 53/360 - (14%)

  Fly   826 QPSASGSPPHKVTTGLAYDPLMLKHSCICGDNAQHPEHSGRLQSVWARLNETDLVKRCDRLRARK 890
            :|:.||   |.:.....|.|   ::..||....:.|:.:..:.|:   :....|.|:...::.:.
  Rat     6 EPANSG---HSLPPVYIYSP---EYVSICDSLVKVPKRASMVHSL---IEAYALHKQMRIVKPKV 61

  Fly   891 ATQEELQTVHTEAHAMLFGSNQCQLSRPKLE----NTLSASFVRLSCGGLGVDLDTTWNEHHTAT 951
            |:.||:.|.||:|:..       .|.:...|    :..|..:      |||.|...|......|.
  Rat    62 ASMEEMATFHTDAYLQ-------HLQKVSQEGDEDHPDSIEY------GLGYDCPATEGIFDYAA 113

  Fly   952 A----ARMAAGCVIDLALKTAKGDLRNGFAVVRPPGHHAEANLAMGFCFFNSIAIAAKLLRQRMP 1012
            |    ...||.|:||...|.|. :...|:       |||:.:.|.|||:.|...:....||::..
  Rat   114 AIGGGTITAAQCLIDGKCKVAI-NWSGGW-------HHAKKDEASGFCYLNDAVLGILRLRRKFD 170

  Fly  1013 EVRRILIVDWDVHHGNGTQQAFYQSPDILYLSIHRHDDGNFFPGTGGPTECGSGAGLGFNVNISW 1077
               |||.||.|:|||:|.:.||..:..::.:|:|:...| ||||||..::.|.|.|..::||:
  Rat   171 ---RILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPG-FFPGTGDMSDVGLGKGRYYSVNV-- 229

  Fly  1078 SGALNPPLGDAEYIAAFRTVVMPIARSFNPDIVLVSSGFDAATGHPAPLGGYHVSPACFGFMTRE 1142
              .:...:.|.:|.....:|:..:.::|||..|::..|.|...|.  |:..::::|...|...:.
  Rat   230 --PIQDGIQDEKYYHICESVLKEVYQAFNPKAVVLQLGADTIAGD--PMCSFNMTPVGIGKCLKY 290

  Fly  1143 LLQLANGKVVLALEGGYDLAAICDSAQECVRALLG 1177
            :||.....::|. .|||:||    :...|...|.|
  Rat   291 VLQWQLATLILG-GGGYNLA----NTARCWTYLTG 320

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HDAC4	NP_001259507.1	ClassIIa_HDAC_Gln-rich-N	43..>87	CDD:421006
		HDAC_classIIa	837..1211	CDD:212544	93/349 (27%)
Hdac8	XP_017457598.1	HDAC8	16..335	CDD:212524	93/347 (27%)