DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HDAC4 and Hdac8

DIOPT Version :9

Sequence 1:	NP_001259507.1	Gene:	HDAC4 / 32278	FlyBaseID:	FBgn0041210	Length:	1269	Species:	Drosophila melanogaster
Sequence 2:	XP_017457598.1	Gene:	Hdac8 / 363481	RGDID:	1562895	Length:	393	Species:	Rattus norvegicus

Alignment Length:	362	Identity:	97/362 - (26%)
Similarity:	162/362 - (44%)	Gaps:	57/362 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   826 QPSASGSPPHKVTTGLAYDPLMLKHSCICGDNAQHPEHSGRLQSVWARLNETDLVKRCDRLRARK 890
            :|:.||   |.:.....|.|   ::..||....:.|:.:..:.|:   :....|.|:...::.:.
  Rat     6 EPANSG---HSLPPVYIYSP---EYVSICDSLVKVPKRASMVHSL---IEAYALHKQMRIVKPKV 61

  Fly   891 ATQEELQTVHTEAHAMLFGSNQCQLSRPKLE----NTLSASFVRLSCGGLGVDLDTTWNEHHTAT 951
            |:.||:.|.||:|:..       .|.:...|    :..|..:      |||.|...|......|.
  Rat    62 ASMEEMATFHTDAYLQ-------HLQKVSQEGDEDHPDSIEY------GLGYDCPATEGIFDYAA 113

  Fly   952 A----ARMAAGCVIDLALKTAKGDLRNGFAVVRPPG--HHAEANLAMGFCFFNSIAIAAKLLRQR 1010
            |    ...||.|:||...|.|          :...|  |||:.:.|.|||:.|...:....||::
  Rat   114 AIGGGTITAAQCLIDGKCKVA----------INWSGGWHHAKKDEASGFCYLNDAVLGILRLRRK 168

  Fly  1011 MPEVRRILIVDWDVHHGNGTQQAFYQSPDILYLSIHRHDDGNFFPGTGGPTECGSGAGLGFNVNI 1075
            ..   |||.||.|:|||:|.:.||..:..::.:|:|:...| ||||||..::.|.|.|..::||:
  Rat   169 FD---RILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPG-FFPGTGDMSDVGLGKGRYYSVNV 229

  Fly  1076 SWSGALNPPLGDAEYIAAFRTVVMPIARSFNPDIVLVSSGFDAATGHPAPLGGYHVSPACFGFMT 1140
                .:...:.|.:|.....:|:..:.::|||..|::..|.|...|.  |:..::::|...|...
  Rat   230 ----PIQDGIQDEKYYHICESVLKEVYQAFNPKAVVLQLGADTIAGD--PMCSFNMTPVGIGKCL 288

  Fly  1141 RELLQLANGKVVLALEGGYDLAAICDSAQECVRALLG 1177
            :.:||.....::|. .|||:||    :...|...|.|
  Rat   289 KYVLQWQLATLILG-GGGYNLA----NTARCWTYLTG 320

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HDAC4	NP_001259507.1	iSH2_PI3K_IA_R	43..>87	CDD:304922
HDAC4	NP_001259507.1	HDAC_classIIa	837..1211	CDD:212544	93/351 (26%)
Hdac8	XP_017457598.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0123
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810