DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HDAC4 and HDAC6

DIOPT Version :9

Sequence 1:	NP_001259507.1	Gene:	HDAC4 / 32278	FlyBaseID:	FBgn0041210	Length:	1269	Species:	Drosophila melanogaster
Sequence 2:	NP_001259569.1	Gene:	HDAC6 / 32461	FlyBaseID:	FBgn0026428	Length:	1179	Species:	Drosophila melanogaster

Alignment Length:	1160	Identity:	300/1160 - (25%)
Similarity:	445/1160 - (38%)	Gaps:	323/1160 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   189 ILSRKS--QA-------AASNGTTTTSPYRNRGVVKSSSGESLPAGTVTSAHPYKIPQPPPSLLK 244
            |::|:|  ||       |:.:.|.||......|...||||..  :|...:|.|.|..:|..:||:
  Fly     5 IVTRRSAQQAKIQTRAMASKSKTGTTGAATAAGGTGSSSGSI--SGGFNAADPRKSNKPNAALLE 67

  Fly   245 YESDFPLRKTASEPNLLKIR----------LKQSVIERKARIGGPAGA--------------RRH 285
                   .|..:..|:||.:          :.|:.:..|:.:..|...              :.|
  Fly    68 -------AKRRARNNMLKNQGCGSQESVTDIFQNAVNSKSLVRKPTALIYDESMSQHCCLWDKEH 125

  Fly   286 ----ERLLQAAQRRQQKNSVLTNCNSTPDSGPNSPPSAAALAVGVVGSRGSPTSAPIQEENEE-- 344
                ||..:..:|.::.| :...|...| |...:......|.......|...||....:|..|
  Fly   126 YECPERFTRVLERCRELN-LTERCLELP-SRSATKDEILRLHTEEHFERLKETSGIRDDERMEEL 188

  Fly   345 GSQYQPGQRSSINDLPLFSSPSLPNISLGRPHLPNSAQAHAQVNAQVAAQAQ-AQAQAQAQAHAM 408
            .|:|.          .::..||...:|     |..|......|:..||.:|| ..|..:...|
  Fly   189 SSRYD----------SIYIHPSTFELS-----LLASGSTIELVDHLVAGKAQNGMAIIRPPGH-- 236

  Fly   409 FAALAAAQGGCGQPGYYNPLGMAFVGRQPAPLAMIPATGIAPQQPSPVVRSASATSTSSSQASLV 473
            .|..|...|.|    ::|.:.:|                           :..|......|..|:
  Fly   237 HAMKAEYNGYC----FFNNVALA---------------------------TQHALDVHKLQRILI 270

  Fly   474 GDVAPPQAHAASTILPSSSSYMQQLGSVAGSGVNLHAAAVAAAAAAAAAAGSLPPTNSHGHG--- 535
            .|                              .::|                      ||.|
  Fly   271 ID------------------------------YDVH----------------------HGQGTQR 283

  Fly   536 -----------------HGSHAHPHPHAHGHGHGHGHGIYAGHQHNVPITDAQVAQVHLHKQGHR 583
                             |||. .||.|...: |..|.|...|:..|||:               .
  Fly   284 FFYNDPRVVYFSIHRFEHGSF-WPHLHESDY-HAIGSGAGTGYNFNVPL---------------N 331

  Fly   584 PLGRTQSAPLPLGHPMLTGAV-----QLNVVQTHYENS----EAERQ----AYEHQVVNQKVRQT 635
            ..|.|....|.:...:|....     :|.:|...|:.:    |.|.:    .|.| ::|..:|
  Fly   332 ATGMTNGDYLAIFQQLLLPVALEFQPELIIVSAGYDAALGCPEGEMEVTPACYPH-LLNPLLR-- 393

  Fly   636 VLTRSGAAAAAAAAAGVSVVREAQ--LKEEDDDSAAEVMDLTDKKKPPKTVLTSTIATSTSQNLP 698
                       .|.|.|:||.|..  |....:.:|..:..|.....||   |..|:.      ||
  Fly   394 -----------LADARVAVVLEGGYCLDSLAEGAALTLRSLLGDPCPP---LVETVP------LP 438

  Fly   699 EALAAAA--AAAAYRAPHNASSNSASATKSGIKLRDQEYLQQQREQLLLLQQEEELAKSLMRPLS 761
            .|..|.|  :..|...|| ........|...::|:|::             :||:|...|...:.
  Fly   439 RAELAQALLSCIAVHRPH-WRCLQLQQTYDCVELQDRD-------------KEEDLHTVLRHWIG 489

  Fly   762 RTLSSPLVPLGPHGLSQIPDTGQQPAPIATSSSADHIPPVNLSLPHRQHRQLMSTLYASQLRNHQ 826
                      ||..:.:.|          |..:|..:||..|            |..|::|:..:
  Fly   490 ----------GPPPMDRYP----------TRDTAIPLPPEKL------------TSNAARLQVLR 522

  Fly   827 PSASGS-PPHKVTTGLAYDPLMLKHSCICGDNAQHPEHSGRLQSVWARLNETDLVKRCDRLRARK 890
            .....| |..||.  .|||..||.| |...|.. |||...|:|.:....::..|:|:..:|..|.
  Fly   523 AETKLSVPSFKVC--YAYDAQMLLH-CNLNDTG-HPEQPSRIQHIHKMHDDYGLLKQMKQLSPRA 583

  Fly   891 ATQEELQTVHTEAHA----MLFGSNQCQLSRPKLENTLSASFVRLSCGGLGVDLDTTWNEHHTAT 951
            ||.:|:...||.||.    .|.|....:|.               ...|:   .::.:....|..
  Fly   584 ATTDEVCLAHTRAHVNTVRRLLGREPKELH---------------DAAGI---YNSVYLHPRTFD 630

  Fly   952 AARMAAGCVIDLALKTAKGDLRNGFAVVRPPGHHAEANLAMGFCFFNSIAIAAKLLRQRMPEVRR 1016
            .|.:|||.|:.......:|:.|:|...|||||||||.:...|||.||::||||:...:.. .:.|
  Fly   631 CATLAAGLVLQAVDSVLRGESRSGICNVRPPGHHAEQDHPHGFCIFNNVAIAAQYAIRDF-GLER 694

  Fly  1017 ILIVDWDVHHGNGTQQAFYQSPDILYLSIHRHDDGNFFP-GTGGPTE-CGSGAGLGFNVNISWSG 1079
            :||||||||||||||..|..:|.:||:|:||::.|:||| |..|..: .|.|||.||||||.|:
  Fly   695 VLIVDWDVHHGNGTQHIFESNPKVLYISLHRYEHGSFFPKGPDGNFDVVGKGAGRGFNVNIPWN- 758

  Fly  1080 ALNPPLGDAEYIAAFRTVVMPIARSFNPDIVLVSSGFDAATGHPAPLGGYHVSPACFGFMTRELL 1144
              ...:||.||..||:.::||||..|||.:||||:|||||.|.  ||||..|:...:|.:|..|.
  Fly   759 --KKGMGDLEYALAFQQLIMPIAYEFNPQLVLVSAGFDAAIGD--PLGGCKVTAEGYGMLTHWLS 819

  Fly  1145 QLANGKVVLALEGGYDLAAICDSAQECVRALLGD--PAAPIAKAELERPPC---QNAINTLQKTI 1204
            .||:|::::.|||||::.:|..:...|.:.||||  |...:....|::||.   |:.:.:||:.:
  Fly   820 ALASGRIIVCLEGGYNVNSISYAMTMCTKTLLGDPVPTPQLGATALQKPPTVAFQSCVESLQQCL 884

  Fly  1205 AIQQTHWPCVRMLEHTVGLSALETLKVEHDESETINAMAGLSMQSMHRTLSRDDS 1259
            .:|:.||   |.||. ||........|..:.:|..     |:....|..:|.||:
  Fly   885 QVQRNHW---RSLEF-VGRRLPRDPVVGENNNEDF-----LTASLRHLNISNDDA 930

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HDAC4	NP_001259507.1	iSH2_PI3K_IA_R	43..>87	CDD:304922
HDAC4	NP_001259507.1	HDAC_classIIa	837..1211	CDD:212544	148/384 (39%)
HDAC6	NP_001259569.1	HDAC10_HDAC6-dom1	119..457	CDD:212526	89/480 (19%)
		HDAC6-dom2	538..895	CDD:212527	149/385 (39%)
		zf-UBP	1007..1069	CDD:280334
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45458012
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0123
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D14578at50557
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100220
Panther	1	1.100	-	-	P	PTHR48252
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2991
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.780