DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HDAC4 and HDAC2

DIOPT Version :9

Sequence 1:	NP_001259507.1	Gene:	HDAC4 / 32278	FlyBaseID:	FBgn0041210	Length:	1269	Species:	Drosophila melanogaster
Sequence 2:	NP_001518.3	Gene:	HDAC2 / 3066	HGNCID:	4853	Length:	488	Species:	Homo sapiens

Alignment Length:	438	Identity:	100/438 - (22%)
Similarity:	168/438 - (38%)	Gaps:	99/438 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   860 HPEHSGRLQSVWARLNETDLVKRCDRLRARKATQEELQTVHTEAHAMLFGS----NQCQLSR--- 917
            ||....|::.....|....|.::.:..|..|||.||:...|::.:.....|    |..:.|:
Human    29 HPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQ 93

  Fly   918 --------PKLENTLSASFVRLSCGGLGVDLDTTWNEHHTATAARMAAGCVIDLALKTAKGDLRN 974
                    |..:...  .|.:||.|| .|......|...|..|...|.|.
Human    94 RFNVGEDCPVFDGLF--EFCQLSTGG-SVAGAVKLNRQQTDMAVNWAGGL--------------- 140

  Fly   975 GFAVVRPPGHHAEANLAMGFCFFNSIAIA-AKLLRQRMPEVRRILIVDWDVHHGNGTQQAFYQSP 1038
                     |||:.:.|.|||:.|.|.:| .:||:..    :|:|.:|.|:|||:|.::|||.:.
Human   141 ---------HHAKKSEASGFCYVNDIVLAILELLKYH----QRVLYIDIDIHHGDGVEEAFYTTD 192

  Fly  1039 DILYLSIHRHDDGNFFPGTGGPTECGSGAGLGFNVNISWSGALNPPLGDAEYIAAFRTVVMPIAR 1103
            .::.:|.|::  |.:|||||...:.|:|.|..:.||.    .:...:.|..|...|:.::..:..
Human   193 RVMTVSFHKY--GEYFPGTGDLRDIGAGKGKYYAVNF----PMRDGIDDESYGQIFKPIISKVME 251

  Fly  1104 SFNPDIVLVSSGFDAATGHPAPLGGYHVSPACFGFMTR------ELLQLANGKVVLALEGGYDL- 1161
            .:.|..|::..|.|:.:|.  .||       ||....:      |:::..|..:::...|||.:
Human   252 MYQPSAVVLQCGADSLSGD--RLG-------CFNLTVKGHAKCVEVVKTFNLPLLMLGGGGYTIR 307

  Fly  1162 ------------AAICDSAQECVRALLGDPAAPIAKAELERPPCQNAINTLQKTIAIQQTHWPCV 1214
                        |..|:...|.......:...|..|..:. |......||.:....|:|..:..:
Human   308 NVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHIS-PSNMTNQNTPEYMEKIKQRLFENL 371

  Fly  1215 RMLEHTVGLSALETLKVEHDESETINAMAGLSMQSMHRTLSRDDSEEP 1262
            |||.|..|:.                 |..:...::|.....:|.|:|
Human   372 RMLPHAPGVQ-----------------MQAIPEDAVHEDSGDEDGEDP 402

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HDAC4	NP_001259507.1	iSH2_PI3K_IA_R	43..>87	CDD:304922
HDAC4	NP_001259507.1	HDAC_classIIa	837..1211	CDD:212544	90/385 (23%)
HDAC2	NP_001518.3	HDAC2	9..374	CDD:212535	91/391 (23%)
		Histone deacetylase	9..322		81/338 (24%)
		CobT2	<386..>479	CDD:226920	4/17 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	389..488		4/14 (29%)
		RPN2_C	<436..>488	CDD:375480
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0123
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810