Protein Alignment HDAC4 and HDAC1

DIOPT Version :9

• Sequence 1: NP_001259507.1
• Gene: HDAC4 / 32278
• FlyBaseID: FBgn0041210
• Length: 1269
• Species: Drosophila melanogaster
• Sequence 2: NP_004955.2
• Gene: HDAC1 / 3065
• HGNCID: 4852
• Length: 482
• Species: Homo sapiens
• Alignment Length: 453
• Identity: 110/453 - (24%)
• Similarity: 177/453 - (39%)
• Gaps: 127/453 - (28%)

  Fly   860 HPEHSGRLQSVWARLNETDLVKRCDRLRARKATQEELQTVHTEAHAMLFGS----NQCQLSR--- 917
            ||....|::.....|....|.::.:..|..||..||:...|::.:.....|    |..:.|:
Human    28 HPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQ 92

  Fly   918 --------PKLENTLSASFVRLSCGGLGVDLDTTWNEHHTATAARMAAGCVIDLALKTAKGDLRN 974
                    |..:...  .|.:||.|| .|......|:..|..|...|.|.
Human    93 RFNVGEDCPVFDGLF--EFCQLSTGG-SVASAVKLNKQQTDIAVNWAGGL--------------- 139

  Fly   975 GFAVVRPPGHHAEANLAMGFCFFNSIAIA-AKLLRQRMPEVRRILIVDWDVHHGNGTQQAFYQSP 1038
                     |||:.:.|.|||:.|.|.:| .:||:..    :|:|.:|.|:|||:|.::|||.:.
Human   140 ---------HHAKKSEASGFCYVNDIVLAILELLKYH----QRVLYIDIDIHHGDGVEEAFYTTD 191

  Fly  1039 DILYLSIHRHDDGNFFPGTGGPTECGSGAGLGFNVNISWSGALNPPLGDAEYIAAFRTVVMPIAR 1103
            .::.:|.|::  |.:|||||...:.|:|.|..:.||.    .|...:.|..|.|.|:.|:..:..
Human   192 RVMTVSFHKY--GEYFPGTGDLRDIGAGKGKYYAVNY----PLRDGIDDESYEAIFKPVMSKVME 250

  Fly  1104 SFNPDIVLVSSGFDAATGHPAPLGGYHVSPACFGFMTR------ELLQLANGKVVLALEGGYDL- 1161
            .|.|..|::..|.|:.:|.  .||       ||....:      |.::..|..:::...|||.:
Human   251 MFQPSAVVLQCGSDSLSGD--RLG-------CFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIR 306

  Fly  1162 -AAICDSAQECVRALLGDPAAP-------------------IAKAELERPPCQNAINTLQKTIAI 1206
             .|.|.:.:..| ||  |...|                   |:.:.:..   ||....|:|   |
Human   307 NVARCWTYETAV-AL--DTEIPNELPYNDYFEYFGPDFKLHISPSNMTN---QNTNEYLEK---I 362

  Fly  1207 QQTHWPCVRMLEHTVGLSALETLKVEHDESETINAMAGLSMQSMHRTLSRDDS--EEPMDQDE 1267
            :|..:..:|||.|.                      .|:.||::     .:|:  ||..|:||
Human   363 KQRLFENLRMLPHA----------------------PGVQMQAI-----PEDAIPEESGDEDE 398

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HDAC4	NP_001259507.1	iSH2_PI3K_IA_R	43..>87	CDD:304922
		HDAC_classIIa	837..1211	CDD:212544	97/393 (25%)
HDAC1	NP_004955.2	HDAC1	4..374	CDD:212534	99/400 (25%)
		Histone deacetylase	9..321		88/341 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	390..482		5/9 (56%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0123
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810