Protein Alignment HDAC4 and Hdac1

DIOPT Version :9

• Sequence 1: NP_001259507.1
• Gene: HDAC4 / 32278
• FlyBaseID: FBgn0041210
• Length: 1269
• Species: Drosophila melanogaster
• Sequence 2: NP_001020580.1
• Gene: Hdac1 / 297893
• RGDID: 1309799
• Length: 482
• Species: Rattus norvegicus
• Alignment Length: 455
• Identity: 111/455 - (24%)
• Similarity: 185/455 - (40%)
• Gaps: 104/455 - (22%)

  Fly   860 HPEHSGRLQSVWARLNETDLVKRCDRLRARKATQEELQTVHTEAHAMLFGS----NQCQLSR--- 917
            ||....|::.....|....|.::.:..|..||..||:...|::.:.....|    |..:.|:
  Rat    28 HPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQ 92

  Fly   918 --------PKLENTLSASFVRLSCGGLGVDLDTTWNEHHTATAARMAAGCVIDLALKTAKGDLRN 974
                    |..:...  .|.:||.|| .|......|:..|..|...|.|.
  Rat    93 RFNVGEDCPVFDGLF--EFCQLSTGG-SVASAVKLNKQQTDIAVNWAGGL--------------- 139

  Fly   975 GFAVVRPPGHHAEANLAMGFCFFNSIAIA-AKLLRQRMPEVRRILIVDWDVHHGNGTQQAFYQSP 1038
                     |||:.:.|.|||:.|.|.:| .:||:..    :|:|.:|.|:|||:|.::|||.:.
  Rat   140 ---------HHAKKSEASGFCYVNDIVLAILELLKYH----QRVLYIDIDIHHGDGVEEAFYTTD 191

  Fly  1039 DILYLSIHRHDDGNFFPGTGGPTECGSGAGLGFNVNISWSGALNPPLGDAEYIAAFRTVVMPIAR 1103
            .::.:|.|::  |.:|||||...:.|:|.|..:.||.    .|...:.|..|.|.|:.|:..:..
  Rat   192 RVMTVSFHKY--GEYFPGTGDLRDIGAGKGKYYAVNY----PLRDGIDDESYEAIFKPVMSKVME 250

  Fly  1104 SFNPDIVLVSSGFDAATGHPAPLGGYHVSPACFGFMTR------ELLQLANGKVVLALEGGYDL- 1161
            .|.|..|::..|.|:.:|.  .||       ||....:      |.::..|..:::...|||.:
  Rat   251 MFQPSAVVLQCGSDSLSGD--RLG-------CFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIR 306

  Fly  1162 -AAICDSAQECVRALLGDPAAP-------------------IAKAELERPPCQNAINTLQKTIAI 1206
             .|.|.:.:..| ||  |...|                   |:.:.:..   ||....|:|   |
  Rat   307 NVARCWTYETAV-AL--DTEIPNELPYNDYFEYFGPDFKLHISPSNMTN---QNTNEYLEK---I 362

  Fly  1207 QQTHWPCVRMLEHTVG--LSAL--ETLKVEHDESETINAMAGLSMQSMHRTLSRDDSEEPMDQDE 1267
            :|..:..:|||.|..|  :.|:  :.:..|..:.:..:....:|:.|..:.::.:  ||..|.||
  Rat   363 KQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEEDPDKRISICSSDKRIACE--EEFSDSDE 425

  Fly  1268  1267
              Rat   426  425

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HDAC4	NP_001259507.1	iSH2_PI3K_IA_R	43..>87	CDD:304922
		HDAC_classIIa	837..1211	CDD:212544	97/393 (25%)
Hdac1	NP_001020580.1	HDAC1	4..374	CDD:212534	99/400 (25%)
		Histone deacetylase	9..321		88/341 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	390..482		8/38 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0123
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810