DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HDAC4 and Hdac11

DIOPT Version :9

Sequence 1:	NP_001259507.1	Gene:	HDAC4 / 32278	FlyBaseID:	FBgn0041210	Length:	1269	Species:	Drosophila melanogaster
Sequence 2:	NP_001100080.2	Gene:	Hdac11 / 297453	RGDID:	1311706	Length:	347	Species:	Rattus norvegicus

Alignment Length:	374	Identity:	87/374 - (23%)
Similarity:	141/374 - (37%)	Gaps:	104/374 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   818 YASQLRNHQPSASG----SPPHKVTTGLAYDPLMLKHSCICGDNAQHPEHSGRLQSVWARLNETD 878
            :|:||..|.|....    ||.:.:|              ..|....||..:|:...|...|.|..
  Rat     3 HATQLYQHVPEKRWPIVYSPRYNIT--------------FMGLEKLHPFDAGKWGKVINFLKEEK 53

  Fly   879 LVKRCDRLRARKATQEELQTVH-----------------TEAHAMLFGSN---QCQLSRPKLENT 923
            |:.....:.||:|::|:|..||                 ||...::|..|   |.::.||
  Rat    54 LLSDGMLVEAREASEEDLLVVHTRRYLNELKWSFVVATITEIPPVIFLPNFLVQRKVLRP----- 113

  Fly   924 LSASFVRLSCGGLGVDLDTTWNEHHTATAARMAA--GCVIDLALKTAKGDLRNGFAVVRPPGHHA 986
                 :|...||             |..|.::|.  |..|::.         .||       ||.
  Rat   114 -----LRTQTGG-------------TIMAGKLAVERGWAINVG---------GGF-------HHC 144

  Fly   987 EANLAMGFCFFNSIAIAAKLLRQRMPEVRRILIVDWDVHHGNGTQQAFYQSPDILYLSIH-RHDD 1050
            .::...|||.:..|.:|.|.|.:|:..:.|..|:|.|.|.|||.::.|.....:..:.:: ||
  Rat   145 SSDRGGGFCAYADITLAIKFLFERVEGISRATIIDLDAHQGNGHERDFMGDKRVYIMDVYNRH-- 207

  Fly  1051 GNFFPGTGGPTECGSGAGLGFNVNISWSGALNPPLGDAEYIAAFRTVVMPIARSFNPDIVLVSSG 1115
              .:||.....|     .:...|.:.|.      ..|.||:......|....:...||:|:.::|
  Rat   208 --IYPGDRFAKE-----AIRRKVELEWG------TEDEEYLEKVERNVRRSLQEHLPDVVVYNAG 259

  Fly  1116 FDAATGHPAPLGGYHVSPACFGFMTRE-----LLQLANGKVVLALEGGY 1159
            .|...|.  .|||..:|||  |.:.|:     :::..:..:::...|||
  Rat   260 TDVLEGD--RLGGLSISPA--GIVKRDEVVFRVVRAHDIPILMVTSGGY 304

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HDAC4	NP_001259507.1	iSH2_PI3K_IA_R	43..>87	CDD:304922
HDAC4	NP_001259507.1	HDAC_classIIa	837..1211	CDD:212544	80/351 (23%)
Hdac11	NP_001100080.2	HDAC_classIV	35..319	CDD:212519	78/328 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0123
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900