DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HDAC4 and hos2

DIOPT Version :9

Sequence 1:	NP_001259507.1	Gene:	HDAC4 / 32278	FlyBaseID:	FBgn0041210	Length:	1269	Species:	Drosophila melanogaster
Sequence 2:	NP_594079.1	Gene:	hos2 / 2543643	PomBaseID:	SPAC3G9.07c	Length:	434	Species:	Schizosaccharomyces pombe

Alignment Length:	404	Identity:	101/404 - (25%)
Similarity:	162/404 - (40%)	Gaps:	93/404 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   889 RKATQEELQTVHTEAHAMLFGSNQCQLSRPKLENT--LSASFVRLSCGGLGVDLDTTWNEHHTAT 951
            |.||..|:...|.|.:...       |.|...:|.  .:..|.:.:.|......|.|:.
pombe    74 RMATFGEMSEFHREDYLDF-------LKRVTPDNAEQFADKFQQFNIGDDCPVFDGTYE------ 125

  Fly   952 AARMAAGCVIDLALKTAKGDLRNGFAVVRPPG-HHAEANLAMGFCFFNSIAIAAKLLRQRMPEVR 1015
            .::.:||..:|.:.|..:|  :...|:....| |||:...|.|||:.|.|.:|...:.:..|
pombe   126 FSQRSAGASLDASRKLVQG--QTDIAINWSGGLHHAKRGEASGFCYVNDIVLAILNMLRFFP--- 185

  Fly  1016 RILIVDWDVHHGNGTQQAFYQSPDILYLSIHRHDDGNFFPGTGGPTECGSGAGLGFNVNISWSGA 1080
            |:|.:|.|:|||:|.|||||:|..:|.:|.|:: :|:|||.||...|.|...|..|.:|:    .
pombe   186 RVLYIDIDIHHGDGVQQAFYESDRVLTVSFHKY-NGDFFPATGNFDENGVKGGKYFALNV----P 245

  Fly  1081 LNPPLGDAEYIAAFRTVVMPIARSFNPDIVLVSSGFDAATGHPAPLGGY----------HVSPAC 1135
            |...:||.:|.:.|::::.|...:|.|..:::..|.|:.        ||          |....|
pombe   246 LEDGIGDEQYTSLFKSIIEPTINTFQPSAIVLQCGADSL--------GYDRLGVFNLSIHAHGEC 302

  Fly  1136 FGFMTRELLQLANGKVVLALEGGYDL----AAICDSAQECVRALLGDPAAPIAKAELERPPCQNA 1196
            ..| ||..    |..:::...|||.|    .|.|.....||.               |:.|.:..
pombe   303 VRF-TRSF----NIPMLVVGGGGYTLRNVARAWCYETSICVN---------------EQIPSELP 347

  Fly  1197 INTL-------------QKTIAIQQTHWPCVRMLEHTVGLSALETLKVEH-DESETINAMAGLSM 1247
            ..||             :.|..|:..:.|           .|||.|::.. ::...:.....:.|
pombe   348 RETLYYEFFAPDYTLHPRLTTKIENKNTP-----------KALEDLRIRALEQLRYLGGAPSVQM 401

  Fly  1248 QSMHRTLSRDDSEE 1261
            |.:...|:....||
pombe   402 QQIPPDLTGHLEEE 415

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HDAC4	NP_001259507.1	iSH2_PI3K_IA_R	43..>87	CDD:304922
HDAC4	NP_001259507.1	HDAC_classIIa	837..1211	CDD:212544	91/351 (26%)
hos2	NP_594079.1	PTZ00063	25..426	CDD:240251	101/404 (25%)
hos2	NP_594079.1	HDAC_Hos2	28..337	CDD:212540	83/298 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0123
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810