DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HDAC4 and clr3

DIOPT Version :9

Sequence 1:	NP_001259507.1	Gene:	HDAC4 / 32278	FlyBaseID:	FBgn0041210	Length:	1269	Species:	Drosophila melanogaster
Sequence 2:	NP_595104.1	Gene:	clr3 / 2540821	PomBaseID:	SPBC800.03	Length:	687	Species:	Schizosaccharomyces pombe

Alignment Length:	423	Identity:	164/423 - (38%)
Similarity:	241/423 - (56%)	Gaps:	50/423 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   816 TLYASQLRNHQPSASGS------PPHKVT-----TGLAYDPLMLKHSCICGDNAQHPEHSGRLQS 869
            |.::..|.|::| .|||      ..|:::     :||.|||.|..|:.: .:...|||...|:..
pombe    24 TPWSILLTNNKP-MSGSENTLNNESHEMSQILKKSGLCYDPRMRFHATL-SEVDDHPEDPRRVLR 86

  Fly   870 VWARLNETDLVKRCD-------RLRARKATQEELQTVHT-EAHAMLFGSNQCQLSRPKLENTLSA 926
            |:..:.:...|....       |:.||:||.|||..||: |.:..:  :|..::|...|.|....
pombe    87 VFEAIKKAGYVSNVPSPSDVFLRIPAREATLEELLQVHSQEMYDRV--TNTEKMSHEDLANLEKI 149

  Fly   927 SFVRLSCGGLGVDLDTTWNEHHTATAARMAAGCVIDLALKTAKGDLRNGFAVVRPPGHHAEANLA 991
            |             |:.:..:.:|..||:|.|..|:.......|.::|.||||||||||||.:..
pombe   150 S-------------DSLYYNNESAFCARLACGSAIETCTAVVTGQVKNAFAVVRPPGHHAEPHKP 201

  Fly   992 MGFCFFNSIAIAAKLLRQRMPE-VRRILIVDWDVHHGNGTQQAFYQSPDILYLSIHRHDDGNFFP 1055
            .|||.||::::.|:.:.||.|: ::|:||||||:|||||||.|||..|::||:|:||:::|.|:|
pombe   202 GGFCLFNNVSVTARSMLQRFPDKIKRVLIVDWDIHHGNGTQMAFYDDPNVLYVSLHRYENGRFYP 266

  Fly  1056 GT--GGPTECGSGAGLGFNVNISWSGALNPPLGDAEYIAAFRTVVMPIARSFNPDIVLVSSGFDA 1118
            ||  |....||.|.|||..|||.||.|   .:||.:||.||:.||||:|..|:||:|:||.||||
pombe   267 GTNYGCAENCGEGPGLGRTVNIPWSCA---GMGDGDYIYAFQRVVMPVAYEFDPDLVIVSCGFDA 328

  Fly  1119 ATG-HPAPLGGYHVSPACFGFMTRELLQLANGKVVLALEGGYDLAAICDSAQECVRALLGDPAAP 1182
            |.| |   :|.:.::||.:..||:.|:.||:|||.::|||||:|.:|..||....::|||.|...
pombe   329 AAGDH---IGQFLLTPAAYAHMTQMLMGLADGKVFISLEGGYNLDSISTSALAVAQSLLGIPPGR 390

  Fly  1183 IAKAELERPPCQNAINTLQKTIAIQQTHWPCVR 1215
            :....    .|..|:.|:.....||..:|.|:|
pombe   391 LHTTY----ACPQAVATINHVTKIQSQYWRCMR 419

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HDAC4	NP_001259507.1	iSH2_PI3K_IA_R	43..>87	CDD:304922
HDAC4	NP_001259507.1	HDAC_classIIa	837..1211	CDD:212544	153/390 (39%)
clr3	NP_595104.1	HDAC_Clr3	75..392	CDD:212542	141/337 (42%)
clr3	NP_595104.1	Arb2	398..562	CDD:286800	7/22 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0123
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		oto101871
orthoMCL	1	0.900	-	-		OOG6_100220
Panther	1	1.100	-	-	O	PTHR48252
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2991
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.840