DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HDAC4 and F43G6.17

DIOPT Version :9

Sequence 1:	NP_001259507.1	Gene:	HDAC4 / 32278	FlyBaseID:	FBgn0041210	Length:	1269	Species:	Drosophila melanogaster
Sequence 2:	NP_001263677.1	Gene:	F43G6.17 / 24104581	WormBaseID:	WBGene00219378	Length:	281	Species:	Caenorhabditis elegans

Alignment Length:	199	Identity:	50/199 - (25%)
Similarity:	84/199 - (42%)	Gaps:	50/199 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly  1087 DAEYIAAFRTVVMPIARSFNPDIVLVSSGFDAATGHPAPLGGYH---------VSPACFGFMTRE 1142
            :.:|::.|..|::.:...|.|:::|:|:|||:         ||:         |....:|.|...
Worm     4 EGDYVSVFHHVLLTMLEQFQPELILISAGFDS---------GYYDVMMEFGQGVKANGYGHMACL 59

  Fly  1143 LLQLANGKVVLALEGGYDLAAICDSAQECVRALLGDPAAPIAKAELERPPCQNAINTLQKTIAIQ 1207
            |.|:..||::..|||||......:||...||.||.   .||.:.::..          :.:.|:.
Worm    60 LNQICPGKILAILEGGYHPYNYTESASMMVRGLLN---LPIPRLDIPE----------RISGALL 111

  Fly  1208 QTHWPCVRMLEH------TVGLSALETLK-VEHDESETINAMAGLSMQSMHRTLSRDDSEEPMDQ 1265
            :|.|   .:|.|      .:|    |.|| :||.:.|     .||...:..:|:...:....|..
Worm   112 ETTW---NILNHHSEWYPKLG----ERLKLLEHQQKE-----LGLPQFAFDQTMFLGEKMRKMYD 164

  Fly  1266 DETK 1269
            |..|
Worm   165 DMKK 168

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HDAC4	NP_001259507.1	iSH2_PI3K_IA_R	43..>87	CDD:304922
HDAC4	NP_001259507.1	HDAC_classIIa	837..1211	CDD:212544	34/132 (26%)
F43G6.17	NP_001263677.1	Arginase_HDAC	<1..125	CDD:388375	37/145 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1484694at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920