Protein Alignment HDAC4 and Hdac4

DIOPT Version :9

• Sequence 1: NP_001259507.1
• Gene: HDAC4 / 32278
• FlyBaseID: FBgn0041210
• Length: 1269
• Species: Drosophila melanogaster
• Sequence 2: XP_006529374.1
• Gene: Hdac4 / 208727
• MGIID: 3036234
• Length: 1100
• Species: Mus musculus
• Alignment Length: 1339
• Identity: 457/1339 - (34%)
• Similarity: 658/1339 - (49%)
• Gaps: 373/1339 - (27%)

  Fly     8 IPIHDLPSEAGSDERLLHITPATLTLDFKPHPAV---DIDQQIMELKKSQELQKQRLINSFQEQS 69
            :|:...|:....|.||.|  ..:|.|:    ||:   .:.|:::.||:.|::|:|.||..||.|.
Mouse    52 LPLQVAPTAVPMDLRLDH--QFSLPLE----PALREQQLQQELLALKQKQQIQRQILIAEFQRQH 110

  Fly    70 KQMELEHKLQL-EHKYQKQPTNKRFSLELIVIIQFAVNSHGAFQELRNESMVTAAAAAVAQEQHR 133
            :|:..:|:.|| ||..|:|        |::.:                              :|:
Mouse   111 EQLSRQHEAQLHEHIKQQQ--------EMLAM------------------------------KHQ 137

  Fly   134 QQL--HQQQ-QQHQQQQQ-QQQHQQQQQQQQARGRDGMKLKQNCSANASPEVKQILNCFILSRKS 194
            |:|  ||:: ::|:|:|: ::||::|:.||......|.:     ||.||.|||..|..|:|::|.
Mouse   138 QELLEHQRKLERHRQEQELEKQHREQKLQQLKNKEKGKE-----SAVASTEVKMKLQEFVLNKKK 197

  Fly   195 QAAAS--NGTTTTSPYRNRGVVKSSS--GESLPAGTVTSAHPYKIPQPPPSLLKYES--DFPLRK 253
            ..|..  |...::.|....|..:.||  ..|.|...|::::.:      |.|..|::  ||||||
Mouse   198 ALAHRNLNHCISSDPRYWYGKTQHSSLDQSSPPQSGVSASYNH------PVLGMYDAKDDFPLRK 256

  Fly   254 TASEPNL-LKIRLKQSVIERKA-----RIGGPAGARRHERLLQAAQRRQQKNSVLTNCNSTPDSG 312
            ||||||| |:.||||.|.||::     |..||......:|.|....         :.|:|.|.||
Mouse   257 TASEPNLKLRSRLKQKVAERRSSPLLRRKDGPVATALKKRPLDVTD---------SACSSAPGSG 312

  Fly   313 PNSPPSAAALAVGVVGSRG--SPT--SAPIQEE------NEEGSQYQPGQRSSINDLPLFSSPSL 367
            |:||.|::    |.|.:..  :||  |||.:..      ..||         |:..|||::||||
Mouse   313 PSSPNSSS----GNVSTENGIAPTVPSAPAETSLAHRLVTREG---------SVAPLPLYTSPSL 364

  Fly   368 PNISLGRPHLPNSAQAHAQVNAQVAAQAQAQAQAQAQAHAMFAALAAAQGGCGQPGYYNPLGMAF 432
            |||:||.|....:|.|..|.:|:..|....|.:
Mouse   365 PNITLGLPATGPAAGAAGQQDAERLALPALQQR-------------------------------- 397

  Fly   433 VGRQPAPLAMIPATGIAPQ-QPSPVVRSASATSTSSSQASLVGDVAPPQAHAASTILPSSSSYMQ 496
                    .:.|.|.:.|. ..||:.|..:|......|..::.:..|.|....      :..|:.
Mouse   398 --------ILFPGTHLTPYLSTSPLERDGAAAHNPLLQHMVLLEQPPTQTPLV------TDWYLS 448

  Fly   497 QLGSVAGSGVNLHAAAVAAAAAAAAAAGSLPPTNSHGHGHGSHAHPHPHAHGHGHGHGHGIYAGH 561
            .||::.     ||:.::..|
Mouse   449 GLGALP-----LHSQSLVGA--------------------------------------------- 463

  Fly   562 QHNVPITDAQVAQVHLHKQGHRPLGRTQSAPLPLGHPMLTGAVQLNVVQTHYENSEAERQAYEHQ 626
                   |.....:|..:| |||||||||||||                   :|:    ||.:|.
Mouse   464 -------DRVSPSIHKLRQ-HRPLGRTQSAPLP-------------------QNA----QALQHL 497

  Fly   627 VVNQKVRQTVLTRSGAAAAAAAAAGVSVVREAQLKEEDDDSAAEVMDLTDK-KKPPKTVLTSTIA 690
            |:.|:.:|.:                     .:.|::.......:..:..| .:||
Mouse   498 VIQQQHQQFL---------------------EKHKQQFQQQQLHLSKIISKPSEPP--------- 532

  Fly   691 TSTSQNLPEALAAAAAAAAYRAPHNASSNSASATKSGIKLRDQEYLQQ---QREQLLL------- 745
                                |.|.:....:....:....|.|:.||.:   |:|..|.
Mouse   533 --------------------RQPESHPEETEEELREHQALLDEPYLDRLPGQKEPSLAGVQVKQE 577

  Fly   746 -LQQEEELAKSLMRPLSRTLSSPLVPLGPHGLSQIPDTGQQPAPIATSSSADHIPPVNLSLPHRQ 809
             ::.|||.|::                     ::..:.||:||             ....|..||
Mouse   578 PIESEEEEAEA---------------------TRETEPGQRPA-------------TEQELLFRQ 608

  Fly   810 HRQLMSTLYASQLRNHQPS--ASG----------------------------SPPHK--VTTGLA 842
            ...|:......||||:|.|  |:|                            .||.|  .||||.
Mouse   609 QALLLEQQRIHQLRNYQASMEAAGIPVSFGSHRPLSRAQSSPASATFPMSVQEPPTKPRFTTGLV 673

  Fly   843 YDPLMLKHSCICGDNAQHPEHSGRLQSVWARLNETDLVKRCDRLRARKATQEELQTVHTEAHAML 907
            ||.|||||.|.||:...||||:||:||:|:||.||.|..:|:.:|.||||.|||||||:|||.:|
Mouse   674 YDTLMLKHQCTCGNTNSHPEHAGRIQSIWSRLQETGLRGKCECIRGRKATLEELQTVHSEAHTLL 738

  Fly   908 FGSNQCQLSRPKLEN-----TLSASFVRLSCGGLGVDLDTTWNEHHTATAARMAAGCVIDLALKT 967
            :|:|  .|:|.||::     :|::.||||.|||:|||.||.|||.|::.|||:|.|||::|..|.
Mouse   739 YGTN--PLNRQKLDSKKLLGSLTSVFVRLPCGGVGVDSDTIWNEVHSSGAARLAVGCVVELVFKV 801

  Fly   968 AKGDLRNGFAVVRPPGHHAEANLAMGFCFFNSIAIAAKLLRQRMPEVRRILIVDWDVHHGNGTQQ 1032
            |.|:|:||||||||||||||.:..||||:|||:|:|||||:||: .|.:||||||||||||||||
Mouse   802 ATGELKNGFAVVRPPGHHAEESTPMGFCYFNSVAVAAKLLQQRL-NVSKILIVDWDVHHGNGTQQ 865

  Fly  1033 AFYQSPDILYLSIHRHDDGNFFPGTGGPTECGSGAGLGFNVNISWSGALNPPLGDAEYIAAFRTV 1097
            |||..|::||:|:||:||||||||:|.|.|.|:|.|:|||||::::|.|.||:|||||:||||||
Mouse   866 AFYNDPNVLYMSLHRYDDGNFFPGSGAPDEVGTGPGVGFNVNMAFTGGLEPPMGDAEYLAAFRTV 930

  Fly  1098 VMPIARSFNPDIVLVSSGFDAATGHPAPLGGYHVSPACFGFMTRELLQLANGKVVLALEGGYDLA 1162
            |||||..|.||:|||||||||..|||.|||||::|..|||::|::|:.||.|::|||||||:||.
Mouse   931 VMPIANEFAPDVVLVSSGFDAVEGHPTPLGGYNLSAKCFGYLTKQLMGLAGGRLVLALEGGHDLT 995

  Fly  1163 AICDSAQECVRALLGDPAAPIAKAELERPPCQNAINTLQKTIAIQQTHWPCVRMLEHTVGLSALE 1227
            ||||:::.||.||||:...|:.:..|.:.|..||:::::|.:.|...:|.|::.|..|||.|.:|
Mouse   996 AICDASEACVSALLGNELEPLPEKVLHQRPNANAVHSMEKVMDIHSKYWRCLQRLSSTVGHSLIE 1060

  Fly  1228 TLKVEHDESETINAMAGLSMQSMHRTLSRDDSEEPMDQD 1266
            ..|.|.:|:||:.|||.||:..  :...:...||||:::
Mouse  1061 AQKCEKEEAETVTAMASLSVGV--KPAEKRSEEEPMEEE 1097

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HDAC4	NP_001259507.1	iSH2_PI3K_IA_R	43..>87	CDD:304922	18/44 (41%)
		HDAC_classIIa	837..1211	CDD:212544	229/378 (61%)
Hdac4	XP_006529374.1	ClassIIa_HDAC4_Gln-rich-N	<104..165	CDD:197398	23/98 (23%)
		HDAC4	665..1073	CDD:212530	243/410 (59%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	453	1.000	Domainoid score	I499
eggNOG	1	0.900	-	-		E1_COG0123
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	557	1.000	Inparanoid score	I1103
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46994
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001001
OrthoInspector	1	1.000	-	-		otm44037
orthoMCL	1	0.900	-	-		OOG6_100220
Panther	1	1.100	-	-	LDO	PTHR48252
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2991
SonicParanoid	1	1.000	-	-		X933
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	11.900