Protein Alignment HDAC4 and hdac1

DIOPT Version :9

• Sequence 1: NP_001259507.1
• Gene: HDAC4 / 32278
• FlyBaseID: FBgn0041210
• Length: 1269
• Species: Drosophila melanogaster
• Sequence 2: XP_005159649.1
• Gene: hdac1 / 192302
• ZFINID: ZDB-GENE-020419-32
• Length: 484
• Species: Danio rerio
• Alignment Length: 452
• Identity: 109/452 - (24%)
• Similarity: 185/452 - (40%)
• Gaps: 105/452 - (23%)

  Fly   860 HPEHSGRLQSVWARLNETDLVKRCDRLRARKATQEELQTVHTEAHAMLFGS----NQCQLSR--- 917
            ||....|::.....|....|.::.:..|..||..||:...|::.:.....|    |..:.|:
Zfish    29 HPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQ 93

  Fly   918 --------PKLENTLSASFVRLSCGGLGVDLDTTWNEHHTATAARMAAGCVIDLALKTAKGDLRN 974
                    |..:...  .|.:||.|| .|......|:..|..|...|.|.
Zfish    94 RFNVGEDCPVFDGLF--EFCQLSTGG-SVAGAVKLNKQQTDIAINWAGGL--------------- 140

  Fly   975 GFAVVRPPGHHAEANLAMGFCFFNSIAIA-AKLLRQRMPEVRRILIVDWDVHHGNGTQQAFYQSP 1038
                     |||:.:.|.|||:.|.|.:| .:||:..    :|:|.:|.|:|||:|.::|||.:.
Zfish   141 ---------HHAKKSEASGFCYVNDIVLAILELLKYH----QRVLYIDIDIHHGDGVEEAFYTTD 192

  Fly  1039 DILYLSIHRHDDGNFFPGTGGPTECGSGAGLGFNVNISWSGALNPPLGDAEYIAAFRTVVMPIAR 1103
            .::.:|.|::  |.:|||||...:.|:|.|..:.||.    .|...:.|..|.|.|:.::..:..
Zfish   193 RVMTVSFHKY--GEYFPGTGDLRDIGAGKGKYYAVNY----PLRDGIDDESYEAIFKPIMSKVME 251

  Fly  1104 SFNPDIVLVSSGFDAATGHPAPLGGYHVSPACFGFMTR------ELLQLANGKVVLALEGGYDL- 1161
            .:.|..|::..|.|:.:|.  .||       ||....:      |.::..|..:::...|||.:
Zfish   252 MYQPSAVVLQCGADSLSGD--RLG-------CFNLTIKGHAKCVEYMKSFNLPLLMLGGGGYTIR 307

  Fly  1162 -AAICDSAQECVRALLGDPAAP-------------------IAKAELERPPCQNAINTLQKTIAI 1206
             .|.|.:.:..| ||  |...|                   |:.:.:..   ||..:.|:|   |
Zfish   308 NVARCWTFETAV-AL--DSTIPNELPYNDYFEYFGPDFKLHISPSNMTN---QNTNDYLEK---I 363

  Fly  1207 QQTHWPCVRMLEHTVG--LSALETLKVEHDE-SETINAMAGLSMQSMHRTLSRD----DSEE 1261
            :|..:..:|||.|..|  :.|:....|:.|. .|..:....:|:::..:.::.|    |||:
Zfish   364 KQRLFENLRMLPHAPGVQMQAIPEDAVQEDSGDEEDDPDKRISIRAHDKRIACDEEFSDSED 425

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HDAC4	NP_001259507.1	iSH2_PI3K_IA_R	43..>87	CDD:304922
		HDAC_classIIa	837..1211	CDD:212544	95/393 (24%)
hdac1	XP_005159649.1	HDAC1	5..375	CDD:212534	97/400 (24%)
		PTZ00063	8..406	CDD:240251	104/431 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0123
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810