DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HDAC4 and hda-11

DIOPT Version :9

Sequence 1:	NP_001259507.1	Gene:	HDAC4 / 32278	FlyBaseID:	FBgn0041210	Length:	1269	Species:	Drosophila melanogaster
Sequence 2:	NP_505699.3	Gene:	hda-11 / 183226	WormBaseID:	WBGene00007953	Length:	334	Species:	Caenorhabditis elegans

Alignment Length:	373	Identity:	81/373 - (21%)
Similarity:	128/373 - (34%)	Gaps:	110/373 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   860 HPEHSGRLQSVWARLNETDLVKRCDRLRARKATQEELQTVHTEAHAMLFGSNQCQLSRP-KLENT 923
            ||..|.:.:.|...|.|.:|:.....:.....|.|||..||...:..       .:..| |....
Worm    36 HPFDSSKWRRVITHLKEMNLITDETLVEPNLPTFEELTRVHDRKYLK-------SVRNPIKAAQI 93

  Fly   924 LSASFV----------------RLSCGGLGVDLDTTWNEHHTATAARMAAGCVIDLALKTAKGDL 972
            :...||                ||..||             |..||.:|               |
Worm    94 VEIPFVGCLPPCIIESKLLHPLRLQAGG-------------TVLAANLA---------------L 130

  Fly   973 RNGFAVVRPPG-HHAEANLAMGFCFFNSIAIAAKLLRQRMPEVRRILIVDWDVHHGNGTQQAFYQ 1036
            ::|:|:....| |||..:...||||:..|.:|...|..: ..:...::||.|.|.|||..:.|..
Worm   131 KHGWAINVGGGFHHASHSGGGGFCFYADITMAIFDLFDK-KAIANAIVVDLDAHQGNGHARDFAD 194

  Fly  1037 SPDIL-------YLSIHRHDDGNFFPGTGGPTECGSGAGLGFNVNISWSGALNPPLGDAEYIAAF 1094
            :|::.       |:..|..:...|                     |:.:..:|....|..|::..
Worm   195 NPNVFVFDVFNPYVYPHDREARQF---------------------INRAVHVNGHTTDTSYLSEL 238

  Fly  1095 R----TVVMPIARSFNP--DIVLVSSGFDAATGHPAPLGGYHVSPACFGFMTRELLQLANGK--- 1150
            |    ..::...::..|  |.::.::|.|...|.  |||...:||.|.......:..||..|
Worm   239 RKQLAQCLIDREKTTPPGFDFIMFNAGTDCLLGD--PLGAMKLSPQCIIARDEVVFNLAKSKGIP 301

  Fly  1151 VVLALEGGYDLAAICDSAQECVRALLGDPAAPIAKAELERPPCQNAIN 1198
            :.:...|||.                .|.|..|||: :|....:|.|:
Worm   302 ICMVTSGGYQ----------------KDNALLIAKS-IENLQSKNLIS 332

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HDAC4	NP_001259507.1	iSH2_PI3K_IA_R	43..>87	CDD:304922
HDAC4	NP_001259507.1	HDAC_classIIa	837..1211	CDD:212544	81/373 (22%)
hda-11	NP_505699.3	HDAC_classIV	36..325	CDD:212519	79/364 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0123
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810