DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HDAC4 and hda-1

DIOPT Version :9

Sequence 1:	NP_001259507.1	Gene:	HDAC4 / 32278	FlyBaseID:	FBgn0041210	Length:	1269	Species:	Drosophila melanogaster
Sequence 2:	NP_506599.1	Gene:	hda-1 / 179959	WormBaseID:	WBGene00001834	Length:	461	Species:	Caenorhabditis elegans

Alignment Length:	295	Identity:	74/295 - (25%)
Similarity:	132/295 - (44%)	Gaps:	52/295 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   879 LVKRCDRLRARKATQEELQTVHTEAHAMLFGS----NQCQLSRPKLENTLSA---------SFVR 930
            |.:..:..|...|:.|::...|::.:.....|    |....::..|:..:..         .|.:
Worm    51 LYRNLEIFRPFPASFEDMTRFHSDEYMTFLKSANPDNLKSFNKQMLKFNVGEDCPLFDGLYEFCQ 115

  Fly   931 LSCGGLGVDLDTTWNEHHTATAARMAAGCVIDLALKTAKGDLRNGFAVVRPPGHHAEANLAMGFC 995
            ||.||             :..||.......:|:|:....|            .|||:.:.|.|||
Worm   116 LSSGG-------------SLAAATKLNKQKVDIAINWMGG------------LHHAKKSEASGFC 155

  Fly   996 FFNSIAIA-AKLLRQRMPEVRRILIVDWDVHHGNGTQQAFYQSPDILYLSIHRHDDGNFFPGTGG 1059
            :.|.|.:. .:||:..    :|:|.||.|||||:|.::|||.:..::.:|.|::  |:||||||.
Worm   156 YTNDIVLGILELLKYH----KRVLYVDIDVHHGDGVEEAFYTTDRVMTVSFHKY--GDFFPGTGD 214

  Fly  1060 PTECGSGAGLGFNVNISWSGALNPPLGDAEYIAAFRTVVMPIARSFNPDIVLVSSGFDAATGHPA 1124
            ..:.|:|.|..::||:    .|...:.|..|.:.|:.::..:...|:|..|::..|.|:..|.
Worm   215 LKDIGAGKGKLYSVNV----PLRDGITDVSYQSIFKPIMTKVMERFDPCAVVLQCGADSLNGD-- 273

  Fly  1125 PLGGYHVSPACFGFMTRELLQLANGKVVLALEGGY 1159
            .||.::::....|...| ..:..|..:::...|||
Worm   274 RLGPFNLTLKGHGECAR-FFRSYNVPLMMVGGGGY 307

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HDAC4	NP_001259507.1	iSH2_PI3K_IA_R	43..>87	CDD:304922
HDAC4	NP_001259507.1	HDAC_classIIa	837..1211	CDD:212544	74/295 (25%)
hda-1	NP_506599.1	HDAC_classI	18..323	CDD:212517	74/295 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0123
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810