DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HDAC4 and hda-6

DIOPT Version :9

Sequence 1:	NP_001259507.1	Gene:	HDAC4 / 32278	FlyBaseID:	FBgn0041210	Length:	1269	Species:	Drosophila melanogaster
Sequence 2:	NP_001122780.1	Gene:	hda-6 / 177316	WormBaseID:	WBGene00018319	Length:	957	Species:	Caenorhabditis elegans

Alignment Length:	877	Identity:	231/877 - (26%)
Similarity:	347/877 - (39%)	Gaps:	243/877 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   467 SSQASLVGDVAPPQAHAASTILPSSSSYMQQLGSVAGSGVNLHAAAVAAAAAAAAAAGS----LP 527
            :::||....|..|..|.|.::.|........               ||.||..|..:|:    :.
Worm   132 ANEASNGFAVVRPPGHHADSVSPCGFCLFNN---------------VAQAAEEAFFSGAERILIV 181

  Fly   528 PTNSHGHGHGS---------------HAHPH----PHAHGHGHGH-GHGIYAGHQHNVPI----- 567
            ..:.| ||||:               |.|.|    ||.......| |.|...|:..|:.:
Worm   182 DLDVH-HGHGTQRIFYDDKRVLYFSIHRHEHGLFWPHLPESDFDHIGSGKGLGYNANLALNETGC 245

  Fly   568 TDAQVAQVHLHKQGHRPLGRTQSAPL--------------PLGHPMLTGAVQLNVVQTHYENSEA 618
            ||:....:..|..  .||. ||..|.              |||...||.....:::. |.::...
Worm   246 TDSDYLSIIFHVL--LPLA-TQFDPHFVIISAGFDALLGDPLGGMCLTPDGYSHILY-HLKSLAQ 306

  Fly   619 ERQ------AYEHQVVNQKVRQTVLTRSGAAAAAAAAAGVSVVREAQLKEEDDDSAAEVMDLTDK 677
            .|.      .|.||:....|::.|....|.|.       .|:......||...||...::.:
Worm   307 GRMLVVLEGGYNHQISAVAVQRCVRVLLGYAP-------FSIELNEAPKESTVDSCVSLVSV--- 361

  Fly   678 KKPPKTVLTSTIATSTSQNLPEALAAAAAAAAYRAPHNASSNSASATKSGIKLRDQ----EYLQQ 738
                                                                ||..    :|. .
Worm   362 ----------------------------------------------------LRHHWNCFDYF-P 373

  Fly   739 QREQLLLLQQEEELAKSLMR--PLSRTLSSPLVPLGPHGLSQIPDTGQ--QPAPIATS-SSADHI 798
            .|..|.|.|......|.:..  |.:|.                .|||:  |....:|. :::|.|
Worm   374 SRTSLRLAQWPIVNTKVIYNYDPTTRR----------------ADTGEIIQDELASTEFTASDVI 422

  Fly   799 PPVNLSLPHRQHRQLMSTLYASQLRNHQPSASGSPPHKVTTGLAYDPLMLKHSCICGDNA----- 858
            |..|:.          :.:|.::                                 ||:|
Worm   423 PTENME----------TLIYFNE---------------------------------GDDAHFDLE 444

  Fly   859 --QHPEHSGRLQSVWARLNETDLVKRC-DRLRARKATQEELQTVHTEAHAMLFGSNQCQLSRPKL 920
              .|||...|.:.:...|.|:.::::| ||...|.||.||::.|||:.......:.:.......:
Worm   445 EDNHPEKPARTRRILKTLRESGVLEKCVDRNCERIATNEEIRLVHTKKMLEHLRTTETMKDEELM 509

  Fly   921 ENTLSASFVRLSCGGLGVDLDTTWNEHHTATAARMAAGCVIDLALKTAKGDL--RNGFAVVRPPG 983
            |....             :.::.:....|...||.|.|.|:....:..:.|.  ||...:|||||
Worm   510 EEAEK-------------EFNSIYLTRDTLKVARKAVGAVLQSVDEIFEKDAGQRNALVIVRPPG 561

  Fly   984 HHAEANLAMGFCFFNSIAIAAKLLRQRMPEVRRILIVDWDVHHGNGTQQAFYQSPDILYLSIHRH 1048
            |||.|:.:.|||.||::|:||| ..||..:.:|:||:|||||||||||:.||:..:::|:|||||
Worm   562 HHASASKSSGFCIFNNVAVAAK-YAQRRHKAKRVLILDWDVHHGNGTQEIFYEDSNVMYMSIHRH 625

  Fly  1049 DDGNFFPGTGGP---TECGSGAGLGFNVNISWSGALNPPLGDAEYIAAFRTVVMPIARSFNPDIV 1110
            |.|||:| .|.|   ::.|.|||.|.:||:.:||.   .:||.||..||:.|:||||..||||:|
Worm   626 DKGNFYP-IGEPKDYSDVGEGAGEGMSVNVPFSGV---QMGDNEYQMAFQRVIMPIAYQFNPDLV 686

  Fly  1111 LVSSGFDAATGHPAPLGGYHVSPACFGFMTRELLQLANGKVVLALEGGYDLAAICDSAQECVRAL 1175
            |:|:|||||...  |||.|.|:|..|..||.:|..||.|:::..|||||:|.:|.:|||.....|
Worm   687 LISAGFDAAVDD--PLGEYKVTPETFALMTYQLSSLAGGRIITVLEGGYNLTSISNSAQAVCEVL 749

  Fly  1176 LGDPAAPIAKAELERPPCQ------NAINTLQKTIAIQQTHWPCVRMLEHTVGLSALETLKVEHD 1234
            .........:.|.|:...:      :.|.|:::..|:||.:|..::..:.|.....|:.....:|
Worm   750 QNRSMLRRLREEKEQFATKPQKIESSCIKTIREVCAVQQKYWSILKGFQVTPSNYGLDIDDEAYD 814

  Fly  1235 ESETINAMAGLSMQSMHRTLSRDDSE--EPMD 1264
            : ::|: ||..|..|...:.|...|.  |.||
Worm   815 D-DSID-MADQSSSSGSSSSSTRPSHNLEIMD 844

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HDAC4	NP_001259507.1	iSH2_PI3K_IA_R	43..>87	CDD:304922
HDAC4	NP_001259507.1	HDAC_classIIa	837..1211	CDD:212544	142/392 (36%)
hda-6	NP_001122780.1	Arginase_HDAC	32..366	CDD:388375	57/315 (18%)
		Arginase_HDAC	440..795	CDD:388375	140/374 (37%)
		zf-UBP	877..939	CDD:366940
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1484694at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100220
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2991
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.850