DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HDAC4 and hda-5

DIOPT Version :9

Sequence 1:	NP_001259507.1	Gene:	HDAC4 / 32278	FlyBaseID:	FBgn0041210	Length:	1269	Species:	Drosophila melanogaster
Sequence 2:	NP_741051.1	Gene:	hda-5 / 174811	WormBaseID:	WBGene00009663	Length:	508	Species:	Caenorhabditis elegans

Alignment Length:	447	Identity:	130/447 - (29%)
Similarity:	204/447 - (45%)	Gaps:	77/447 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   840 GLAYDPLMLKHSCICGDN-AQHPEHSGRLQSVWARLNETDLVKRCDRLRARKATQEELQTVHTEA 903
            |..||..||.|.|..... |:.|:   |::.::.||.:..|:....::.||:|...|::..|.:
Worm     7 GYVYDERMLGHECKYDSTMAECPK---RMKLIYERLQKDKLLDGAVKIDAREANDSEIRLNHPQ- 67

  Fly   904 HAMLFGSNQCQLSRPKLENTLSASFVRLSCGGLGVDLDTTWNEHHTATAARMAAGCVIDLALKTA 968
                      ||    ::..:|.:... .|.....|.:..|...:|..|||:|.|..|:|.....
Worm    68 ----------QL----IDEIVSLNSTE-KCEEYCKDKEILWTCENTNEAARVAIGGSIELVKAAM 117

  Fly   969 KGDLRNGFAVVRPPGHHAEANLAMGFCFFNSIAIAAKLLRQRMPEVRRILIVDWDVHHGNGTQQA 1033
            :|.:.||||:|||||||:...:|.|:|.||::|||||...::: ||:::.|||:|.|.||||.|:
Worm   118 EGKIHNGFAMVRPPGHHSYGKVAQGYCIFNNVAIAAKYAIEKL-EVKKVAIVDFDYHAGNGTYQS 181

  Fly  1034 FYQSPDILYLSIHRHDDGNFFPGTGGPTECGSGAGLGFNVNISWSGALNPPLGDAEYIAAFRTVV 1098
            ......|...|.|.|..|.|:|.:.......:.....|   :..:|.:|   .:.:|::.|..|:
Worm   182 VKDESRIHLTSFHGHHFGAFWPFSRDYDYATNSQNTLF---VPLNGTMN---SEGDYVSVFHHVL 240

  Fly  1099 MPIARSFNPDIVLVSSGFDAATGHPAPLGGYH---------VSPACFGFMTRELLQLANGKVVLA 1154
            :|:...|.|:::|:|:|||:         ||:         |....:|.|.|.|.|:..||::..
Worm   241 LPMLEQFQPELILISAGFDS---------GYYDVMMEFGQGVKAHGYGHMARLLSQICPGKILAI 296

  Fly  1155 LEGGYDLAAICDSAQECVRALLGDPAAPIAKAELERPPCQNAINTLQKTIAIQQTHWPCVRMLEH 1219
            |||||......:||...||.||..|        |.|......|:.     |:.:|.|   .:|.|
Worm   297 LEGGYHPYNYTESASMMVRGLLNLP--------LPRLDIPERISG-----ALLETTW---NILNH 345

  Fly  1220 ------TVGLSALETLK-VEHDESETINAMAGLSMQSMHRTLSRDDSEEPMDQDETK 1269
                  .:|    |.|| :||.:.|     .||...:..:|:...:....|..|..|
Worm   346 HSEWYPKLG----ERLKLLEHQQKE-----LGLPQFAFDQTMFLGEKMRKMYDDMKK 393

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HDAC4	NP_001259507.1	iSH2_PI3K_IA_R	43..>87	CDD:304922
HDAC4	NP_001259507.1	HDAC_classIIa	837..1211	CDD:212544	114/380 (30%)
hda-5	NP_741051.1	HDAC10_HDAC6-dom1	19..350	CDD:212526	111/381 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0123
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1484694at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820