DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HDAC4 and Hdac10

DIOPT Version :9

Sequence 1:	NP_001259507.1	Gene:	HDAC4 / 32278	FlyBaseID:	FBgn0041210	Length:	1269	Species:	Drosophila melanogaster
Sequence 2:	XP_006520600.1	Gene:	Hdac10 / 170787	MGIID:	2158340	Length:	667	Species:	Mus musculus

Alignment Length:	375	Identity:	138/375 - (36%)
Similarity:	200/375 - (53%)	Gaps:	25/375 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   839 TGLAYDPLMLKHSCICGDNAQHPEHSGRLQSVWARLNETDLVKRCDRLRARKATQEELQTVHTEA 903
            |.|.|...|.....:..|.....|...||.:....|.:..|.:||..|.|.:|::|||..||:..
Mouse     3 TALVYHEDMTATRLLWDDPECEIECPERLTAALDGLRQRGLEERCLCLSACEASEEELGLVHSPE 67

  Fly   904 HAMLFGSNQCQLSRPKLENTLSASFVRLSCGGLGVDLDTTWNEHHTATAARMAAGCVIDLALKTA 968
            :..|....| .|.:.:| :.||..:            :..:....|...||:|||..:.|.....
Mouse    68 YIALVQKTQ-TLDKEEL-HALSKQY------------NAVYFHPDTFHCARLAAGAALQLVDAVL 118

  Fly   969 KGDLRNGFAVVRPPGHHAEANLAMGFCFFNSIAIAAKLLRQRMPEVRRILIVDWDVHHGNGTQQA 1033
            .|.:.||.|:|||||||::...|.|||.||::|:|||..:|:. .::||||||||||||.|.|..
Mouse   119 TGAVHNGLALVRPPGHHSQRAAANGFCVFNNVALAAKHAKQKY-GLQRILIVDWDVHHGQGIQYI 182

  Fly  1034 FYQSPDILYLSIHRHDDGNFFP--GTGGPTECGSGAGLGFNVNISWSGALNPPLGDAEYIAAFRT 1096
            |...|.:||.|.||::.|:|:|  ........|.|.|.||.||:.|:   ...:|:|:|:|||..
Mouse   183 FNDDPSVLYFSWHRYEHGSFWPFLPESDADAVGQGQGQGFTVNLPWN---QVGMGNADYLAAFLH 244

  Fly  1097 VVMPIARSFNPDIVLVSSGFDAATGHPAPLGGYHVSPACFGFMTRELLQLANGKVVLALEGGYDL 1161
            |::|:|..|:|::||||:|||:|.|.|.  |....:|.||..:|:.|..||.|::...|||||.|
Mouse   245 VLLPLAFEFDPELVLVSAGFDSAIGDPE--GQMQATPECFAHLTQLLQVLAGGRICAVLEGGYHL 307

  Fly  1162 AAICDSAQECVRALLGDPAAPIAKAELERPPCQNAINTLQKTIAIQQTHW 1211
            .::..|....|:.|||||..|:....:   |||:|:.::|.....|..:|
Mouse   308 ESLAQSVCMMVQTLLGDPTPPLLGLMV---PCQSALESIQSVQTAQTPYW 354

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HDAC4	NP_001259507.1	iSH2_PI3K_IA_R	43..>87	CDD:304922
HDAC4	NP_001259507.1	HDAC_classIIa	837..1211	CDD:212544	137/373 (37%)
Hdac10	XP_006520600.1	Arginase_HDAC	18..354	CDD:388375	133/358 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0123
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1484694at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2991
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.850