DRSC/TRiP Functional Genomics Resources

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Protein Alignment HDAC4 and Hdac6

DIOPT Version :9

Sequence 1:NP_001259507.1 Gene:HDAC4 / 32278 FlyBaseID:FBgn0041210 Length:1269 Species:Drosophila melanogaster
Sequence 2:NP_001123888.1 Gene:Hdac6 / 15185 MGIID:1333752 Length:1149 Species:Mus musculus


Alignment Length:737 Identity:211/737 - (28%)
Similarity:304/737 - (41%) Gaps:206/737 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   534 HGHGS---------------HAHPH----PHAH-------GHGHGHGHGIYAGHQHNVP-----I 567
            ||.|:               |.:.|    ||..       |.|.|.|:.|      |||     :
Mouse   255 HGQGTQFIFDQDPSVLYFSIHRYEHGRFWPHLKASNWSTIGFGQGQGYTI------NVPWNQTGM 313

  Fly   568 TDAQVAQVHLH----------------KQGHRPL---GRTQSAPLPLGHPMLTGAVQLNVVQTHY 613
            .||......||                ..|...|   .:.:.|..|.|...||            
Mouse   314 RDADYIAAFLHILLPVASEFQPQLVLVAAGFDALHGDPKGEMAATPAGFAHLT------------ 366

  Fly   614 ENSEAERQAYEHQVVNQKVRQTVLTRSGAAAAAAAAAGVSVVREAQLKEEDDDSAAEVMDLTDKK 678
                       |.::.....:.:|:..|.....|.|.|||......|.:                
Mouse   367 -----------HLLMGLAGGKLILSLEGGYNLRALAKGVSASLHTLLGD---------------- 404

  Fly   679 KPPKTVLTSTIATSTSQNLPEALAAAAAAAAYRAPHNASSNSASATKSGIKLRDQEYLQQQREQL 743
              |..:|.|.:..          .|:|..:.|                 ..|...|...:..|:.
Mouse   405 --PCPMLESCVVP----------CASAQTSIY-----------------CTLEALEPFWEVLERS 440

  Fly   744 LLLQQEEELAKSLMRPLSRTLSSPLVPLGPHGLSQIPDTGQQPAPIATSSSADHIPPVNLSLPHR 808
            :..|:|:|:.::::.                  .:..:.|.:    ||:...|       :.|..
Mouse   441 VETQEEDEVEEAVLE------------------EEEEEGGWE----ATALPMD-------TWPLL 476

  Fly   809 QHRQLMSTLYASQLRNHQPSASGSPPHKVTTGLAYDPLMLKHSCICGDNAQHPEHSGRLQSVWAR 873
            |:|                           |||.||..|:.| |...|| .|||...|:..:...
Mouse   477 QNR---------------------------TGLVYDEKMMSH-CNLWDN-HHPETPQRILRIMCH 512

  Fly   874 LNETDLVKRCDRLRARKATQEELQTVHTEAHAMLFGSNQCQLSRPKLENTLSASFVRLSCGGLGV 938
            |.|..|..||..|.||.|...||.|.|:..:.....:.:...:|.....              |.
Mouse   513 LEEVGLAARCLILPARPALDSELLTCHSAEYVEHLRTTEKMKTRDLHRE--------------GA 563

  Fly   939 DLDTTWNEHHTATAARMAAGCVIDLALKTAKGDLRNGFAVVRPPGHHAEANLAMGFCFFNSIAIA 1003
            :.|:.:....|...|::|.|....|......|::.||.|||||||||||.|.|.|||||||:|:|
Mouse   564 NFDSIYICPSTFACAKLATGAACRLVEAVLSGEVLNGIAVVRPPGHHAEPNAACGFCFFNSVAVA 628

  Fly  1004 AKLLRQRMPEVRRILIVDWDVHHGNGTQQAFYQSPDILYLSIHRHDDGNFFP--GTGGPTECGSG 1066
            |:..:.......||||||||||||||||..|...|.:||:|:||:|.|.|||  ..|..::.|..
Mouse   629 ARHAQIIAGRALRILIVDWDVHHGNGTQHIFEDDPSVLYVSLHRYDRGTFFPMGDEGASSQVGRD 693

  Fly  1067 AGLGFNVNISWSGALNPPLGDAEYIAAFRTVVMPIARSFNPDIVLVSSGFDAATGHPAPLGGYHV 1131
            ||:||.||:.|:|   |.:|||:|:||:..:|:|||..|||::||:|:|||||.|.  ||||..|
Mouse   694 AGIGFTVNVPWNG---PRMGDADYLAAWHRLVLPIAYEFNPELVLISAGFDAAQGD--PLGGCQV 753

  Fly  1132 SPACFGFMTRELLQLANGKVVLALEGGYDLAAICDSAQECVRALLGDPAAPIAKAELERPPCQNA 1196
            :|..:..:|..|:.||.|:::|.|||||:||:|.:|...|..:|||||...:.   |.|||...|
Mouse   754 TPEGYAHLTHLLMGLAGGRIILILEGGYNLASISESMAACTHSLLGDPPPQLT---LLRPPQSGA 815

  Fly  1197 INTLQKTIAIQQTHWPCVRMLE 1218
            :.::.:.|.:.:.:|..:|:::
Mouse   816 LVSISEVIQVHRKYWRSLRLMK 837

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HDAC4NP_001259507.1 iSH2_PI3K_IA_R 43..>87 CDD:304922
HDAC_classIIa 837..1211 CDD:212544 155/375 (41%)
Hdac6NP_001123888.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..61
Histone deacetylase 1 87..403 34/176 (19%)
Arginase_HDAC 98..434 CDD:418394 43/252 (17%)
Histone deacetylase 2 481..799 144/338 (43%)
HDAC6-dom2 484..834 CDD:212527 153/373 (41%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 954..975
zf-UBP 1067..1129 CDD:396634
Ubiquitin binding. /evidence=ECO:0000250|UniProtKB:Q9UBN7 1088..1090
Ubiquitin binding. /evidence=ECO:0000250|UniProtKB:Q9UBN7 1116..1123
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0123
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1484694at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100220
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2991
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
65.750

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