DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HDAC4 and AgaP_AGAP006511

DIOPT Version :9

Sequence 1:	NP_001259507.1	Gene:	HDAC4 / 32278	FlyBaseID:	FBgn0041210	Length:	1269	Species:	Drosophila melanogaster
Sequence 2:	XP_316539.2	Gene:	AgaP_AGAP006511 / 1277106	VectorBaseID:	AGAP006511	Length:	470	Species:	Anopheles gambiae

Alignment Length:	440	Identity:	104/440 - (23%)
Similarity:	177/440 - (40%)	Gaps:	96/440 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   860 HPEHSGRLQSVWARLNETDLVKRCDRLRARKATQEELQTVHTEAHAMLFGSNQCQLSRPKLENTL 924
            ||....|::.....|....|.::.:..|..|||.:|:...|::.:.....|     .||...:..
Mosquito    26 HPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATADEMTKFHSDDYIRFLRS-----IRPDNMSEY 85

  Fly   925 SASFVRLSCGGLGVDLDTTWNEHHTATAARMAAGCVIDLALKTAK----------GDLRNGFAVV 979
            :....|.:.|......|..:.      ..:::||..:..|:|..|          |.|
Mosquito    86 NKHMQRFNVGEDCPVFDGLYE------FCQLSAGGSVAAAVKLNKQASEICINWGGGL------- 137

  Fly   980 RPPGHHAEANLAMGFCFFNSIAIA-AKLLRQRMPEVRRILIVDWDVHHGNGTQQAFYQSPDILYL 1043
                |||:.:.|.|||:.|.|.:. .:||:..    :|:|.:|.|||||:|.::|||.:..::.:
Mosquito   138 ----HHAKKSEASGFCYVNDIVLGILELLKYH----QRVLYIDIDVHHGDGVEEAFYTTDRVMTV 194

  Fly  1044 SIHRHDDGNFFPGTGGPTECGSGAGLGFNVNISWSGALNPPLGDAEYIAAFRTVVMPIARSFNPD 1108
            |.|::  |.:|||||...:.|:|.|..:.|||    .|...:.|..|.:.|..::..:..:|.|.
Mosquito   195 SFHKY--GEYFPGTGDLRDIGAGRGKYYAVNI----PLRDGMDDESYDSIFVPIISKVMETFQPS 253

  Fly  1109 IVLVSSGFDAATGHPAPLGGYHVSPACFGFMTR------ELLQLANGKVVLALEGGYDLAAI--C 1165
            .|::..|.|:.||.  .||       ||....:      |.::..|...::...|||.:..:  |
Mosquito   254 AVVLQCGADSLTGD--RLG-------CFNLTVKGHGKCVEFVKKYNLPFLMVGGGGYTIRNVSRC 309

  Fly  1166 DSAQECVRALLGDPAA-------------PIAKAELERPPCQNAINTLQKTIAIQQTHWPCVRML 1217
            .:.:..|  .||...|             |..|..:. |...:..||.:....|:...:..:|||
Mosquito   310 WTYETSV--ALGVEIANELPYNDYFEYFGPDFKLHIS-PSNMSNQNTTEYLEKIKNRLFENLRML 371

  Fly  1218 EHTVGLSALETLKVEHDESETINAMAGLSMQSMHRTLSRDDSEEPMDQDE 1267
            .|..|      ::|:....:.||              ...:.|:.:|:||
Mosquito   372 PHAPG------VQVQPIPEDAIN--------------DESEDEDKVDKDE 401

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HDAC4	NP_001259507.1	iSH2_PI3K_IA_R	43..>87	CDD:304922
HDAC4	NP_001259507.1	HDAC_classIIa	837..1211	CDD:212544	92/382 (24%)
AgaP_AGAP006511	XP_316539.2	Arginase_HDAC	5..372	CDD:302587	94/389 (24%)
AgaP_AGAP006511	XP_316539.2	PTZ00063	6..396	CDD:240251	101/433 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0123
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810