Protein Alignment HDAC4 and HDAC6

DIOPT Version :10

• Sequence 1: NP_001259507.1
• Gene: HDAC4 / 32278
• FlyBaseID: FBgn0041210
• Length: 1269
• Species: Drosophila melanogaster
• Sequence 2: XP_061502723.1
• Gene: HDAC6 / 1271709
• VectorBaseID: AGAMI1_007942
• Length: 1114
• Species: Anopheles gambiae
• Alignment Length: 910
• Identity: 261/910 - (28%)
• Similarity: 369/910 - (40%)
• Gaps: 216/910 - (23%)

  Fly   453 PSPVVRSASATSTSSSQASLV----GDVAPPQAHAAST----ILPSSSSYMQQLGSVAGSGVNL- 508
            |.|..|:...|..::.|..|:    |....|:....|:    |....:||...:.:| ||.:.|
Mosquito   149 PRPATRAELLTKHTAEQIELLAQMHGSQDEPELERLSSHYDAIFIHPTSYETSVLAV-GSTIQLV 212

  Fly   509 -------------------HAAAVA----------AAAAAAAAAGSLPPTN--------SHGHGH 536
                               |.|..|          .|.||..|...|....        .||.|.
Mosquito   213 ESVWSGTVQNGMAILRPPGHHAMTAEYNGYCFFNNVAIAAQHALDHLGTQKILIVDWDVHHGQGT 277

  Fly   537 GSHAHPHP-------HAHGHGH-------------GHGHGIYAGHQHNVPITDAQVAQVHLHKQG 581
            ....:..|       |.:.||.             |.|.|  .|:..|||:...
Mosquito   278 QRMFYSDPRVLYFSIHRYEHGTFWPNLRESDFDYVGTGKG--EGYNFNVPLNKT----------- 329

  Fly   582 HRPLGRTQSAPLPLGHPMLTGAV-----QLNVVQTHYENS--------EAERQAYEHQVVNQKVR 633
                |.|....|.:...:|....     :|.:|...|:.:        |.....|.|      :.
Mosquito   330 ----GMTNGDYLAIWQQLLLPVATEFQPELIIVSAGYDAAYGCPEGCMEITPAFYSH------LL 384

  Fly   634 QTVLTRSGAAAAAAAAAGVSVVREAQLKEEDDDSAAEVMDLTDKKKPPKTVLTSTIATSTSQNLP 698
            ..:|..:....|.....|..:           :|.||...||.|          |:....:..|.
Mosquito   385 SPLLLMAQGRVAVVLEGGYCL-----------ESLAEGCALTLK----------TLLGDPAPRLA 428

  Fly   699 EALAAAAAAAAYRAPHNASSNSASATKSGIKLRDQEYLQQQREQLLLLQQEEELAKSLMRPLSRT 763
            |||             ...|.|..|:........::|.:..  ||..|...|:...:..:.....
Mosquito   429 EAL-------------QPPSESMQASILNCIYSHRKYWKCL--QLYELYDLEDYNNTNPQDNFHK 478

  Fly   764 LSSPLVPLGPHGLSQIPDTGQQPAPIATSS-----SADHIPPVNLSLPHRQHRQLMSTLYASQLR 823
            :....||         |:...||....|.:     |||            |..::...|    .|
Mosquito   479 VIKCYVP---------PEPPAQPGRYETRNCYPVQSAD------------QRARIQDRL----AR 518

  Fly   824 NHQPSASGSPPHKVTTGLAYDPLMLKHSCICGDNAQ--HPEHSGRLQSVWARL-NETDLVKRCDR 885
            .|..:....||.:|.  ..||.|||:|.    ::|:  |||...|:..:..|| .:..|.:|..|
Mosquito   519 LHLATDLSFPPDRVC--YVYDELMLEHR----NSAEKWHPEQPERIAKIMQRLTGDYQLAQRMKR 577

  Fly   886 LRARKATQEELQTVHTEAHAMLFGSNQCQLSRPKLENTLSASFVRLSCGGLGVDLDTTWNEHHTA 950
            |..|.||.|||..||...|..|.| ..||.|  .::.|..             ..::.:....|.
Mosquito   578 LPGRLATTEELCLVHGPEHVRLIG-EVCQSS--TMKQTAD-------------QYNSIYFHPSTD 626

  Fly   951 TAARMAAGCVIDLALKTAKGDLRNGFAVVRPPGHHAEANLAMGFCFFNSIAIAAKLLRQRMPEVR 1015
            .:||||.|.|:.:.....:|..|:|..|||||||||||:...|||.:||||:||:...:|. .:|
Mosquito   627 ASARMATGSVLTVVEDVLEGRTRSGVCVVRPPGHHAEADTPHGFCIYNSIAVAARHAVKRY-GLR 690

  Fly  1016 RILIVDWDVHHGNGTQQAFYQSPDILYLSIHRHDDGNFFPGT--GGPTECGSGAGLGFNVNISWS 1078
            |:||||||||||||||..|.|.|.:||:|:||:|:|.|||.:  ...|..|||.|.||||||.|:
Mosquito   691 RVLIVDWDVHHGNGTQHIFEQDPHVLYVSVHRYDNGAFFPRSTDADYTVVGSGPGRGFNVNIPWN 755

  Fly  1079 GALNPPLGDAEYIAAFRTVVMPIARSFNPDIVLVSSGFDAATGHPAPLGGYHVSPACFGFMTREL 1143
               ...:||.||:|||.:|::|||..:.|::||||:|||||.|.  ||||..|:|..:|..|:.|
Mosquito   756 ---RKGMGDPEYVAAFHSVILPIAYEYEPELVLVSAGFDAAIGD--PLGGCRVTPEAYGHFTQWL 815

  Fly  1144 LQLANGKVVLALEGGYDLAAICDSAQECVRALLGDP---AAPIAKAELERPPCQNA--INTLQKT 1203
            ..||.|::||.|||||::.:|..:...|.:||||||   ..|:: .....||..:|  ..||...
Mosquito   816 SVLAGGRLVLCLEGGYNVNSISHAMAMCAKALLGDPLPMLLPVS-GTARTPPATHASCCETLSNV 879

  Fly  1204 IAIQQTHWPCVRMLEHTVGLSALETLKVEHDESETINAMAGLSMQSMHRTLSRDDSEEPMDQDET 1268
            :::|:.:|   |.|.....|.:.|.| :|...||.|.|:..:::.....|    |.::|.....|
Mosquito   880 LSVQRLYW---RSLCFNKKLPSSEPL-LEEAGSELIEALDNMTLSERGGT----DQQQPQQTTST 936

  Fly  1269  1268
            Mosquito   937  936

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HDAC4	NP_001259507.1	ClassIIa_HDAC_Gln-rich-N	43..>87	CDD:421006
		HDAC_classIIa	837..1211	CDD:212544	161/383 (42%)
HDAC6	XP_061502723.1	None