DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HDAC4 and AgaP_AGAP000532

DIOPT Version :9

Sequence 1:	NP_001259507.1	Gene:	HDAC4 / 32278	FlyBaseID:	FBgn0041210	Length:	1269	Species:	Drosophila melanogaster
Sequence 2:	XP_003437019.1	Gene:	AgaP_AGAP000532 / 1271709	VectorBaseID:	AGAP000532	Length:	1118	Species:	Anopheles gambiae

Alignment Length:	907	Identity:	263/907 - (28%)
Similarity:	374/907 - (41%)	Gaps:	211/907 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   453 PSPVVRSASATSTSSSQASLV----GDVAPPQAHAAST----ILPSSSSYMQQLGSVAGSGVNL- 508
            |.|..|:...|..::.|..|:    |....|:....|:    |....:||...:.:| ||.:.|
Mosquito   154 PRPATRAELLTKHTAEQIELLAQTHGSQDEPELERLSSHYDAIFIHPTSYETSVLAV-GSTIQLV 217

  Fly   509 -------------------HAAAVA----------AAAAAAAAAGSLPPTN--------SHGHGH 536
                               |.|..|          .|.||..|...|....        .||.|.
Mosquito   218 ESVWSGTVQNGMAILRPPGHHAMTAEYNGYCFFNNVAIAAQHALDHLGTQKILIVDWDVHHGQGT 282

  Fly   537 GSHAHPHP-------HAHGHGH-------------GHGHGIYAGHQHNVPITDAQVAQVHLHKQG 581
            ....:..|       |.:.||.             |.|.|  .|:..|||          |:|.|
Mosquito   283 QRMFYSDPRVLYFSIHRYEHGTFWPNLRESDFDYVGTGKG--EGYNFNVP----------LNKTG 335

  Fly   582 HRP---LGRTQSAPLPLGHPMLTGAVQLNVVQTHYENSEAERQA-------YEHQVVNQKVRQTV 636
            ...   |...|...||:....   |.:|.:|...|:::..:.:.       |.|      :...:
Mosquito   336 MTNGDYLAIWQQLLLPVATEF---APELIIVSAGYDSALGDEKGCMETPAFYSH------LLSPL 391

  Fly   637 LTRSGAAAAAAAAAGVSVVREAQLKEEDDDSAAEVMDLTDKKKPPKTVLTSTIATSTSQNLPEAL 701
            |..:....|.....|..:           :|.||...||.|          |:....:..|.|||
Mosquito   392 LLMAQGRVAVVLEGGYCL-----------ESLAEGCALTLK----------TLLGDPAPRLAEAL 435

  Fly   702 AAAAAAAAYRAPHNASSNSASATKSGIKLRDQEYLQQQREQLLLLQQEEELAKSLMRPLSRTLSS 766
                         ...|.|..|:........::|.:..  ||..|...|:...:..:.....:..
Mosquito   436 -------------QPPSESMQASILNCIYSHRKYWKCL--QLYELYDLEDYNNTNPQDNFHKVIK 485

  Fly   767 PLVPLGPHGLSQIPDTGQQPAPIATSS-----SADHIPPVNLSLPHRQHRQLMSTLYASQLRNHQ 826
            ..||         |:...||....|.:     |||            :..::...|    .|.|.
Mosquito   486 CYVP---------PEPPAQPGRYETRNCYPVQSAD------------ERARIQDRL----ARLHL 525

  Fly   827 PSASGSPPHKVTTGLAYDPLMLKHSCICGDNAQ--HPEHSGRLQSVWARL-NETDLVKRCDRLRA 888
            .:....||.:|.  ..||.|||:|.    ::|:  |||...|:..:..|| .:..|.:|..||..
Mosquito   526 ATDLSFPPDRVC--YVYDELMLEHR----NSAEKWHPEQPERIAKIMQRLTGDYQLAQRMKRLPG 584

  Fly   889 RKATQEELQTVHTEAHAMLFGSNQCQLSRPKLENTLSASFVRLSCGGLGVDLDTTWNEHHTATAA 953
            |.||.|||..||...|..|.| ..||.|  .::.|..             ..::.:....|..:|
Mosquito   585 RLATTEELCLVHGPEHVRLIG-EVCQSS--TMKQTAD-------------QYNSIYFHPSTDASA 633

  Fly   954 RMAAGCVIDLALKTAKGDLRNGFAVVRPPGHHAEANLAMGFCFFNSIAIAAKLLRQRMPEVRRIL 1018
            |||.|.|:.:.....:|..|:|..|||||||||||:...|||.:||||:||:...:|. .:||:|
Mosquito   634 RMATGSVLTVVEDVLEGRTRSGVCVVRPPGHHAEADTPHGFCIYNSIAVAARHAVKRY-GLRRVL 697

  Fly  1019 IVDWDVHHGNGTQQAFYQSPDILYLSIHRHDDGNFFPGT--GGPTECGSGAGLGFNVNISWSGAL 1081
            |||||||||||||..|.|.|.:||:|:||:|:|.|||.:  ...|..|||.|.||||||.|:
Mosquito   698 IVDWDVHHGNGTQHIFEQDPHVLYVSVHRYDNGAFFPRSTDADYTVVGSGPGRGFNVNIPWN--- 759

  Fly  1082 NPPLGDAEYIAAFRTVVMPIARSFNPDIVLVSSGFDAATGHPAPLGGYHVSPACFGFMTRELLQL 1146
            ...:||.||:|||.:|::|||..:.|::||||:|||||.|.  ||||..|:|..:|..|:.|..|
Mosquito   760 RKGMGDPEYVAAFHSVILPIAYEYEPELVLVSAGFDAAIGD--PLGGCRVTPEAYGHFTQWLSVL 822

  Fly  1147 ANGKVVLALEGGYDLAAICDSAQECVRALLGDP---AAPIAKAELERPPCQNA--INTLQKTIAI 1206
            |.|::||.|||||::.:|..:...|.:||||||   ..|:: .....||..:|  ..||...:::
Mosquito   823 AGGRLVLCLEGGYNVNSISHAMAMCAKALLGDPLPMLLPVS-GTARTPPATHASCCETLSNVLSV 886

  Fly  1207 QQTHWPCVRMLEHTVGLSALETLKVEHDESETINAMAGLSMQSMHRTLSRDDSEEPMDQDET 1268
            |:.:|   |.|.....|.:.|.| :|...||.|.|:..:::.....|    |.::|.....|
Mosquito   887 QRLYW---RSLCFNKKLPSSEPL-LEETGSELIEALDNMTLSERGGT----DQQQPQQTTST 940

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HDAC4	NP_001259507.1	iSH2_PI3K_IA_R	43..>87	CDD:304922
HDAC4	NP_001259507.1	HDAC_classIIa	837..1211	CDD:212544	161/383 (42%)
AgaP_AGAP000532	XP_003437019.1	HDAC10_HDAC6-dom1	120..457	CDD:212526	68/358 (19%)
		Arginase_HDAC	540..894	CDD:302587	162/383 (42%)
		zf-UBP	1015..1078	CDD:280334
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D14578at50557
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920