DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HDAC4 and Hdac6

DIOPT Version :9

Sequence 1:	NP_001259507.1	Gene:	HDAC4 / 32278	FlyBaseID:	FBgn0041210	Length:	1269	Species:	Drosophila melanogaster
Sequence 2:	XP_003752058.1	Gene:	Hdac6 / 108348065	RGDID:	619981	Length:	1152	Species:	Rattus norvegicus

Alignment Length:	536	Identity:	178/536 - (33%)
Similarity:	261/536 - (48%)	Gaps:	63/536 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   707 AAAYRAPHNASSNSASATKSGIKLRDQEYLQQQREQLLLLQQE-----EELAKSLMRPLSRTLSS 766
            ||.:.|.|.......|||.:|. .....:|.......|:|..|     ..|||.:...|...|..
  Rat   341 AAGFDALHGDPKGEMSATPAGF-AHLTHFLMGLAGGKLILSLEGGYNLHALAKGVSGSLHTLLGD 404

  Fly   767 PLVPLGPHGLSQIPDTGQQPAPIATSSSA--------DHIPP----VNLSLPHRQHRQLMSTLYA 819
            |...|              .:|:|..:||        :.:.|    :..|:..:...::...:..
  Rat   405 PCPML--------------ESPVAPCASAQTSISCTLEALEPFWEVLERSVEPQDEDEVEGDMLE 455

  Fly   820 SQLRNHQPSASGSPPH-----KVTTGLAYDPLMLKHSCICGDNAQHPEHSGRLQSVWARLNETDL 879
            .:.......|:..|..     :..|||.||..|:.| |...|| .|||...|:..:...|.|..|
  Rat   456 DEEEEGHWEATALPMDTWPLLQNRTGLVYDERMMSH-CNLWDN-HHPETPQRILRIMCHLEEVGL 518

  Fly   880 VKRCDRLRARKATQEELQTVHTEAHAMLFGSNQCQLSRPKLENTLSASFVRLSCGGLGVDLDTTW 944
            ..||..|.||.|...||.|.|:..:.....:.:...:|.....              |.:.::.:
  Rat   519 AARCLILPARPALDSELLTCHSAEYVERLRATEKMKTRDLHRE--------------GANFESIY 569

  Fly   945 NEHHTATAARMAAGCVIDLALKTAKGDLRNGFAVVRPPGHHAEANLAMGFCFFNSIAIAAKLLRQ 1009
            ....|...|::|.|....|......|::.||.|:|||||||||.:.|.|||||||:|:||:..:.
  Rat   570 ICPSTFACAQLATGAACRLVEAVLSGEVLNGIAIVRPPGHHAEPDAACGFCFFNSVAVAARHAQV 634

  Fly  1010 RMPEVRRILIVDWDVHHGNGTQQAFYQSPDILYLSIHRHDDGNFFP--GTGGPTECGSGAGLGFN 1072
            ......||||||||||||||||..|.:.|.:||:|:||:|.|.|||  ..|..::.|..||.||.
  Rat   635 IAGRALRILIVDWDVHHGNGTQHIFEEDPSVLYVSLHRYDRGTFFPMGDEGASSQVGRAAGTGFT 699

  Fly  1073 VNISWSGALNPPLGDAEYIAAFRTVVMPIARSFNPDIVLVSSGFDAATGHPAPLGGYHVSPACFG 1137
            ||:.|:|   |.:|||:|:|.:..:|:|||..|||::||:|:|||||.|.  ||||..|:|..:.
  Rat   700 VNVPWNG---PRMGDADYLATWHRLVLPIAYEFNPELVLISAGFDAAQGD--PLGGCQVTPEGYA 759

  Fly  1138 FMTRELLQLANGKVVLALEGGYDLAAICDSAQECVRALLGDPAAPIAKAELERPPCQNAINTLQK 1202
            .:|..|:.||.|:::|.|||||:|.:|.:|...|..:|||||...:...   |||...|:.::.:
  Rat   760 HLTHLLMGLAGGRIILILEGGYNLTSISESMAACTHSLLGDPPPQLTSL---RPPQSGALASISE 821

  Fly  1203 TIAIQQTHWPCVRMLE 1218
            .|.:.:.:|..:|:::
  Rat   822 VIQVHRKYWRSLRLMK 837

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HDAC4	NP_001259507.1	iSH2_PI3K_IA_R	43..>87	CDD:304922
HDAC4	NP_001259507.1	HDAC_classIIa	837..1211	CDD:212544	149/375 (40%)
Hdac6	XP_003752058.1	Arginase_HDAC	98..434	CDD:418394	24/107 (22%)
		HDAC6-dom2	484..834	CDD:212527	147/373 (39%)
		zf-UBP	1070..1132	CDD:396634
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0123
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1484694at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910