DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HDAC4 and hdac10

DIOPT Version :9

Sequence 1:	NP_001259507.1	Gene:	HDAC4 / 32278	FlyBaseID:	FBgn0041210	Length:	1269	Species:	Drosophila melanogaster
Sequence 2:	XP_002932227.1	Gene:	hdac10 / 100497245	XenbaseID:	XB-GENE-5857298	Length:	671	Species:	Xenopus tropicalis

Alignment Length:	434	Identity:	149/434 - (34%)
Similarity:	226/434 - (52%)	Gaps:	50/434 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   829 ASGSPPHKVTTGLAYDPLMLKHSCICGDNAQHPEHSGRLQSVWARLNETDLVKRCDRLRARKATQ 893
            |||       |.|.||..|:.:..:..|.....|...||.|.:.||.:.||||||.:|..|:||.
Frog     2 ASG-------TALVYDEEMMSYKLLWDDQECSIEVPERLSSSYKRLQDYDLVKRCTQLPVREATD 59

  Fly   894 EELQTVHTEAHAMLFGSNQCQLSRPKLENTLSASFVRLSCGGLGVDLDTTWNEHHTATAARMAAG 958
            ||:..||:..:..:..|.| .::..:||. :|..:.            ..:...::...|:::.|
Frog    60 EEITLVHSSDYLEVVKSTQ-TMNEKELEE-ISRKYT------------AVFFHQNSFRCAKLSLG 110

  Fly   959 CVIDLALKTAKGDLRNGFAVVRPPGHHAEANLAMGFCFFNSIAIAAKLLRQRMPEVRRILIVDWD 1023
            ..:.|......|:::||.|:|||||||::.:...|||.||::||||:..:::. ::.||||||||
Frog   111 GTLQLVDAVLSGEVQNGMALVRPPGHHSQRDQGNGFCVFNNVAIAAEYAKKKY-KLERILIVDWD 174

  Fly  1024 VHHGNGTQQAFYQSPDILYLSIHRHDDGNFFP--GTGGPTECGSGAGLGFNVNISWSGALNPPLG 1086
            ||||.|.|..|.:.|.:||.|.||::...|:|  ........|.|.|.|||:|:.|:   ...:.
Frog   175 VHHGQGIQYIFEEDPSVLYFSWHRYEHKTFWPYLSESDYNAVGRGKGTGFNINLPWN---KVGMS 236

  Fly  1087 DAEYIAAFRTVVMPIARSFNPDIVLVSSGFDAATGHPAPLGGYHVSPACFGFMTRELLQLANGKV 1151
            :|:|||.|..|::|:|..|||::||||:|:|:|.|.|.  |....:|.||..:|..|:.||:||:
Frog   237 NADYIAVFFHVLLPLAFEFNPELVLVSAGYDSAIGDPE--GRMCATPECFSHLTSMLMNLADGKL 299

  Fly  1152 VLALEGGYDLAAICDSAQECVRALLGDPAAPIAKAELERPPCQNAINTLQKTIAIQQTHWPCVRM 1216
            ...|||||:|.::.:|....||.||||   |:.|...|..||.:|:.::|...|....:|.|
Frog   300 CAVLEGGYNLRSLAESVCMTVRTLLGD---PLPKLTGEMTPCHSALESIQNVRAAHSPYWKC--- 358

  Fly  1217 LEHTVGLSALETLKVEHDESETINAMAGLSMQSMHRTLSRDDSE 1260
                  |.....|:..||..         |.:::...||.|..:
Frog   359 ------LLCDGNLRSAHDPG---------SKENLDSQLSSDQQQ 387

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HDAC4	NP_001259507.1	iSH2_PI3K_IA_R	43..>87	CDD:304922
HDAC4	NP_001259507.1	HDAC_classIIa	837..1211	CDD:212544	136/375 (36%)
hdac10	XP_002932227.1	HDAC10	20..356	CDD:212546	131/358 (37%)
hdac10	XP_002932227.1	Arginase_HDAC	<538..633	CDD:418394
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1484694at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010