DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HDAC4 and hdac9

DIOPT Version :9

Sequence 1:	NP_001259507.1	Gene:	HDAC4 / 32278	FlyBaseID:	FBgn0041210	Length:	1269	Species:	Drosophila melanogaster
Sequence 2:	XP_004915470.1	Gene:	hdac9 / 100493483	XenbaseID:	XB-GENE-488739	Length:	610	Species:	Xenopus tropicalis

Alignment Length:	734	Identity:	176/734 - (23%)
Similarity:	275/734 - (37%)	Gaps:	256/734 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 ITPATLTLDFK-PHPAVD-------IDQQIMELKKSQELQKQRLINSFQEQSKQMELEHKLQLEH 82
            |:|..|..|.: ..|.||       :.|:::.:|:.|::|||.||..||:|.:.:..:|:.||:.
Frog    48 ISPLDLRTDLRTAMPVVDPVLREKQLQQELLIIKQQQQIQKQLLIAEFQKQHENLTRQHQAQLQE 112

  Fly    83 KYQKQPTNKRFSLELIVIIQFAVNSHGAFQELRNESMVTAAAAAVAQEQHRQQLHQQQQQHQQQQ 147
            ..:.|.       ||:.:                              :|:|:|.:::::|:.:|
Frog   113 HLKLQQ-------ELLAM------------------------------KHQQELLEREKEHKMEQ 140

  Fly   148 QQ-----QQHQQQQQQQQARGRDGMKLKQNCSANASPEVKQILNCFILSRKSQAAASNGTTTTSP 207
            |:     ::|:::||....|.:|.:|.:    |.||.||||.|..||||
Frog   141 QRKEQEAERHRREQQLCHPRSKDRVKER----AVASTEVKQKLQEFILS---------------- 185

  Fly   208 YRNRGVVKSSSGESLPAGT-----------VTSAHPYKIPQ--PPPS---------LLKYESDFP 250
                   ||::.|||..|.           .|:||...:.|  ||||         |...:.|||
Frog   186 -------KSATKESLTNGASHSMGRHPKLWYTAAHHTSLDQSSPPPSGTSPTYKCPLPGNQDDFP 243

  Fly   251 LRKTASEPNL-LKIRLKQSVIERKARIGGPAGARRHERLLQAAQRR--QQKNSVLTNCNSTPDSG 312
            |||||||||| ::.||||.|:||::   .|...|:...:..:.::|  :...||   .:|:|.||
Frog   244 LRKTASEPNLKVRSRLKQKVVERRS---SPLLRRKDGNVTSSYKKRIFEVTESV---SSSSPVSG 302

  Fly   313 PNSPPSAAALAVGVVGSRGSPT-SAPIQEENEEGSQYQPGQRSSINDLPLFSSPSLPNISLGRPH 376
            |:||.:.   .|.:......|. ||..:.||.....:......|:|.|.|::|||||||::|
Frog   303 PSSPNNG---PVAMEAENEVPVLSANSRIENLVSHHHLVHHEKSLNLLNLYTSPSLPNITIG--- 361

  Fly   377 LPNSAQAHA---QVNAQVAAQAQAQAQAQAQAHAMFAALAAAQGGCGQPGYYNPLGMAFVGRQPA 438
                  .||   |:|...:.:.|.:...||....:..|           |.|
Frog   362 ------LHATATQLNTSSSLKEQQKYDPQAPRQGVSVA-----------GQY------------- 396

  Fly   439 PLAMIPATGIAPQQPSPVVRSASATSTSSSQASLVGDVAPPQAHAASTILPSSSSYMQQLGSVAG 503
                                 |....|||:..||.|............:|.......|::.:..|
Frog   397 ---------------------AGGIPTSSNHVSLEGKTNSSHQALLQHLLLKEQMRQQKILASGG 440

  Fly   504 SGVNLHAAAVAAAAAAAAAAGSLPPTNSHGHGHGSHAHPHPHAHGHGHGHGHGIYAGHQHNVPIT 568
            :.| ||.:.:.|....:.|              |..||..|.
Frog   441 TPV-LHQSPLPAKERVSPA--------------GRVAHKLPR----------------------- 467

  Fly   569 DAQVAQVHLHKQGHRPLGRTQSAPLPLGHPMLTGAVQLNVVQTHYENSEAERQAYEHQ-----VV 628
                         ||||.||||||||     .:...||.:.|.|.:..|.::| |:.|     ::
Frog   468 -------------HRPLHRTQSAPLP-----QSTLAQLVIQQQHQQFLEKQKQ-YQQQIHMNKIL 513

  Fly   629 NQKVRQTVLTRSGAAAAAAAAAGVSVVRE-----------------------AQLKEEDDDSAAE 670
            ::.:.|..........|.....|.:|::|                       .::|||..||..|
Frog   514 SKSIEQLRQPEGHLEEAEEDLHGDNVIQEKSSSADNTRSYSSTDLRTGHLGSVKVKEEPPDSEDE 578

  Fly   671 VMDLTDKKKPPKTVLTSTI 689
            :.  |..:...|.|....:
Frog   579 IK--THLQSEQKAVFVQQV 595

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HDAC4	NP_001259507.1	iSH2_PI3K_IA_R	43..>87	CDD:304922	14/43 (33%)
HDAC4	NP_001259507.1	HDAC_classIIa	837..1211	CDD:212544
hdac9	XP_004915470.1	ClassIIa_HDAC9_Gln-rich-N	65..156	CDD:197399	26/127 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	141	1.000	Domainoid score	I4670
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000