Protein Alignment HDAC4 and slc4a4

DIOPT Version :9

• Sequence 1: NP_001259507.1
• Gene: HDAC4 / 32278
• FlyBaseID: FBgn0041210
• Length: 1269
• Species: Drosophila melanogaster
• Sequence 2: XP_004919190.2
• Gene: slc4a4 / 100490445
• XenbaseID: XB-GENE-479125
• Length: 1128
• Species: Xenopus tropicalis
• Alignment Length: 583
• Identity: 114/583 - (19%)
• Similarity: 182/583 - (31%)
• Gaps: 175/583 - (30%)

  Fly   539 HAHPHPHAHGHGHGHGHGIYAGHQHNVPITDAQVAQVHLHKQGHRPLGRTQSAPLPLGHPMLTGA 603
            |........||     |.:|.|              ||:.|...|   |.:       |...||
 Frog    16 HVCDEEEVEGH-----HTVYIG--------------VHVPKSYRR---RRR-------HRHRTG- 50

  Fly   604 VQLNVVQTHYENSEAERQAYEHQVVNQKVRQTVLTRSGAAAAAAAAAGVSVVREAQLKEEDDDSA 668
                    |.|..|.|:.:..:..:::...:.....|.:......:.....:|  .:..|||||.
 Frog    51 --------HKEKKEKEKSSENYSDLDKSDTENADETSSSILKPLISPAAERIR--FILGEDDDSP 105

  Fly   669 AEVMDLTDKKKPPK--TVLTSTIAT--------STSQNLPEALAAAAAAAAYRAPHNASSNSAS- 722
            |          ||:  |.|...::.        .|::.|............:..||.|:.:..|
 Frog   106 A----------PPQLFTELDELLSVDGQEMEWKETARWLKFEEKVEQGGERWSKPHVATLSLHSL 160

  Fly   723 -----ATKSGIKLRDQE--YLQQQREQLLLLQQEEELAKS----------LMRPLSRTLSSPLVP 770
                 ..:.|..|.|.|  .|.|..|::|..|.|..|.|:          |.:...:|..|.|..
 Frog   161 FELRTCIEKGTILLDLEANSLPQVVEKILDNQIETGLLKAELKDKVTYTLLRKHRHQTKKSNLRS 225

  Fly   771 LGPHG--------LSQIPDTGQQPAPIATSSSADHIPPVNLSLPHRQHRQLMSTLYASQLRNHQP 827
            |...|        :...||.|.:...:..:|......|:..|:|          ..|:::.:...
 Frog   226 LADIGKTVSSASRMFTSPDNGVREEGLVKNSFLSARSPLETSVP----------CLATRMSDDDL 280

  Fly   828 SASGSPPHKVTTGLAYDPLMLKH---SCICGDNAQHPEHSGRLQSVWARLNETD------LVKRC 883
            ....||    :.||...|.|...   |....|.:..|: ..:|::.:.:....|      ||...
 Frog   281 RVRRSP----SMGLLSSPTMSPRNLTSSSLNDISDKPD-KDQLKNKFMKKIPRDAEASNVLVGEV 340

  Fly   884 DRLRARKATQEELQTVHTEAHAMLFGSNQCQLSRPKLENTLSASFVRLSCGGLGVDLDTTWNEHH 948
            |.|.........||      .|::||:        ..|..:...|:.:..|..|  ...:::|..
 Frog   341 DFLETPFIAFVRLQ------QAVMFGA--------LTEVPVPTRFLFILLGPKG--KAKSYHEIG 389

  Fly   949 TATAARMAAGCVIDLALKTA-KGDLRNGF------AVVRPPGHHAEANLAMGFCFFNSIAIAAKL 1006
            .:.|..|:.....|:|.|.. :.||..|.      .:|.|||....|
 Frog   390 RSIATLMSDEVFHDIAYKAKDRQDLIAGIDEFLDEVIVLPPGEWDPA------------------ 436

  Fly  1007 LRQRMP------EVRRILIVDWDVHHGNGTQQAFYQSPDILYLSIHRHDDGNFFPGTGGPTEC 1063
            :|...|      :.|:.:....:....||         |.|      ||:|:   |.||..:|
 Frog   437 IRIEPPKSIPSSDKRKNMYAGGENVQMNG---------DTL------HDEGH---GGGGHGDC 481

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HDAC4	NP_001259507.1	iSH2_PI3K_IA_R	43..>87	CDD:304922
		HDAC_classIIa	837..1211	CDD:212544	50/249 (20%)
slc4a4	XP_004919190.2	Band_3_cyto	111..1052	CDD:421404	86/438 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0123
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900