Protein Alignment HDAC4 and hdac5

DIOPT Version :9

• Sequence 1: NP_001259507.1
• Gene: HDAC4 / 32278
• FlyBaseID: FBgn0041210
• Length: 1269
• Species: Drosophila melanogaster
• Sequence 2: XP_002935586.2
• Gene: hdac5 / 100487783
• XenbaseID: XB-GENE-488749
• Length: 1060
• Species: Xenopus tropicalis
• Alignment Length: 1257
• Identity: 435/1257 - (34%)
• Similarity: 601/1257 - (47%)
• Gaps: 330/1257 - (26%)

  Fly    43 IDQQIMELKKSQELQKQRLINSFQEQSKQMELEHKLQLEHKYQKQPTNKRFSLELIVIIQFAVNS 107
            :.||::.||:.|:||||.|...||:|.:.:..:|::||:
 Frog    98 LQQQLLLLKQQQQLQKQLLFAEFQKQHENLTRQHEVQLQ-------------------------- 136

  Fly   108 HGAFQELRNESMVTAAAAAVAQEQHRQQLHQQQQQHQQQQQQQQHQQQQQQQQARGRDGMKLKQN 172
                :.|:.:..:.||        .|||..:||::.::|:|::..:|:.:||....|:..|.|:
 Frog   137 ----KHLKQQQEIMAA--------KRQQELEQQRKRERQRQEEAEKQRLEQQLLILRNKEKSKE- 188

  Fly   173 CSANASPEVKQILNCFILSRKSQAAASNGTTTTSPYRNRGVVKSSSGESLPAGTVTSAHP--YKI 235
             ||.||.|||..|..|:||:..:...:...:.....:..|...:|...|.|..:.:.|.|  ||:
 Frog   189 -SAIASTEVKLKLQEFLLSKSKEVPGNVNHSILQHPKCWGTHHTSLDHSSPPQSGSPATPPSYKV 252

  Fly   236 PQPPPSLLKY---ESDFPLRKTASEPNL-LKIRLKQSVIERKARIGGPAGARRHERLLQAAQRRQ 296
                 |||..   ..||||||||||||| ::.||||.|.||::   .|...|:...::.|.::|.
 Frog   253 -----SLLATCDGRDDFPLRKTASEPNLKVRSRLKQKVAERRS---SPLLRRKDGTVISAFKKRA 309

  Fly   297 QKNSVLTNCNSTPDSGPNSPPS--AAALAVGVVGSRGSPTSAPIQEENEEGSQYQPGQR-----S 354
            .:..|.:.|||.|.|||:||.|  :|....|:.||  .|..|         |:..|.||     .
 Frog   310 IEIQVSSVCNSAPGSGPSSPNSSNSAICENGLTGS--VPNIA---------SEMLPQQRVLALEG 363

  Fly   355 SINDLPLFSSPSLPNISLGRPHLPNSAQAHAQVNAQVAAQAQAQAQAQAQAHAMFAALAAAQGGC 419
            :...|.|::|||||||.|        ..:.:.:..|.:.|..|:.|:.
 Frog   364 AGGPLGLYTSPSLPNICL--------QGSTSSLTGQFSPQEGAERQSL----------------- 403

  Fly   420 GQPGYYNPLGMAFVGRQPAPLAMIPATGIAPQQPSPVVRSASATSTSSSQASLVGDVAPPQAHAA 484
             :||  .|    |:...|.|                 .......||.::.:.|...:...||...
 Frog   404 -RPG--GP----FINTSPLP-----------------ALDGGEISTLTAPSLLQHVLLLEQARQQ 444

  Fly   485 STILPSSSSYMQQLGSVAGSGVNLHAAAVAAAAAAAAAAGSLPPTNSHGHGHGSHAHPHPHAHGH 549
            |.::.                |.||..  :........:|||
 Frog   445 SALIT----------------VPLHGQ--SPLVGGDRVSGSL----------------------- 468

  Fly   550 GHGHGHGIYAGHQHNVPITDAQVAQVHLHKQGHRPLGRTQSAPLPLGHPMLTGAVQLNVVQTHY- 613
                 ..:..|.:                   ||||.||||:|||.....|.   ||.:...||
 Frog   469 -----RSVTKGTR-------------------HRPLSRTQSSPLPQSPQALQ---QLVLQHQHYL 506

  Fly   614 ------ENSEAERQAYEHQVVNQKVRQTVLTRSGAAAAAAAAAGVSVVREAQLKEEDDDSAAEVM 672
                  :.|||.||...|    .:..:..||.........|...:....|::..:|:|....:..
 Frog   507 DQQHLNKASEAIRQPPTH----PEETEEELTEQDGGERCRAIFTLDGGTESEETQEEDGGEEDDE 567

  Fly   673 DLTDKKKPPKTVLTSTIATSTSQNLPEALAAAAAAAAYRAPHNASSNSASATKSGIKLRDQEYLQ 737
            |..|.:       |:.:..:..:..|:||.....:    .||.|
 Frog   568 DREDSR-------TNGVEHALKKLFPDALPLYQGS----LPHTA--------------------- 600

  Fly   738 QQREQLLLLQQEEELAKSLMRPLSRTLSSPLVPLGPHGLSQIPDTGQQPAPIATSSSADHIPPVN 802
                                  ||||.|||..||.
 Frog   601 ----------------------LSRTQSSPAAPLS------------------------------ 613

  Fly   803 LSLPHRQHRQLMSTLYASQLRNHQPSASGSPPHKV--TTGLAYDPLMLKHSCICGDNAQHPEHSG 865
                                     :.|..|.|:|  ||||.||.|||||.|.|||...||||:|
 Frog   614 -------------------------TCSLEPHHRVISTTGLVYDTLMLKHQCTCGDTNNHPEHAG 653

  Fly   866 RLQSVWARLNETDLVKRCDRLRARKATQEELQTVHTEAHAMLFGSNQCQLSRPKLEN-----TLS 925
            |:||||:||.||.|:.:|.|:|.||||.:|:||||||.|.:|:|::  ..||.|||:     |||
 Frog   654 RIQSVWSRLQETGLLGKCQRVRGRKATLDEIQTVHTEHHTLLYGTS--PQSRHKLESKNILGTLS 716

  Fly   926 AS-FVRLSCGGLGVDLDTTWNEHHTATAARMAAGCVIDLALKTAKGDLRNGFAVVRPPGHHAEAN 989
            .. :..|.|||:|||.||.|||.|:..|.|.|.|.:|:|..|.|.|:|:|||||:||||||||.:
 Frog   717 QKLYAVLPCGGIGVDSDTVWNELHSPPAVRTAVGSLIELVYKVAAGELKNGFAVIRPPGHHAEES 781

  Fly   990 LAMGFCFFNSIAIAAKLLRQRMPEVRRILIVDWDVHHGNGTQQAFYQSPDILYLSIHRHDDGNFF 1054
            :|||||||||:|||||||||:| .|.||||||||:|||||||||||..|:|||:|:||:||||||
 Frog   782 VAMGFCFFNSVAIAAKLLRQKM-NVGRILIVDWDIHHGNGTQQAFYNDPNILYISLHRYDDGNFF 845

  Fly  1055 PGTGGPTECGSGAGLGFNVNISWSGALNPPLGDAEYIAAFRTVVMPIARSFNPDIVLVSSGFDAA 1119
            ||:|...|.|:|.|.||||||:|:|.::||:|||||:||||.||||:|:.|:||.||||:||||.
 Frog   846 PGSGSSDEVGAGHGTGFNVNIAWTGGVDPPVGDAEYLAAFRMVVMPVAKEFSPDFVLVSAGFDAV 910

  Fly  1120 TGHPAPLGGYHVSPACFGFMTRELLQLANGKVVLALEGGYDLAAICDSAQECVRALLGDPAAPIA 1184
            .||.:|||||.|:..|||.:|::|:.||.|:||||||||:||.||||:::.||.||||....|..
 Frog   911 EGHQSPLGGYSVTAKCFGHLTKQLMTLAGGQVVLALEGGHDLTAICDASEACVSALLGMEPTPFD 975

  Fly  1185 KAELERPPCQNAINTLQKTIAIQQTHWPCVRMLEHTVGLSALETLKVEHDESETINAMAGLSMQS 1249
            .:.|::.|..|||.||::.|.|...||.|::  ..|:|.|.||..:||.:|:|.::|:|.||:.:
 Frog   976 NSVLQQRPSDNAIATLERVINIHGKHWSCLK--SSTLGFSILEAQRVELEEAEAVSALASLSVDT 1038

  Fly  1250 MHRTLSRDDS-----EEPMDQD 1266
               .....||     ||||:.:
 Frog  1039 ---DQCNSDSNPRPLEEPMEDE 1057

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HDAC4	NP_001259507.1	iSH2_PI3K_IA_R	43..>87	CDD:304922	16/43 (37%)
		HDAC_classIIa	837..1211	CDD:212544	232/381 (61%)
hdac5	XP_002935586.2	ClassIIa_HDAC5_Gln-rich-N	90..177	CDD:197400	28/116 (24%)
		HDAC5	623..1040	CDD:212531	248/424 (58%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	457	1.000	Domainoid score	I489
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	694	1.000	Inparanoid score	I667
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D119187at33208
OrthoFinder	1	1.000	-	-		FOG0001001
OrthoInspector	1	1.000	-	-		otm49211
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2991
SonicParanoid	1	1.000	-	-		X933
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.090