DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HDAC4 and hdac6

DIOPT Version :9

Sequence 1:	NP_001259507.1	Gene:	HDAC4 / 32278	FlyBaseID:	FBgn0041210	Length:	1269	Species:	Drosophila melanogaster
Sequence 2:	XP_031746852.1	Gene:	hdac6 / 100379853	XenbaseID:	XB-GENE-5873935	Length:	1056	Species:	Xenopus tropicalis

Alignment Length:	485	Identity:	160/485 - (32%)
Similarity:	246/485 - (50%)	Gaps:	68/485 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   800 PVNLSLPHR-----QHRQLMSTLY---ASQLRNHQPSAS-------GSPPHKVT-----TGLAYD 844
            |::...|.|     |..|.:..|.   |.::|..:|..|       |..|:|..     |||.||
Frog    31 PLSRKAPRRKGASPQGSQSLRKLKKRGAHRMRRTRPRRSCVTTRGTGGEPYKARQAVQGTGLVYD 95

  Fly   845 PLMLKHSCICGDNAQHPEHSGRLQSVWARLNETDLVKRCDRLRARKATQEELQTVHTEAHAMLFG 909
            ..|.:..| ..:|  .||...|:.:|..::.|..|.:||..::||:|::||:..:|:..:..|.|
Frog    96 EQMAQTCCXWDEN--FPECPARIWAVRDKMAEYGLAERCVAVQAREASEEEISLIHSPQYVALMG 158

  Fly   910 SNQCQLSRPKLENTLSASFVRLSCGGLGVDLDTTWNEHHTATAARMAAGCVIDLALKTAKGDLRN 974
            |.| .::..:|: .||..:            |:.:....:.|.|.:|.|.|:.|..|..:.::||
Frog   159 STQ-NMNVEELQ-ALSDRY------------DSVYLHPTSFTCASLAVGSVLQLVDKVLRREIRN 209

  Fly   975 GFAVVRPPGHHAEANLAMGFCFFNSIAIAAKLLRQRMPEVRRILIVDWDVHHGNGTQQAFYQSPD 1039
            |.||||||||||..:...|:|.||.:||||: ..||....:|:||||||||||.|||..|...|.
Frog   210 GLAVVRPPGHHAHVDQMNGYCMFNQLAIAAR-YAQRTYGAKRVLIVDWDVHHGQGTQFLFENDPS 273

  Fly  1040 ILYLSIHRHDDGNFFP--GTGGPTECGSGAGLGFNVNISWSGALNPPLGDAEYIAAFRTVVMPIA 1102
            :||.|:||:::|.|:|  .....:..|...|..||||::|:   ...:.||:||..|..:::|||
Frog   274 VLYFSVHRYENGGFWPHLRESASSAVGKERGERFNVNVAWN---KTRMSDADYIHVFLNILLPIA 335

  Fly  1103 RSFNPDIVLVSSGFDAATGHPAPLGGYHVSPACFGFMTRELLQLANGKVVLALEGGYDLAAICDS 1167
            ..|.|.:|||::|||:..|.|.  |....:|.||..:|..|:.||.|:::|:|||||:..::.:.
Frog   336 YEFQPHLVLVAAGFDSVVGDPK--GEMSATPGCFSHLTHLLMSLAQGRLILSLEGGYNQRSLAEG 398

  Fly  1168 AQECVRALLGDPAAPIAKAELERPPCQNAINTLQKTIAIQQTHWPCVRMLEHTVGLSALETLKVE 1232
            ...|::||||||.   .|..|...|||:|::::..|::.....|               :.|:..
Frog   399 VCACLKALLGDPC---PKLPLPSAPCQSALDSISDTLSAHCRLW---------------KVLQDY 445

  Fly  1233 HDESETINAMAGLSMQSMHRTLSRDDSEEP 1262
            ..|.|.|:.......|      ..|.::||
Frog   446 ESEGEAIDEPQSAEEQ------PPDGADEP 469

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HDAC4	NP_001259507.1	iSH2_PI3K_IA_R	43..>87	CDD:304922
HDAC4	NP_001259507.1	HDAC_classIIa	837..1211	CDD:212544	138/380 (36%)
hdac6	XP_031746852.1	Arginase_HDAC	103..439	CDD:418394	132/360 (37%)
		Arginase_HDAC	495..848	CDD:418394
		zf-UBP	978..1033	CDD:396634
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1484694at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.010