Protein Alignment HDAC4 and hdac7

DIOPT Version :9

• Sequence 1: NP_001259507.1
• Gene: HDAC4 / 32278
• FlyBaseID: FBgn0041210
• Length: 1269
• Species: Drosophila melanogaster
• Sequence 2: XP_002935701.3
• Gene: hdac7 / 100158627
• XenbaseID: XB-GENE-488662
• Length: 977
• Species: Xenopus tropicalis
• Alignment Length: 1188
• Identity: 401/1188 - (33%)
• Similarity: 545/1188 - (45%)
• Gaps: 342/1188 - (28%)

  Fly   130 EQHRQQLHQQQQQHQQQQQQQQHQ----------QQQQQQQARGRDGMKLKQNCSANASPEVKQI 184
            :|.:.||:....|||..:...:.:          |:...:|...:|    |...||.|||.|||.
 Frog    78 KQTQPQLYSSLSQHQPVEHPLRREAPCRNAELVRQEPSLRQLVNKD----KGKASAMASPAVKQK 138

  Fly   185 LNCFILSRK-SQAAASNGTTTTSPYRNRGVVKSSSGESLPAGTVTSAHPYKIPQPPPSLLKYESD 248
            :...|..:| .|...:|.:|..:|||:..:|:                  |.|.|||.:..:.|.
 Frog   139 IVEMIQKKKFDQNNIANHSTAAAPYRSPEIVE------------------KEPPPPPIMTNFASQ 185

  Fly   249 -----------FPLRKTASEPNL-LKIRLKQSVIERKARIGGPAGARRHERLLQAAQRR---QQK 298
                       ||||:||||||| ...|.|:|...||..:      .|.|....|.:||   .|.
 Frog   186 VSSNSCNPSEHFPLRRTASEPNLKWPCRPKKSGERRKNPL------TRKESAPPAVRRRPPETQD 244

  Fly   299 NSVLTNCNSTPDSGPNSPPSAAALAVGVVGSRGSPTSAP-IQEENEEGSQYQPG---QRSSINDL 359
            :|  .:.:|||.||.:||..:      :....||.:|.| ...|.|...:..||   :...:...
 Frog   245 SS--PSSSSTPVSGCSSPNDS------IPAENGSLSSIPGAASEGEVSRRAVPGVVHRGPYLTTH 301

  Fly   360 PLFSSPSLPNISLGRPHLPNSAQAHAQVNAQVAAQAQAQAQAQAQAHAMFAALAAAQGGCGQPGY 424
            |:|.:|.:.                                                   |..|
 Frog   302 PIFMAPGIE---------------------------------------------------GHDG- 314

  Fly   425 YNPLGMAFVGRQPAPLAMIPATGIAPQQPSPVVRSASATSTSSSQASLVGDVAPPQAHAASTILP 489
            .|||                ||.:     .||:    ....|.:...||.
 Frog   315 TNPL----------------ATRL-----QPVI----ILEQSGAHTPLVA--------------- 339

  Fly   490 SSSSYMQQLGSVAGSGVNLHAAAVAAAAAAAAAAGSLPPTNSHGHGHGSHAHPHPHAHGHGHGHG 554
                 :|.||||
 Frog   340 -----VQGLGSV----------------------------------------------------- 346

  Fly   555 HGIYAGHQHNVPITDAQVAQVHLHKQGHRPLGRTQSAPLPLGHPMLTGAVQLNVVQTHY----EN 615
                            |.|...:....|:||.||:|.|||.....|.   |..:.|..|    |:
 Frog   347 ----------------QFAHAFISPDHHKPLSRTRSEPLPQNPKTLQ---QQLLYQQQYSIFPEH 392

  Fly   616 SEAERQAYEHQVVNQKVRQTVLTRSGAAAAAAAAAGVSVVREAQL-KEEDDDSAAEVMDLTDKKK 679
            .:.:||..:.   :||..:.                   .|.:|: .||.|:|::...|
 Frog   393 MKQQRQLSKR---SQKTSER-------------------PRLSQIPSEEMDESSSPTAD------ 429

  Fly   680 PPKTVLTSTIATSTSQNLPEALAAAAAAAAYRAPHNASSNSASATKSGIKL-------RDQEYLQ 737
                                            .|::...|.|.|....:::       ..|:.:|
 Frog   430 --------------------------------RPNDVGGNPARARSESLRVGQHETLSSSQQAIQ 462

  Fly   738 QQREQLLLLQQEEELAKSLMRPLSRTLSSPLVPLGPHGLSQIPDTGQQPAPIATSSSADHIPPVN 802
            ||::|....||......||.||::|.|....:||.|        .|.:|...|.||      |.:
 Frog   463 QQQQQHSFHQQAYLYESSLHRPVNRPLDVLTIPLMP--------GGHRPLSRAKSS------PAS 513

  Fly   803 LSLPHRQ-HRQLMSTLYASQLRNHQPSASGSPPHKVTTGLAYDPLMLKHSCICGDNAQHPEHSGR 866
            .|||.:: ..:.||.          |....:...:.|||:.||.:||||.|.||||:.||||:||
 Frog   514 ASLPAQEPSAKAMSI----------PMLEQATKPRFTTGIVYDSVMLKHQCTCGDNSNHPEHAGR 568

  Fly   867 LQSVWARLNETDLVKRCDRLRARKATQEELQTVHTEAHAMLFGSNQCQLSRPKLENTLSAS---- 927
            :||:|:||.|..|...|:.:|.||||.||||:||||.|.:|:|:|  .|:|.||:|...|.
 Frog   569 IQSIWSRLQERGLRNNCECIRGRKATLEELQSVHTETHVLLYGTN--PLNRLKLDNRKLAGILSQ 631

  Fly   928 --FVRLSCGGLGVDLDTTWNEHHTATAARMAAGCVIDLALKTAKGDLRNGFAVVRPPGHHAEANL 990
              ||.|.|||||||.||.|||.|::.|||.|||.|||||.|.|..:|:||||:||||||||:.:.
 Frog   632 RMFVMLPCGGLGVDSDTIWNELHSSNAARWAAGSVIDLAFKVASRELKNGFALVRPPGHHADPST 696

  Fly   991 AMGFCFFNSIAIAAKLLRQRMPEVRRILIVDWDVHHGNGTQQAFYQSPDILYLSIHRHDDGNFFP 1055
            |||||||||:|||||.|:.|. :||:|||||||||||||||:.||..|::||:|:||||||||||
 Frog   697 AMGFCFFNSVAIAAKQLQLRR-DVRKILIVDWDVHHGNGTQRVFYTDPNVLYISLHRHDDGNFFP 760

  Fly  1056 GTGGPTECGSGAGLGFNVNISWSGALNPPLGDAEYIAAFRTVVMPIARSFNPDIVLVSSGFDAAT 1120
            |:|...|.|:|.|.|||||::|:|.|:||:||.||:.||||||||||..|:||:||||:|||||.
 Frog   761 GSGAADEVGAGNGEGFNVNVAWTGGLDPPMGDVEYLTAFRTVVMPIAHEFSPDVVLVSAGFDAAE 825

  Fly  1121 GHPAPLGGYHVSPACFGFMTRELLQLANGKVVLALEGGYDLAAICDSAQECVRALLGDPAAPIAK 1185
            |||||||||.|:..|||.|||:|:.||.|:||||||||:||.:|||:::.||.||||:...|:.:
 Frog   826 GHPAPLGGYKVTAKCFGHMTRQLMSLAGGRVVLALEGGHDLTSICDASEACVSALLGNELDPLPE 890

  Fly  1186 AELERPPCQNAINTLQKTIAIQQTHWPCVRMLEHTVGLSALETLKVEHDESETINAMAGLSM-QS 1249
            ..|.:.|.|||:.:|:..|.:|..:|..|:.....|..:.||..|.:.||.:|:.|:|.||: :.
 Frog   891 ETLRQRPNQNAVCSLETVIHVQSKYWTSVKQFASKVQYTLLEAQKHDRDEVDTVTALASLSVGRG 955

  Fly  1250 MHRTLSRDDSEEPMDQDE 1267
            ..........||||::||
 Frog   956 SIAVAGNRPQEEPMEEDE 973

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HDAC4	NP_001259507.1	iSH2_PI3K_IA_R	43..>87	CDD:304922
		HDAC_classIIa	837..1211	CDD:212544	232/379 (61%)
hdac7	XP_002935701.3	HDAC7	539..916	CDD:212532	232/379 (61%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	457	1.000	Domainoid score	I489
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	694	1.000	Inparanoid score	I667
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D119187at33208
OrthoFinder	1	1.000	-	-		FOG0001001
OrthoInspector	1	1.000	-	-		otm49211
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X933
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.060