Protein Alignment HDAC4 and hdac7

DIOPT Version :10

• Sequence 1: NP_001259507.1
• Gene: HDAC4 / 32278
• FlyBaseID: FBgn0041210
• Length: 1269
• Species: Drosophila melanogaster
• Sequence 2: XP_002935701.3
• Gene: hdac7 / 100158627
• XenbaseID: XB-GENE-488662
• Length: 977
• Species: Xenopus tropicalis
• Alignment Length: 1193
• Identity: 401/1193 - (33%)
• Similarity: 546/1193 - (45%)
• Gaps: 352/1193 - (29%)

  Fly   130 EQHRQQLHQQQQQHQQQQQQQQHQ----------QQQQQQQARGRDGMKLKQNCSANASPEVKQI 184
            :|.:.||:....|||..:...:.:          |:...:|...:|    |...||.|||.|||.
 Frog    78 KQTQPQLYSSLSQHQPVEHPLRREAPCRNAELVRQEPSLRQLVNKD----KGKASAMASPAVKQK 138

  Fly   185 LNCFILSRK-SQAAASNGTTTTSPYRNRGVVKSSSGESLPAGTVTSAHPYKIPQPPPSLLKYESD 248
            :...|..:| .|...:|.:|..:|||:..:|:                  |.|.|||.:..:.|.
 Frog   139 IVEMIQKKKFDQNNIANHSTAAAPYRSPEIVE------------------KEPPPPPIMTNFASQ 185

  Fly   249 -----------FPLRKTASEPNL-LKIRLKQSVIERKARIGGPAGARRHERLLQAAQRR---QQK 298
                       ||||:||||||| ...|.|:|...||..:      .|.|....|.:||   .|.
 Frog   186 VSSNSCNPSEHFPLRRTASEPNLKWPCRPKKSGERRKNPL------TRKESAPPAVRRRPPETQD 244

  Fly   299 NSVLTNCNSTPDSGPNSPPSAAALAVGVVGSRGSPTSAP-IQEENEEGSQYQPG---QRSSINDL 359
            :|  .:.:|||.||.:||..:      :....||.:|.| ...|.|...:..||   :...:...
 Frog   245 SS--PSSSSTPVSGCSSPNDS------IPAENGSLSSIPGAASEGEVSRRAVPGVVHRGPYLTTH 301

  Fly   360 PLFSSPSLPNISLGRPHLPNSAQAHAQVNAQVAAQAQAQAQAQAQAHAMFAALAAAQGGCGQPGY 424
            |:|.:|.:.                                                   |..|
 Frog   302 PIFMAPGIE---------------------------------------------------GHDG- 314

  Fly   425 YNPLGMAFVGRQPAPLAMIPATGIAPQQPSPVVRSASATSTSSSQASLVGDVAPPQAHAASTILP 489
            .|||                ||.:     .||:                             ||.
 Frog   315 TNPL----------------ATRL-----QPVI-----------------------------ILE 329

  Fly   490 SSSSY-----MQQLGSVAGSGVNLHAAAVAAAAAAAAAAGSLPPTNSHGHGHGSHAHPHPHAHGH 549
            .|.::     :|.||||
 Frog   330 QSGAHTPLVAVQGLGSV------------------------------------------------ 346

  Fly   550 GHGHGHGIYAGHQHNVPITDAQVAQVHLHKQGHRPLGRTQSAPLPLGHPMLTGAVQLNVVQTHY- 613
                                 |.|...:....|:||.||:|.|||.....|.   |..:.|..|
 Frog   347 ---------------------QFAHAFISPDHHKPLSRTRSEPLPQNPKTLQ---QQLLYQQQYS 387

  Fly   614 ---ENSEAERQAYEHQVVNQKVRQTVLTRSGAAAAAAAAAGVSVVREAQL-KEEDDDSAAEVMDL 674
               |:.:.:||..:.   :||..:.                   .|.:|: .||.|:|::...|
 Frog   388 IFPEHMKQQRQLSKR---SQKTSER-------------------PRLSQIPSEEMDESSSPTAD- 429

  Fly   675 TDKKKPPKTVLTSTIATSTSQNLPEALAAAAAAAAYRAPHNASSNSASATKSGIKL-------RD 732
                                                 .|::...|.|.|....:::       ..
 Frog   430 -------------------------------------RPNDVGGNPARARSESLRVGQHETLSSS 457

  Fly   733 QEYLQQQREQLLLLQQEEELAKSLMRPLSRTLSSPLVPLGPHGLSQIPDTGQQPAPIATSSSADH 797
            |:.:|||::|....||......||.||::|.|....:||.|        .|.:|...|.||
 Frog   458 QQAIQQQQQQHSFHQQAYLYESSLHRPVNRPLDVLTIPLMP--------GGHRPLSRAKSS---- 510

  Fly   798 IPPVNLSLPHRQ-HRQLMSTLYASQLRNHQPSASGSPPHKVTTGLAYDPLMLKHSCICGDNAQHP 861
              |.:.|||.:: ..:.||.          |....:...:.|||:.||.:||||.|.||||:.||
 Frog   511 --PASASLPAQEPSAKAMSI----------PMLEQATKPRFTTGIVYDSVMLKHQCTCGDNSNHP 563

  Fly   862 EHSGRLQSVWARLNETDLVKRCDRLRARKATQEELQTVHTEAHAMLFGSNQCQLSRPKLENTLSA 926
            ||:||:||:|:||.|..|...|:.:|.||||.||||:||||.|.:|:|:|  .|:|.||:|...|
 Frog   564 EHAGRIQSIWSRLQERGLRNNCECIRGRKATLEELQSVHTETHVLLYGTN--PLNRLKLDNRKLA 626

  Fly   927 S------FVRLSCGGLGVDLDTTWNEHHTATAARMAAGCVIDLALKTAKGDLRNGFAVVRPPGHH 985
            .      ||.|.|||||||.||.|||.|::.|||.|||.|||||.|.|..:|:||||:|||||||
 Frog   627 GILSQRMFVMLPCGGLGVDSDTIWNELHSSNAARWAAGSVIDLAFKVASRELKNGFALVRPPGHH 691

  Fly   986 AEANLAMGFCFFNSIAIAAKLLRQRMPEVRRILIVDWDVHHGNGTQQAFYQSPDILYLSIHRHDD 1050
            |:.:.|||||||||:|||||.|:.|. :||:|||||||||||||||:.||..|::||:|:|||||
 Frog   692 ADPSTAMGFCFFNSVAIAAKQLQLRR-DVRKILIVDWDVHHGNGTQRVFYTDPNVLYISLHRHDD 755

  Fly  1051 GNFFPGTGGPTECGSGAGLGFNVNISWSGALNPPLGDAEYIAAFRTVVMPIARSFNPDIVLVSSG 1115
            ||||||:|...|.|:|.|.|||||::|:|.|:||:||.||:.||||||||||..|:||:||||:|
 Frog   756 GNFFPGSGAADEVGAGNGEGFNVNVAWTGGLDPPMGDVEYLTAFRTVVMPIAHEFSPDVVLVSAG 820

  Fly  1116 FDAATGHPAPLGGYHVSPACFGFMTRELLQLANGKVVLALEGGYDLAAICDSAQECVRALLGDPA 1180
            ||||.|||||||||.|:..|||.|||:|:.||.|:||||||||:||.:|||:::.||.||||:..
 Frog   821 FDAAEGHPAPLGGYKVTAKCFGHMTRQLMSLAGGRVVLALEGGHDLTSICDASEACVSALLGNEL 885

  Fly  1181 APIAKAELERPPCQNAINTLQKTIAIQQTHWPCVRMLEHTVGLSALETLKVEHDESETINAMAGL 1245
            .|:.:..|.:.|.|||:.:|:..|.:|..:|..|:.....|..:.||..|.:.||.:|:.|:|.|
 Frog   886 DPLPEETLRQRPNQNAVCSLETVIHVQSKYWTSVKQFASKVQYTLLEAQKHDRDEVDTVTALASL 950

  Fly  1246 SM-QSMHRTLSRDDSEEPMDQDE 1267
            |: :...........||||::||
 Frog   951 SVGRGSIAVAGNRPQEEPMEEDE 973

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HDAC4	NP_001259507.1	ClassIIa_HDAC_Gln-rich-N	43..>87	CDD:421006
		HDAC_classIIa	837..1211	CDD:212544	232/379 (61%)
hdac7	XP_002935701.3	HDAC7	539..916	CDD:212532	232/379 (61%)