DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HDAC4 and HDAC6

DIOPT Version :9

Sequence 1:	NP_001259507.1	Gene:	HDAC4 / 32278	FlyBaseID:	FBgn0041210	Length:	1269	Species:	Drosophila melanogaster
Sequence 2:	NP_001308154.1	Gene:	HDAC6 / 10013	HGNCID:	14064	Length:	1229	Species:	Homo sapiens

Alignment Length:	544	Identity:	189/544 - (34%)
Similarity:	273/544 - (50%)	Gaps:	55/544 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   697 LPEAL----AAAAAAAAYRAPHNASSNSASATKSGIKLRDQEYLQQQREQLLLLQQEEELAKSL- 756
            ||.||    .....||.:.|.........:||.:|.         .|...||:.....:|..||
Human   342 LPVALEFQPQLVLVAAGFDALQGDPKGEMAATPAGF---------AQLTHLLMGLAGGKLILSLE 397

  Fly   757 ----MRPLSRTLSSPLVPL--GPHGLSQIPDTGQQPAPIATSSSADHIPPVNLSLPHRQHRQLMS 815
                :|.|:..:|:.|..|  .|..:.:.|....:.|..:.|.:.:.:.|....|..........
Human   398 GGYNLRALAEGVSASLHTLLGDPCPMLESPGAPCRSAQASVSCALEALEPFWEVLVRSTETVERD 462

  Fly   816 TLYASQLRNHQPSASGSPP---------HKVTTGLAYDPLMLKHSCICGDNAQHPEHSGRLQSVW 871
            .:....:...:......||         .:..|||.||..|:.| |...| :.|||...|:..:.
Human   463 NMEEDNVEESEEEGPWEPPVLPILTWPVLQSRTGLVYDQNMMNH-CNLWD-SHHPEVPQRILRIM 525

  Fly   872 ARLNETDLVKRCDRLRARKATQEELQTVHTEAHAMLFGSNQCQLSRPKLENTLSASFVRLSCGGL 936
            .||.|..|..||..|..|.||:.||.|.|:..:.....:.:...:| :|....|
Human   526 CRLEELGLAGRCLTLTPRPATEAELLTCHSAEYVGHLRATEKMKTR-ELHRESS----------- 578

  Fly   937 GVDLDTTWNEHHTATAARMAAGCVIDLALKTAKGDLRNGFAVVRPPGHHAEANLAMGFCFFNSIA 1001
              :.|:.:....|...|::|.|....|......|::.||.|||||||||||.:.|.|||||||:|
Human   579 --NFDSIYICPSTFACAQLATGAACRLVEAVLSGEVLNGAAVVRPPGHHAEQDAACGFCFFNSVA 641

  Fly  1002 IAAKLLRQRMPEVRRILIVDWDVHHGNGTQQAFYQSPDILYLSIHRHDDGNFFP--GTGGPTECG 1064
            :||:..:.......||||||||||||||||..|...|.:||:|:||:|.|.|||  ..|..::.|
Human   642 VAARHAQTISGHALRILIVDWDVHHGNGTQHMFEDDPSVLYVSLHRYDHGTFFPMGDEGASSQIG 706

  Fly  1065 SGAGLGFNVNISWSGALNPPLGDAEYIAAFRTVVMPIARSFNPDIVLVSSGFDAATGHPAPLGGY 1129
            ..||.||.||::|:|   |.:|||:|:||:..:|:|||..|||::||||:|||||.|.  ||||.
Human   707 RAAGTGFTVNVAWNG---PRMGDADYLAAWHRLVLPIAYEFNPELVLVSAGFDAARGD--PLGGC 766

  Fly  1130 HVSPACFGFMTRELLQLANGKVVLALEGGYDLAAICDSAQECVRALLGDPAAPIAKAELERPPCQ 1194
            .|||..:..:|..|:.||:|:::|.|||||:|.:|.:|...|.|:|||||...:.   |.|||..
Human   767 QVSPEGYAHLTHLLMGLASGRIILILEGGYNLTSISESMAACTRSLLGDPPPLLT---LPRPPLS 828

  Fly  1195 NAINTLQKTIAIQQTHWPCVRMLE 1218
            .|:.::.:||.:.:.:|..:|:::
Human   829 GALASITETIQVHRRYWRSLRVMK 852

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HDAC4	NP_001259507.1	iSH2_PI3K_IA_R	43..>87	CDD:304922
HDAC4	NP_001259507.1	HDAC_classIIa	837..1211	CDD:212544	158/375 (42%)
HDAC6	NP_001308154.1	HDAC6-dom1	113..449	CDD:212545	26/115 (23%)
		HDAC6-dom2	499..849	CDD:212527	156/373 (42%)
		zf-UBP	1147..1209	CDD:280334
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0123
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1484694at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100220
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2991
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.750