DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mew and ITGA10

DIOPT Version :9

Sequence 1:	NP_001285196.1	Gene:	mew / 32275	FlyBaseID:	FBgn0004456	Length:	1243	Species:	Drosophila melanogaster
Sequence 2:	XP_016858111.1	Gene:	ITGA10 / 8515	HGNCID:	6135	Length:	1181	Species:	Homo sapiens

Alignment Length:	1002	Identity:	249/1002 - (24%)
Similarity:	391/1002 - (39%)	Gaps:	275/1002 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   202 YGL--CQAGTSAALLDDDTMVLGSPGPYTWRGSI-WVTQVGGE-------YLQRDKTTYYSDHSD 256
            :||  .|.|.|...|.|. ::.|..|.|.|.||: |:.  ||.       .|:.:......:|:
Human   382 FGLEMSQIGFSTHRLKDG-ILFGMVGAYDWGGSVLWLE--GGHRLFPPRMALEDEFPPALQNHA- 442

  Fly   257 LNSPVDKYSYLGMSVT-----GGRFFGHMSYAAGAPRSEGHGQVVIFDKSTDNPIPVHSILDGEQ 316
                    :|||.||:     |||    ..:.:||||....|:|:.|....|..:.|...|.|||
Human   443 --------AYLGYSVSSMLLRGGR----RLFLSGAPRFRHRGKVIAFQLKKDGAVRVAQSLQGEQ 495

  Fly   317 FGSSFGYELATADINGDHRPD-LIVAAPLYF--TKTEGGAVYVY-QNIQDTLPMKYTLKLTGPLE 377
            .||.||.||...|.:.|...| |:||||::.  ...|.|.|||| ...|..|.::.||:...|.:
Human   496 IGSYFGSELCPLDTDRDGTTDVLLVAAPMFLGPQNKETGRVYVYLVGQQSLLTLQGTLQPEPPQD 560

  Fly   378 SRFGLALANIGDLNKDNCEDLAVGAPYEG--NGVVYIYLGSSQGLNSKPAQKIQASELGGTIPNG 440
            :|||.|:..:.|||:|...|:|||||.|.  .|.:|:|.|:..|:...|||:|.|:    ::|:.
Human   561 ARFGFAMGALPDLNQDGFADVAVGAPLEDGHQGALYLYHGTQSGVRPHPAQRIAAA----SMPHA 621

  Fly   441 QPIRTFGISISGNTDLDDNSYPDVVIGAFNSSAAVILLARPII----SIQTSVQRKELHNMDPNT 501
              :..||.|:.|..|||.:...||.:||  ..||::|.:|||:    |::.:.|...:...|...
Human   622 --LSYFGRSVDGRLDLDGDDLVDVAVGA--QGAAILLSSRPIVHLTPSLEVTPQAISVVQRDCRR 682

  Fly   502 PGCLDDPASNLTCFTFRACCSIEPYDEKNKELRLAYSVEAET---FDHLKKFSRVF--------- 554
            .|      ....|.|...|                :.|.:.|   :||  :|...|
Human   683 RG------QEAVCLTAALC----------------FQVTSRTPGRWDH--QFYMRFTASLDEWTA 723

  Fly   555 ----FFDRENKRTNVLSRVVRVHTNGRTECQAVTGYIKANTRDIQTPVRFRLKYSLVEPPLADSA 615
                .||...:|.:  .|.:|:.. |...|:.:..:: .:|.|...||...:.::|      |:.
Human   724 GARAAFDGSGQRLS--PRRLRLSV-GNVTCEQLHFHV-LDTSDYLRPVALTVTFAL------DNT 778

  Fly   616 LVRLNPILDQTQAHVDFEGT---------FQKDCGDDDLCESNLIIRVEPNITESSGNEYTLILD 671
             .:..|:|:        ||:         |.||||.|:.|.::|:::|..:|..|....:.:...
Human   779 -TKPGPVLN--------EGSPTSIQKLVPFSKDCGPDNECVTDLVLQVNMDIRGSRKAPFVVRGG 834

  Fly   672 ETELEVRINVSNLADSAYEAQLFI-----AHQAGVSYVATKKPTNATCNSYNTTLVACSLGNPML 731
            ..::.|...:.|..::||...|.:     .|.|.:: ...:.|....|.:.:.....||:|:|:.
Human   835 RRKVLVSTTLENRKENAYNTSLSLIFSRNLHLASLT-PQRESPIKVECAAPSAHARLCSVGHPVF 898

  Fly   732 RDTTTFVTIRFQPKGLEPSEKIMLFHIFANTTSKLVGPERPERDLRVNVVR-RAKLNFRGWAIPE 795
            : |...||...:   .|.|...:|..:|...|:.....|| ...|:.|..: .|.:.:.    |.
Human   899 Q-TGAKVTFLLE---FEFSCSSLLSQVFVKLTASSDSLER-NGTLQDNTAQTSAYIQYE----PH 954

  Fly   796 QSFYSGSSVANSVANTAATDIEGHGP-----MGMDDVGSQVHHMFTIFNEGPSTAPKVQMVIHWP 855
            ..|.|.|::.....:...|...|.||     :.:.::|..|.....|....|:.|
Human   955 LLFSSESTLHRYEVHPYGTLPVGPGPEFKTTLRVQNLGCYVVSGLIISALLPAVA---------- 1009

  Fly   856 YSLYSDPQSGRPVQYLLYLEQVPTVEVSQGECHVAKEYVNPLNLASGSRENPAYLSAPAQMRMFP 920
                   ..|   .|.|.|.||.|                  |.||...:|   |:.|....:.|
Human  1010 -------HGG---NYFLSLSQVIT------------------NNASCIVQN---LTEPPGPPVHP 1043

  Fly   921 SQSRHSFNKSLIHSQRSYYSSSHRDDHSDDTQSNRNRVRRSFLERVTR----LERLMYDPESSNA 981
            .:.:|: |:.                :..:||....|.....|.:.|.    |.||::: |....
Human  1044 EELQHT-NRL----------------NGSNTQCQVVRCHLGQLAKGTEVSVGLLRLVHN-EFFRR 1090

  Fly   982 ANGKKQDIV---ELDCNKGATNCVRIECDILNMPALSEAQVVVKARLWNSTLVSEYPRVERVRIF 1043
            |..|...:|   ||...:|:         :|.:         .:|..|:.:|
Human  1091 AKFKSLTVVSTFELGTEEGS---------VLQL---------TEASRWSESL------------- 1124

  Fly  1044 STATAQIPESYGVEVMDHNNIEVETRAYPELRNQQRDTSIPWLIIILGIVGGLLLLALVTYVLWK 1108
                        :||:                 |.|...|...|:|..::||||||||:.:.|||
Human  1125 ------------LEVV-----------------QTRPILISLWILIGSVLGGLLLLALLVFCLWK 1160

  Fly  1109 VGFF--KRIRPTDPTLSGNLEKMNEEK 1133
            :|||  |:|..         |:..|||
Human  1161 LGFFAHKKIPE---------EEKREEK 1178

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mew	NP_001285196.1	Int_alpha	48..111	CDD:214549
		Int_alpha	317..368	CDD:214549	22/54 (41%)
		Int_alpha	378..428	CDD:214549	23/51 (45%)
		Int_alpha	446..491	CDD:214549	18/48 (38%)
		Integrin_alpha2	479..1006	CDD:285619	114/573 (20%)
ITGA10	XP_016858111.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141984
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3637
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740