DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mew and Itgae

DIOPT Version :9

Sequence 1:	NP_001285196.1	Gene:	mew / 32275	FlyBaseID:	FBgn0004456	Length:	1243	Species:	Drosophila melanogaster
Sequence 2:	NP_113956.2	Gene:	Itgae / 83577	RGDID:	621644	Length:	1169	Species:	Rattus norvegicus

Alignment Length:	1076	Identity:	252/1076 - (23%)
Similarity:	408/1076 - (37%)	Gaps:	302/1076 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   108 VITDGRRNFDSEILSPPGN--DEIKEDQWMGVTVR-----SNPLQANGSGG--KVIVCAHRYMYI 163
            |:|||      :|...|.|  ..|...:..|| ||     .|..:.|.:..  |:|....:..:.
  Rat   304 VLTDG------DIFRDPLNLTTVISSSKMQGV-VRFAIGVGNAFENNNTYRELKLIASDPKAAHT 361

  Fly   164 VRENRYG--QGLCYLLTNDLQFEEVH-EPCKGRPVQRQHEDYGLCQAGTSAALLDDDTMVLGSPG 225
            .:...|.  .|    |.:.||...:| |...|..:|     |.|.|.|.||.:||...::||:.|
  Rat   362 FKVTNYSALDG----LLSKLQQRIIHMEGTVGDTLQ-----YQLAQTGFSAQILDKGQVLLGTVG 417

  Fly   226 PYTWRGS--IWVTQVG-GEYLQRDKTTYYSDHSDLNSPVDKYSYLGMSVTGGRFFGHMSYAAGAP 287
            .:.|.|.  ::.||.| |.:|.:      :...|..:.  :|||||.||........:||.||||
  Rat   418 AFNWSGGALLYNTQNGRGRFLNQ------TAKEDFRAA--QYSYLGYSVAALHKAHGVSYVAGAP 474

  Fly   288 RSEGHGQVVIFDKSTDNPIPVHSILDGEQFGSSFGYELATADINGDHRPD-LIVAAPLYFTKTEG 351
            |.:..|.|....|. |........::|||.||.||..|...|||.|...| |:||||.|..:.|.
  Rat   475 RHKLRGAVFELQKE-DGEETFMRRIEGEQMGSYFGSVLCPVDINMDGITDFLLVAAPFYHIRGEE 538

  Fly   352 GAVYVYQNIQDTLP--MKYTLK-LTGPLESRFGLALANIGDLNKDNCEDLAVGAPYEGNGV---- 409
            |.||||:..:...|  :.|||. ..|...||||.|:|.:||:|:|...|:|:|||.||.|.
  Rat   539 GRVYVYRVHEQDAPFSLVYTLSGYPGLTSSRFGFAMAAVGDINQDKFTDVAIGAPLEGFGAGDGA 603

  Fly   410 ----VYIYLGSSQGLNSKPAQKIQASE--LGGTIPNGQPIRTFGISISGNTDLDDNSYPDVVIGA 468
                ||||.|.|.||::.|:|:|:||.  ||        :..||:|:||..|...:...|:.:|
  Rat   604 SYGSVYIYNGHSGGLHASPSQQIRASSVALG--------LYYFGMSVSGGLDFSGDDLADITVG- 659

  Fly   469 FNSSAAVILLARPIISIQTSVQRKELHNMDPNT-PGCLDDPASNLTCFTFRACCSIEPYDEKNKE 532
             :...||:|.:||::.:..|:      ...|:. |....|......|  |:...|..|.:...:.
  Rat   660 -SQDVAVVLRSRPVVDLTVSM------TFTPDALPMAFKDKMDVELC--FKVDSSAVPSEPGLRG 715

  Fly   533 LRLAYSVEAETFDHLKKFSRVFFFDRENKRTNVLSRVVRVHTNGRTECQAVTGYIKANTR----D 593
            :.|.::|:.   |..|:..|:...||...::.::.     .:.|.:.|:.. |.|.....    |
  Rat   716 MSLNFTVDV---DVTKQKQRLQCADRSCCQSCLMK-----WSGGSSLCEHF-GLISTEEELCEDD 771

  Fly   594 IQTPVRFRLKYSLVEPPLADSALVRLNPILDQ-TQAHVDFEGTFQKDCGDDDLCESNLIIRVEPN 657
            ..:.:..::.|   |...::......|||||. .:....|:..::|||.:...|.:      |..
  Rat   772 CFSNITIKVSY---EFQTSEERRNHPNPILDHYKEPSAIFQLPYEKDCKNKVFCIA------EIQ 827

  Fly   658 ITESSGNEYTLILDETELEVRINVSNLADSAYEAQLFIAHQAGVSYVATKKPTNATCNSYNTTLV 722
            :|.:...:..::....|:.:.|:::|..:.:|...:.:.:...:.:...:||.:......:...|
  Rat   828 LTTAISQQDLVVGITKEVTMNISLTNSGEDSYMTNMALNYPRNLQFKKIQKPLSPDIQCDDPKPV 892

  Fly   723 A------CSLGNPMLRDTTTFVTIRFQPKGLEPSEKIMLFHIFANTTSKLVGPERPERDLRVNVV 781
            |      |.:|:|:|:.::..|::.:|   ||.|       ||.|.|:          |:.|
  Rat   893 ASVLVMNCKIGHPILKRSSVNVSVTWQ---LEES-------IFPNRTA----------DITV--- 934

  Fly   782 RRAKLNFRGWAIPEQSFYSGSSVANSVANTAATDIEGHGPMGMDDVGSQVHHMFTIFNEGPSTAP 846
                                 :::||  |..:...|.|        ..|..|.|.
  Rat   935 ---------------------TISNS--NEKSLARETH--------SLQFRHAFI---------- 958

  Fly   847 KVQMVIHWPYSLYSDPQSGRPVQYLLYLEQVPTVEVSQGECHVAKEYVNPLNLASGSRENPAYLS 911
                                                                         |.||
  Rat   959 -------------------------------------------------------------AVLS 962

  Fly   912 APAQMRMFPSQSRHS-----FNKSLIHSQRSY---------YSSSHRD-------------DHSD 949
            .|:.|.|..|||...     ||   :|.:..:         ...:.||             .|::
  Rat   963 RPSVMYMNTSQSSSDHKEFFFN---VHGENHFGAVFQLQICVPITLRDLQIIRVKHLTKTQAHTE 1024

  Fly   950 DTQSNRNRVRRSFLERVTRLERLMYDPESSNAANGKKQDI-VELDCNKGATNCVRIECDILNMPA 1013
            .|||.........::.|.....::.      |....|::: |..:.:.|.|.  ::..||..:..
  Rat  1025 CTQSQEPTCGSDPVQNVEEWHSVIC------AITSNKENVTVAAEISMGHTK--QLLRDISELQI 1081

  Fly  1014 LSEAQVVVKARLWNSTLVSEYPRVERVRIFSTATAQIPESYGVEVMDHNNIEVETRAYPELRNQQ 1078
            |.|..       :|.:|..                      |:...:|     .|:.......::
  Rat  1082 LGEIS-------FNKSLYE----------------------GLNAENH-----RTKITVIFLKEE 1112

  Fly  1079 RDTSIPWLIIILGIVGGLLLLALVTYVLWKVGFFKR 1114
            :..|:|  :||...:||||:|.::..:|:|.|||||
  Rat  1113 KPHSLP--LIIGSSIGGLLVLVVIIAILFKCGFFKR 1146

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mew	NP_001285196.1	Int_alpha	48..111	CDD:214549	1/2 (50%)
		Int_alpha	317..368	CDD:214549	23/53 (43%)
		Int_alpha	378..428	CDD:214549	28/57 (49%)
		Int_alpha	446..491	CDD:214549	14/44 (32%)
		Integrin_alpha2	479..1006	CDD:285619	91/566 (16%)
Itgae	NP_113956.2	vWA_integrins_alpha_subunit	196..373	CDD:238746	18/79 (23%)
		Int_alpha	503..559	CDD:214549	24/55 (44%)
		Int_alpha	568..626	CDD:214549	28/57 (49%)
		Integrin_alpha2	669..>952	CDD:285619	64/362 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335706
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3637
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D743479at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.750