DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mew and Itga7

DIOPT Version :9

Sequence 1:	NP_001285196.1	Gene:	mew / 32275	FlyBaseID:	FBgn0004456	Length:	1243	Species:	Drosophila melanogaster
Sequence 2:	NP_110469.1	Gene:	Itga7 / 81008	RGDID:	71022	Length:	1135	Species:	Rattus norvegicus

Alignment Length:	1245	Identity:	364/1245 - (29%)
Similarity:	548/1245 - (44%)	Gaps:	278/1245 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 PNCRLRQNLGILIILQCVLT------CYNFNLEQRLPIVKYGHPHSHFGYSVATHTIGEANGPNK 69
            |.|......||..:|..:|.      ...|||:....|.|.|.|.|.||:|||.|   ....|..
  Rat     5 PRCDFLGLPGICYLLSFLLAGLLLPRASAFNLDVMGAIRKEGEPGSLFGFSVALH---RQLQPRP 66

  Fly    70 TNCVLVGAPLD---QNRQPNTTHSGALWRCPMTQRFDDCEQVITDGRRNFDSEILSPPGNDEIKE 131
            .:.:|||||..   ..:|.|.|  |.|:.||::....||.:|..|...|...         |.||
  Rat    67 QSWLLVGAPQALALPGQQANRT--GGLFACPLSLEETDCYRVDIDRGANVQK---------ESKE 120

  Fly   132 DQWMGVTVRSNPLQANGSGGKVIVCAHRY-----MYIVRENRYGQGLCYLLTNDLQFEEVHEP-- 189
            :||:||:|||     .|:||||:.|||||     :..|.|.|...|.|::|:.||...:..:.
  Rat   121 NQWLGVSVRS-----QGAGGKVVTCAHRYESRQRVDQVLETRDVIGRCFVLSQDLAIRDELDGGE 180

  Fly   190 ---CKGRPVQRQHEDYGLCQAGTSAALL-DDDTMVLGSPGPYTWRGSIWVTQVGGEYLQRDKTTY 250
               |:|||  :.||.:|.||.||:|... |...::.|:||.|.|:|.::||.:...  ..|:..|
  Rat   181 WKFCEGRP--QGHEQFGFCQQGTAATFSPDSHYLIFGAPGTYNWKGLLFVTNIDSS--DPDQLVY 241

  Fly   251 YS-DHSD-LNSPVDKY---SYLGMSVTGGRFF---GHMSYAAGAPRSEGHGQVVIFDKSTDNPIP 307
            .: |.:| |..|....   ||||.|:..|:..   ..:|:.|||||:...|.|||..|.:.:.:.
  Rat   242 KTLDPADRLTGPAGDLTLNSYLGFSIDSGKGLMRSEELSFVAGAPRANHKGAVVILRKDSASRLI 306

  Fly   308 VHSILDGEQFGSSFGYELATADINGDHRPDLIVAAPLYFTKTE--GGAVYVYQN----IQDTLPM 366
            ...:|.||:..|.|||.||..|:|.|...||||.||.:|.:.|  |||||||.|    ..|..|
  Rat   307 PEVVLSGERLTSGFGYSLAVTDLNSDGWADLIVGAPYFFERQEELGGAVYVYMNQGGHWADISP- 370

  Fly   367 KYTLKLTGPLESRFGLALANIGDLNKDNCEDLAVGAPYEGNGVVYIYLGSSQGLNSKPAQKIQAS 431
               |:|.|..:|.||::||.:||||:|...|:|||||::|:|.|:||.|||.|:.:||:|.::..
  Rat   371 ---LRLCGSPDSMFGISLAVLGDLNQDGFPDIAVGAPFDGDGKVFIYHGSSLGVVTKPSQVLEGE 432

  Fly   432 ELGGTIPNGQPIRTFGISISGNTDLDDNSYPDVVIGAFNSSAAVILLARPIISIQTSVQRKELHN 496
            .:|        |::||.|:||..|:|.|.|||:::|:...:|| :..|||::.:...:      .
  Rat   433 AVG--------IKSFGYSLSGGLDVDGNHYPDLLVGSLADTAA-LFRARPVLHVSQEI------F 482

  Fly   497 MDPNT-----PGCLDDPASNLTCFTFRACCS-IEPYDEKNKELRLAYSVEAETFDHLK-KFSRVF 554
            :||..     |.|.|   ..|.|...:.|.| :......:..:.|.|.::.:|...|: :..||.
  Rat   483 IDPRAIDLEQPNCAD---GRLVCVHVKVCFSYVAVPSSYSPIVVLDYVLDGDTDRRLRGQAPRVT 544

  Fly   555 FFDR--ENKRTNVLSRVVRVHTNGRTECQAVTGYIKANTRDIQTPVRFRLKYSLVEPPL----AD 613
            |..|  ::.:......|...|.:.|. |......::.|.:|....:...|.|.|..|.|    .|
  Rat   545 FPGRGPDDLKHQSSGTVSLKHQHDRV-CGDTVFQLQENVKDKLRAIVVTLSYGLQTPRLRRQAPD 608

  Fly   614 SALVRLNPILD-------QTQAHVDFEGTFQKDCGDDDLCESNLIIRVEPNITESSGNEYTLI-- 669
            ..|..:.|||:       :|:.|.     .::.||||.:|:|||.:......:..|..|:..:
  Rat   609 QGLPLVAPILNAHQPSTQRTEIHF-----LKQGCGDDKICQSNLQLAQAQFCSRISDTEFQALPM 668

  Fly   670 -LDETEL---------EVRINVSNL----------ADSAYEAQLFIAHQAGVSYV------ATKK 708
             ||.|.|         .:.:.|:||          .|.|:||||.....|.:.|.      :.:|
  Rat   669 DLDGTALFALSGQPFIGLELTVTNLPSDPARPQADGDDAHEAQLLATLPASLRYSGVRTLDSVEK 733

  Fly   709 PTNATC-NSYNTTLVACSLGNPMLRDTTTFVTIRFQPKGLEPSEKIMLFHIFANTTSKLVGPERP 772
            |   .| ::.|.:.|.|.|||||.|.|.....:.....|:......:...:...|.|
  Rat   734 P---LCLSNENASHVECELGNPMKRGTQVTFYLILSTSGITIETTELKVELLLATIS-------- 787

  Fly   773 ERDL-----RVNVVRRAKLNFRGWAIPEQSFYSGSSVANSVANTAATDIEGHGPMGMD-DVGSQV 831
            |:||     |.:|.....|:..|.|.|:|.|:||.             ::|...|..: ||||:|
  Rat   788 EQDLHPVSVRAHVFIELPLSISGVATPQQLFFSGK-------------VKGESAMRSERDVGSKV 839

  Fly   832 HHMFTIFNEGPS--TAPKVQMVIHWPYSLYSDPQSGRPVQYLLYLEQVPTVEVSQGECHVAKEYV 894
            .:..|:.|:|.|  |.....:.|.||:.:.:.       ::|||..:   ||:..|:....|...
  Rat   840 KYEVTVSNQGQSLNTLGSAFLNIMWPHEIANG-------KWLLYPMR---VELEGGQGPEKKGIC 894

  Fly   895 NPLNLASGSRENPAYLSAPAQMRMFPSQSRHSFNKSLIHSQRSYYSSSHRDDHSDDTQSNRNRVR 959
            :|       |.|..:|..                                        .:|:|.|
  Rat   895 SP-------RPNILHLDV----------------------------------------DSRDRRR 912

  Fly   960 RSFLERVTRLERLMYDPESS--NAANGKKQDIVELDCNKGATNCVRIECDILNMPALSEAQVV-V 1021
            |...:...:......:|.:|  ..::.:|:: |.|||.:|...||...|.:.   :...|.|: |
  Rat   913 RELGQPEPQEPPEKVEPSTSWWPVSSAEKRN-VTLDCAQGTAKCVVFSCPLY---SFDRAAVLHV 973

  Fly  1022 KARLWNSTLVSEYPRVERVRIFSTATAQIPESYGVEVMDHNNIEVETRAYPELRN-QQRDTS--- 1082
            ..||||||.:.||..|:                .:||:...||.|::    .::| ..||.|
  Rat   974 WGRLWNSTFLEEYMSVK----------------SLEVIVRANITVKS----SIKNLLLRDASTVI 1018

  Fly  1083 ---------------IPWLIIILGIVGGLLLLALVTYVLWKVGFFKRIRPTDPT---------LS 1123
                           :||.:|:|.::.|||:|||:..:|||:|||||.:..:.|         |.
  Rat  1019 PVMVYLDPVAVVAEGVPWWVILLAVLAGLLVLALLVLLLWKLGFFKRAKHPEATVPQYHAVKILR 1083

  Fly  1124 GNLEKMNEEK 1133
            .:.::..|||
  Rat  1084 EDRQQFKEEK 1093

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mew	NP_001285196.1	Int_alpha	48..111	CDD:214549	24/65 (37%)
		Int_alpha	317..368	CDD:214549	27/56 (48%)
		Int_alpha	378..428	CDD:214549	28/49 (57%)
		Int_alpha	446..491	CDD:214549	17/44 (39%)
		Integrin_alpha2	479..1006	CDD:285619	132/585 (23%)
Itga7	NP_110469.1	FG-GAP 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	38..103		24/69 (35%)
		Int_alpha	48..109	CDD:214549	24/65 (37%)
		FG-GAP 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	110..165		26/68 (38%)
		FG-GAP 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	185..238		20/56 (36%)
		FG-GAP 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	248..305		20/56 (36%)
		Int_alpha	260..311	CDD:214549	17/50 (34%)
		FG-GAP 5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	306..367		28/60 (47%)
		Int_alpha	318..371	CDD:214549	27/56 (48%)
		FG-GAP 6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	368..423		29/58 (50%)
		Int_alpha	377..429	CDD:214549	28/51 (55%)
		FG-GAP 7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00803	427..486		21/73 (29%)
		Int_alpha	439..>479	CDD:214549	17/40 (43%)
		Integrin_alpha2	471..960	CDD:285619	132/585 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	905..933		5/67 (7%)
		GFFKR motif	1061..1065		3/3 (100%)
		3 X 4 AA repeats of D-X-H-P	1111..1130
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335715
Domainoid	1	1.000	140	1.000	Domainoid score	I4631
eggNOG	1	0.900	-	-		E1_KOG3637
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	379	1.000	Inparanoid score	I1997
OMA	1	1.010	-	-		QHG46425
OrthoDB	1	1.010	-	-		D325432at33208
OrthoFinder	1	1.000	-	-		FOG0001200
OrthoInspector	1	1.000	-	-		otm45706
orthoMCL	1	0.900	-	-		OOG6_102503
Panther	1	1.100	-	-	LDO	PTHR23220
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X929
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.810